ID O12D3_HUMAN Reviewed; 316 AA. AC Q9UGF7; A2BDZ1; Q5SQI8; Q6IF23; DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-2000, sequence version 1. DT 27-MAR-2024, entry version 190. DE RecName: Full=Olfactory receptor 12D3; DE AltName: Full=Hs6M1-27; DE AltName: Full=Olfactory receptor OR6-27; GN Name=OR12D3; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Testis; RX PubMed=12637542; DOI=10.1074/jbc.m212424200; RA Volz A., Ehlers A., Younger R., Forbes S., Trowsdale J., Schnorr D., RA Beck S., Ziegler A.; RT "Complex transcription and splicing of odorant receptor genes."; RL J. Biol. Chem. 278:19691-19701(2003). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ILE-97. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., RA Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP IDENTIFICATION. RX PubMed=14983052; DOI=10.1073/pnas.0307882100; RA Malnic B., Godfrey P.A., Buck L.B.; RT "The human olfactory receptor gene family."; RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004). RN [5] RP ERRATUM OF PUBMED:14983052. RA Malnic B., Godfrey P.A., Buck L.B.; RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004). RN [6] RP VARIANT [LARGE SCALE ANALYSIS] LEU-250. RX PubMed=16959974; DOI=10.1126/science.1133427; RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V., RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., RA Velculescu V.E.; RT "The consensus coding sequences of human breast and colorectal cancers."; RL Science 314:268-274(2006). CC -!- FUNCTION: Odorant receptor. {ECO:0000305}. CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000255|PROSITE-ProRule:PRU00521}. CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE); CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR12D3"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ459858; CAD31041.1; -; mRNA. DR EMBL; AL096770; CAB65796.1; -; Genomic_DNA. DR EMBL; AL662781; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC069082; AAH69082.1; -; mRNA. DR EMBL; BC069154; AAH69154.1; -; mRNA. DR EMBL; BC103892; AAI03893.1; -; mRNA. DR EMBL; BC106898; -; NOT_ANNOTATED_CDS; mRNA. DR EMBL; BK004439; DAA04837.1; -; Genomic_DNA. DR CCDS; CCDS4658.1; -. DR RefSeq; NP_112221.1; NM_030959.2. DR AlphaFoldDB; Q9UGF7; -. DR SMR; Q9UGF7; -. DR BioGRID; 123588; 6. DR STRING; 9606.ENSP00000380023; -. DR GlyCosmos; Q9UGF7; 1 site, No reported glycans. DR GlyGen; Q9UGF7; 1 site. DR BioMuta; OR12D3; -. DR DMDM; 14423826; -. DR PaxDb; 9606-ENSP00000380023; -. DR PeptideAtlas; Q9UGF7; -. DR Antibodypedia; 35259; 93 antibodies from 21 providers. DR DNASU; 81797; -. DR Ensembl; ENST00000383556.7; ENSP00000373048.3; ENSG00000204692.9. DR Ensembl; ENST00000396806.3; ENSP00000380023.3; ENSG00000112462.8. DR Ensembl; ENST00000430148.5; ENSP00000393734.1; ENSG00000224487.8. DR Ensembl; ENST00000505384.5; ENSP00000421215.1; ENSG00000242022.8. DR Ensembl; ENST00000550681.1; ENSP00000449350.1; ENSG00000204692.9. DR Ensembl; ENST00000550913.1; ENSP00000447580.1; ENSG00000224487.8. DR Ensembl; ENST00000552446.1; ENSP00000447204.1; ENSG00000242022.8. DR GeneID; 81797; -. DR KEGG; hsa:81797; -. DR MANE-Select; ENST00000396806.3; ENSP00000380023.3; NM_030959.3; NP_112221.1. DR UCSC; uc003nme.3; human. DR AGR; HGNC:13963; -. DR CTD; 81797; -. DR DisGeNET; 81797; -. DR GeneCards; OR12D3; -. DR HGNC; HGNC:13963; OR12D3. DR HPA; ENSG00000112462; Not detected. DR neXtProt; NX_Q9UGF7; -. DR OpenTargets; ENSG00000112462; -. DR PharmGKB; PA32029; -. DR VEuPathDB; HostDB:ENSG00000112462; -. DR eggNOG; ENOG502SJ1M; Eukaryota. DR GeneTree; ENSGT00940000163236; -. DR HOGENOM; CLU_012526_1_2_1; -. DR InParanoid; Q9UGF7; -. DR OMA; MTQDRMV; -. DR OrthoDB; 5401587at2759; -. DR PhylomeDB; Q9UGF7; -. DR TreeFam; TF338273; -. DR PathwayCommons; Q9UGF7; -. DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors. DR BioGRID-ORCS; 81797; 11 hits in 737 CRISPR screens. DR GeneWiki; OR12D3; -. DR GenomeRNAi; 81797; -. DR Pharos; Q9UGF7; Tdark. DR PRO; PR:Q9UGF7; -. DR Proteomes; UP000005640; Chromosome 6. DR RNAct; Q9UGF7; Protein. DR Bgee; ENSG00000112462; Expressed in male germ line stem cell (sensu Vertebrata) in testis. DR ExpressionAtlas; Q9UGF7; baseline and differential. DR Genevisible; Q9UGF7; HS. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW. DR GO; GO:0005549; F:odorant binding; IBA:GO_Central. DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central. DR GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central. DR CDD; cd15915; 7tmA_OR12D-like; 1. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR000725; Olfact_rcpt. DR PANTHER; PTHR26452; OLFACTORY RECEPTOR; 1. DR PANTHER; PTHR26452:SF802; OLFACTORY RECEPTOR; 1. DR Pfam; PF13853; 7tm_4; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 2: Evidence at transcript level; KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein; KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction; KW Transducer; Transmembrane; Transmembrane helix. FT CHAIN 1..316 FT /note="Olfactory receptor 12D3" FT /id="PRO_0000150729" FT TOPO_DOM 1..23 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 24..44 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TOPO_DOM 45..52 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 53..73 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TOPO_DOM 74..97 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 98..118 FT /note="Helical; Name=3" FT /evidence="ECO:0000255" FT TOPO_DOM 119..137 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 138..158 FT /note="Helical; Name=4" FT /evidence="ECO:0000255" FT TOPO_DOM 159..195 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 196..215 FT /note="Helical; Name=5" FT /evidence="ECO:0000255" FT TOPO_DOM 216..236 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 237..257 FT /note="Helical; Name=6" FT /evidence="ECO:0000255" FT TOPO_DOM 258..270 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 271..291 FT /note="Helical; Name=7" FT /evidence="ECO:0000255" FT TOPO_DOM 292..316 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT CARBOHYD 3 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 95..187 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521" FT VARIANT 97 FT /note="T -> I (in dbSNP:rs3749971)" FT /evidence="ECO:0000269|PubMed:14574404" FT /id="VAR_020383" FT VARIANT 250 FT /note="F -> L (in a breast cancer sample; somatic mutation; FT dbSNP:rs545611345)" FT /evidence="ECO:0000269|PubMed:16959974" FT /id="VAR_036209" FT VARIANT 277 FT /note="Y -> H (in dbSNP:rs9380122)" FT /id="VAR_053298" SQ SEQUENCE 316 AA; 35791 MW; 07FDCF869D8989B2 CRC64; MENVTTMNEF LLLGLTGVQE LQPFFFGIFL IIYLINLIGN GSILVMVVLE PQLHSPMYFF LGNLSCLDIS YSSVTLPKLL VNLVCSRRAI SFLGCITQLH FFHFLGSTEA ILLAIMAFDR FVAICNPLRY TVIMNPQVCI LLAAAAWLIS FFYALMHSVM TAHLSFCGSQ KLNHFFYDVK PLLELACSDT LLNQWLLSIV TGSISMGAFF LTLLSCFYVI GFLLFKNRSC RILHKALSTC ASHFMVVCLF YGPVGFTYIR PASATSMIQD RIMAIMYSAV TPVLNPLIYT LRNKEVMMAL KKIFGRKLFK DWQQHH //