ID   RLP24_HUMAN             Reviewed;         163 AA.
AC   Q9UHA3; B2RD72; Q561V8; Q8N6S8; Q96B04; Q96C76; Q96HJ1;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   16-JAN-2019, entry version 153.
DE   RecName: Full=Probable ribosome biogenesis protein RLP24;
DE   AltName: Full=Ribosomal L24 domain-containing protein 1;
DE   AltName: Full=Ribosomal protein L24-like;
GN   Name=RSL24D1; Synonyms=C15orf15, RPL24L; ORFNames=My024;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Dendritic cell;
RA   Li Y., Peng Y., Li N., Gu W., Han Z., Fu G., Chen Z.;
RT   "Novel genes expressed in human dendritic cells.";
RL   Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Fetal brain;
RA   Mao Y.M., Xie Y., Lin Q., Mu Z.M., Yuan Y.Z.;
RL   Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Hematopoietic stem cell;
RA   Gu J., Huang Q., Yu Y., Xu S., Wang Y., Han Z., Chen Z., Zhou J.,
RA   Tu Y., Gu W., Fu G., Huang C.;
RT   "Novel genes expressed in hematopoietic stem/progenitor cells from
RT   myelodysplastic syndrome patients.";
RL   Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RA   Peng Y., Li Y., Tu Y., Xu S., Han Z., Fu G., Chen Z.;
RT   "A novel gene expressed in human liver.";
RL   Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT   "Cloning of human full open reading frames in Gateway(TM) system entry
RT   vector (pDONR201).";
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [8]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Blood, Bone marrow, Brain, Lung, and Urinary bladder;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [9]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=12429849; DOI=10.1091/mbc.E02-05-0271;
RA   Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C.,
RA   Greco A., Hochstrasser D.F., Diaz J.-J.;
RT   "Functional proteomic analysis of human nucleolus.";
RL   Mol. Biol. Cell 13:4100-4109(2002).
CC   -!- FUNCTION: Involved in the biogenesis of the 60S ribosomal subunit.
CC       Ensures the docking of GTPBP4/NOG1 to pre-60S particles (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Associated with nucleolar and cytoplasmic pre-60S
CC       particles. At the end of biogenesis it dissociates from
CC       cytoplasmic pre-60S particles and is likely to be exchanged for
CC       its ribosomal homolog, RPL24 (By similarity). {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q9UJX2:CDC23; NbExp=3; IntAct=EBI-749321, EBI-396137;
CC       Q9UJW3:DNMT3L; NbExp=6; IntAct=EBI-749321, EBI-740967;
CC       Q8IZU0:FAM9B; NbExp=3; IntAct=EBI-749321, EBI-10175124;
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000269|PubMed:12429849}.
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL24
CC       family. {ECO:0000305}.
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DR   EMBL; AF201949; AAF17241.1; -; mRNA.
DR   EMBL; AF060926; AAG43138.1; -; mRNA.
DR   EMBL; AF165521; AAF86651.1; -; mRNA.
DR   EMBL; AF212226; AAK26249.1; -; mRNA.
DR   EMBL; CR457179; CAG33460.1; -; mRNA.
DR   EMBL; AK315431; BAG37819.1; -; mRNA.
DR   EMBL; CH471082; EAW77473.1; -; Genomic_DNA.
DR   EMBL; BC008409; AAH08409.1; -; mRNA.
DR   EMBL; BC008422; AAH08422.1; -; mRNA.
DR   EMBL; BC008449; AAH08449.1; -; mRNA.
DR   EMBL; BC008499; AAH08499.1; -; mRNA.
DR   EMBL; BC009593; AAH09593.1; -; mRNA.
DR   EMBL; BC009604; AAH09604.1; -; mRNA.
DR   EMBL; BC012913; AAH12913.1; -; mRNA.
DR   EMBL; BC014576; AAH14576.1; -; mRNA.
DR   EMBL; BC016312; AAH16312.1; -; mRNA.
DR   EMBL; BC016331; AAH16331.1; -; mRNA.
DR   EMBL; BC016725; AAH16725.1; -; mRNA.
DR   EMBL; BC016777; AAH16777.1; -; mRNA.
DR   EMBL; BC026266; AAH26266.1; -; mRNA.
DR   EMBL; BC026267; AAH26267.1; -; mRNA.
DR   EMBL; BC028672; AAH28672.1; -; mRNA.
DR   EMBL; BC035995; AAH35995.1; -; mRNA.
DR   EMBL; BC093067; AAH93067.1; -; mRNA.
DR   CCDS; CCDS10152.1; -.
DR   RefSeq; NP_057388.1; NM_016304.2.
DR   UniGene; Hs.274772; -.
DR   ProteinModelPortal; Q9UHA3; -.
DR   SMR; Q9UHA3; -.
DR   BioGrid; 119362; 37.
DR   CORUM; Q9UHA3; -.
DR   IntAct; Q9UHA3; 5.
DR   STRING; 9606.ENSP00000260443; -.
DR   DrugBank; DB02494; Alpha-Hydroxy-Beta-Phenyl-Propionic Acid.
DR   DrugBank; DB07374; Anisomycin.
DR   DrugBank; DB08437; Puromycin.
DR   iPTMnet; Q9UHA3; -.
DR   PhosphoSitePlus; Q9UHA3; -.
DR   BioMuta; RSL24D1; -.
DR   DMDM; 52783333; -.
DR   SWISS-2DPAGE; Q9UHA3; -.
DR   EPD; Q9UHA3; -.
DR   jPOST; Q9UHA3; -.
DR   MaxQB; Q9UHA3; -.
DR   PaxDb; Q9UHA3; -.
DR   PeptideAtlas; Q9UHA3; -.
DR   PRIDE; Q9UHA3; -.
DR   ProteomicsDB; 84291; -.
DR   DNASU; 51187; -.
DR   Ensembl; ENST00000260443; ENSP00000260443; ENSG00000137876.
DR   GeneID; 51187; -.
DR   KEGG; hsa:51187; -.
DR   UCSC; uc002acn.4; human.
DR   CTD; 51187; -.
DR   EuPathDB; HostDB:ENSG00000137876.9; -.
DR   GeneCards; RSL24D1; -.
DR   HGNC; HGNC:18479; RSL24D1.
DR   HPA; HPA062724; -.
DR   HPA; HPA063392; -.
DR   MIM; 613262; gene.
DR   neXtProt; NX_Q9UHA3; -.
DR   OpenTargets; ENSG00000137876; -.
DR   PharmGKB; PA164725551; -.
DR   eggNOG; KOG1723; Eukaryota.
DR   eggNOG; COG2075; LUCA.
DR   GeneTree; ENSGT00550000074895; -.
DR   HOVERGEN; HBG105577; -.
DR   InParanoid; Q9UHA3; -.
DR   KO; K02896; -.
DR   OMA; KAPHAGK; -.
DR   OrthoDB; 1502432at2759; -.
DR   PhylomeDB; Q9UHA3; -.
DR   TreeFam; TF314926; -.
DR   ChiTaRS; RSL24D1; human.
DR   GeneWiki; C15orf15; -.
DR   GenomeRNAi; 51187; -.
DR   PRO; PR:Q9UHA3; -.
DR   Proteomes; UP000005640; Chromosome 15.
DR   Bgee; ENSG00000137876; Expressed in 232 organ(s), highest expression level in endometrium.
DR   CleanEx; HS_C15orf15; -.
DR   ExpressionAtlas; Q9UHA3; baseline and differential.
DR   Genevisible; Q9UHA3; HS.
DR   GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; IDA:HPA.
DR   GO; GO:0005634; C:nucleus; IDA:HPA.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR   GO; GO:1902626; P:assembly of large subunit precursor of preribosome; IBA:GO_Central.
DR   GO; GO:0000027; P:ribosomal large subunit assembly; IBA:GO_Central.
DR   GO; GO:0006412; P:translation; IBA:GO_Central.
DR   CDD; cd00472; Ribosomal_L24e_L24; 1.
DR   Gene3D; 2.30.170.20; -; 1.
DR   HAMAP; MF_00773; Ribosomal_L24e; 1.
DR   InterPro; IPR038630; L24e/L24_sf.
DR   InterPro; IPR023438; Ribosomal_L24e.
DR   InterPro; IPR000988; Ribosomal_L24e-rel.
DR   InterPro; IPR023442; Ribosomal_L24e_CS.
DR   InterPro; IPR011017; TRASH_dom.
DR   PANTHER; PTHR10792; PTHR10792; 1.
DR   Pfam; PF01246; Ribosomal_L24e; 1.
DR   SMART; SM00746; TRASH; 1.
DR   PROSITE; PS01073; RIBOSOMAL_L24E; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Nucleus; Reference proteome; Ribosome biogenesis.
FT   CHAIN         1    163       Probable ribosome biogenesis protein
FT                                RLP24.
FT                                /FTId=PRO_0000136896.
FT   CONFLICT     29     29       F -> I (in Ref. 8; AAH08499).
FT                                {ECO:0000305}.
FT   CONFLICT     30     30       R -> G (in Ref. 8; AAH14576).
FT                                {ECO:0000305}.
FT   CONFLICT     45     45       N -> D (in Ref. 8; AAH28672).
FT                                {ECO:0000305}.
FT   CONFLICT     86     86       W -> R (in Ref. 8; AAH16312).
FT                                {ECO:0000305}.
FT   CONFLICT    146    146       E -> G (in Ref. 8; AAH28672).
FT                                {ECO:0000305}.
SQ   SEQUENCE   163 AA;  19621 MW;  1E5D9ECFFCF678D1 CRC64;
     MRIEKCYFCS GPIYPGHGMM FVRNDCKVFR FCKSKCHKNF KKKRNPRKVR WTKAFRKAAG
     KELTVDNSFE FEKRRNEPIK YQRELWNKTI DAMKRVEEIK QKRQAKFIMN RLKKNKELQK
     VQDIKEVKQN IHLIRAPLAG KGKQLEEKMV QQLQEDVDME DAP
//