ID   TSYL4_HUMAN             Reviewed;         414 AA.
AC   Q9UJ04; B4DYQ2; O94828; Q96GW8;
DT   15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   15-AUG-2003, sequence version 2.
DT   07-APR-2021, entry version 133.
DE   RecName: Full=Testis-specific Y-encoded-like protein 4;
DE            Short=TSPY-like protein 4;
GN   Name=TSPYL4; Synonyms=KIAA0721;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=9872452; DOI=10.1093/dnares/5.5.277;
RA   Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A.,
RA   Kotani H., Nomura N., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. XI. The
RT   complete sequences of 100 new cDNA clones from brain which code for large
RT   proteins in vitro.";
RL   DNA Res. 5:277-286(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA   Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA   Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA   Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA   Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA   French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA   Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA   Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA   Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA   Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA   Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA   Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA   Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA   Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA   Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA   Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA   Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA   Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA   Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA   West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA   Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA   Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA   Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 180-414.
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q9UJ04; Q96JB5: CDK5RAP3; NbExp=6; IntAct=EBI-308511, EBI-718818;
CC       Q9UJ04; Q86XR8-3: CEP57; NbExp=3; IntAct=EBI-308511, EBI-11752486;
CC       Q9UJ04; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-308511, EBI-5916454;
CC       Q9UJ04; P43358: MAGEA4; NbExp=6; IntAct=EBI-308511, EBI-743122;
CC       Q9UJ04; Q8IYV1: NAP1L3; NbExp=3; IntAct=EBI-308511, EBI-10322170;
CC       Q9UJ04; Q8ND90: PNMA1; NbExp=3; IntAct=EBI-308511, EBI-302345;
CC       Q9UJ04; Q9UBB9: TFIP11; NbExp=3; IntAct=EBI-308511, EBI-1105213;
CC       Q9UJ04; P07101-3: TH; NbExp=3; IntAct=EBI-308511, EBI-12001016;
CC       Q9UJ04; O00635: TRIM38; NbExp=6; IntAct=EBI-308511, EBI-2130415;
CC       Q9UJ04; Q8N720: ZNF655; NbExp=3; IntAct=EBI-308511, EBI-625509;
CC       Q9UJ04; Q9UGI0: ZRANB1; NbExp=3; IntAct=EBI-308511, EBI-527853;
CC   -!- SIMILARITY: Belongs to the nucleosome assembly protein (NAP) family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA34441.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AB018264; BAA34441.1; ALT_INIT; mRNA.
DR   EMBL; AK302542; BAG63814.1; -; mRNA.
DR   EMBL; AL050331; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC009116; AAH09116.2; -; mRNA.
DR   CCDS; CCDS5106.1; -.
DR   RefSeq; NP_067680.3; NM_021648.4.
DR   SMR; Q9UJ04; -.
DR   BioGRID; 116871; 23.
DR   IntAct; Q9UJ04; 30.
DR   MINT; Q9UJ04; -.
DR   STRING; 9606.ENSP00000410943; -.
DR   iPTMnet; Q9UJ04; -.
DR   PhosphoSitePlus; Q9UJ04; -.
DR   BioMuta; TSPYL4; -.
DR   DMDM; 34098754; -.
DR   MassIVE; Q9UJ04; -.
DR   MaxQB; Q9UJ04; -.
DR   PaxDb; Q9UJ04; -.
DR   PeptideAtlas; Q9UJ04; -.
DR   PRIDE; Q9UJ04; -.
DR   ProteomicsDB; 84577; -.
DR   Antibodypedia; 32487; 130 antibodies.
DR   DNASU; 23270; -.
DR   Ensembl; ENST00000420283; ENSP00000410943; ENSG00000187189.
DR   GeneID; 23270; -.
DR   KEGG; hsa:23270; -.
DR   UCSC; uc003pwn.4; human.
DR   CTD; 23270; -.
DR   DisGeNET; 23270; -.
DR   GeneCards; TSPYL4; -.
DR   HGNC; HGNC:21559; TSPYL4.
DR   HPA; ENSG00000187189; Tissue enhanced (brain).
DR   neXtProt; NX_Q9UJ04; -.
DR   OpenTargets; ENSG00000187189; -.
DR   PharmGKB; PA134942080; -.
DR   VEuPathDB; HostDB:ENSG00000187189.10; -.
DR   eggNOG; KOG1508; Eukaryota.
DR   GeneTree; ENSGT00940000162991; -.
DR   HOGENOM; CLU_051687_2_0_1; -.
DR   InParanoid; Q9UJ04; -.
DR   OMA; DPQSHIH; -.
DR   OrthoDB; 1191764at2759; -.
DR   PhylomeDB; Q9UJ04; -.
DR   TreeFam; TF313386; -.
DR   PathwayCommons; Q9UJ04; -.
DR   BioGRID-ORCS; 23270; 2 hits in 999 CRISPR screens.
DR   GenomeRNAi; 23270; -.
DR   Pharos; Q9UJ04; Tdark.
DR   PRO; PR:Q9UJ04; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   RNAct; Q9UJ04; protein.
DR   Bgee; ENSG00000187189; Expressed in Brodmann (1909) area 23 and 240 other tissues.
DR   Genevisible; Q9UJ04; HS.
DR   GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR   GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR   GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR   InterPro; IPR037231; NAP-like_sf.
DR   InterPro; IPR002164; NAP_family.
DR   PANTHER; PTHR11875; PTHR11875; 1.
DR   Pfam; PF00956; NAP; 1.
DR   SUPFAM; SSF143113; SSF143113; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..414
FT                   /note="Testis-specific Y-encoded-like protein 4"
FT                   /id="PRO_0000185673"
FT   VARIANT         30
FT                   /note="R -> L (in dbSNP:rs2232470)"
FT                   /id="VAR_050228"
SQ   SEQUENCE   414 AA;  45126 MW;  CD841DA3FEFC445E CRC64;
     MSGLDGGNKL PLAQTGGLAA PDHASGDPDR DQCQGLREET EATQVMANTG GGSLETVAEG
     GASQDPVDCG PALRVPVAGS RGGAATKAGQ EDAPPSTKGL EAASAAEAAD SSQKNGCQLG
     EPRGPAGQKA LEACGAGGLG SQMIPGKKAK EVTTKKRAIS AAVEKEGEAG AAMEEKKVVQ
     KEKKVAGGVK EETRPRAPKI NNCMDSLEAI DQELSNVNAQ ADRAFLQLER KFGRMRRLHM
     QRRSFIIQNI PGFWVTAFRN HPQLSPMISG QDEDMLRYMI NLEVEELKHP RAGCKFKFIF
     QGNPYFRNEG LVKEYERRSS GRVVSLSTPI RWHRGQDPQA HIHRNREGNT IPSFFNWFSD
     HSLLEFDRIA EIIKGELWPN PLQYYLMGEG PRRGIRGPPR QPVESARSFR FQSG
//