ID O12D3_HUMAN Reviewed; 316 AA. AC Q9UGF7; A2BDZ1; Q5SQI8; Q6IF23; DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-2000, sequence version 1. DT 01-MAY-2013, entry version 116. DE RecName: Full=Olfactory receptor 12D3; DE AltName: Full=Hs6M1-27; DE AltName: Full=Olfactory receptor OR6-27; GN Name=OR12D3; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Testis; RX PubMed=12637542; DOI=10.1074/jbc.M212424200; RA Volz A., Ehlers A., Younger R., Forbes S., Trowsdale J., Schnorr D., RA Beck S., Ziegler A.; RT "Complex transcription and splicing of odorant receptor genes."; RL J. Biol. Chem. 278:19691-19701(2003). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ILE-97. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP IDENTIFICATION. RX PubMed=14983052; DOI=10.1073/pnas.0307882100; RA Malnic B., Godfrey P.A., Buck L.B.; RT "The human olfactory receptor gene family."; RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004). RN [5] RP ERRATUM. RA Malnic B., Godfrey P.A., Buck L.B.; RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004). RN [6] RP VARIANT [LARGE SCALE ANALYSIS] LEU-250. RX PubMed=16959974; DOI=10.1126/science.1133427; RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., RA Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., RA Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C., RA Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., RA Vogelstein B., Kinzler K.W., Velculescu V.E.; RT "The consensus coding sequences of human breast and colorectal RT cancers."; RL Science 314:268-274(2006). CC -!- FUNCTION: Odorant receptor (Potential). CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium CC (HORDE); CC URL="http://bip.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR12D3"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ459858; CAD31041.1; -; mRNA. DR EMBL; AL096770; CAB65796.1; -; Genomic_DNA. DR EMBL; AL662781; CAI18132.1; -; Genomic_DNA. DR EMBL; BC069082; AAH69082.1; -; mRNA. DR EMBL; BC069154; AAH69154.1; -; mRNA. DR EMBL; BC103892; AAI03893.1; -; mRNA. DR EMBL; BC106898; -; NOT_ANNOTATED_CDS; mRNA. DR EMBL; BK004439; DAA04837.1; -; Genomic_DNA. DR IPI; IPI00005290; -. DR RefSeq; NP_112221.1; NM_030959.2. DR UniGene; Hs.272280; -. DR ProteinModelPortal; Q9UGF7; -. DR DMDM; 14423826; -. DR PaxDb; Q9UGF7; -. DR PRIDE; Q9UGF7; -. DR Ensembl; ENST00000377143; ENSP00000366348; ENSG00000112462. DR Ensembl; ENST00000383556; ENSP00000373048; ENSG00000204692. DR Ensembl; ENST00000396806; ENSP00000380023; ENSG00000112462. DR Ensembl; ENST00000430148; ENSP00000393734; ENSG00000224487. DR Ensembl; ENST00000505384; ENSP00000421215; ENSG00000242022. DR Ensembl; ENST00000550681; ENSP00000449350; ENSG00000204692. DR Ensembl; ENST00000550913; ENSP00000447580; ENSG00000224487. DR Ensembl; ENST00000552446; ENSP00000447204; ENSG00000242022. DR GeneID; 81797; -. DR KEGG; hsa:81797; -. DR UCSC; uc003nme.3; human. DR CTD; 81797; -. DR GeneCards; GC06M029346; -. DR H-InvDB; HIX0166575; -. DR H-InvDB; HIX0166829; -. DR HGNC; HGNC:13963; OR12D3. DR neXtProt; NX_Q9UGF7; -. DR PharmGKB; PA32029; -. DR eggNOG; NOG303914; -. DR HOGENOM; HOG000041362; -. DR HOVERGEN; HBG017625; -. DR KO; K04257; -. DR OMA; VTTMNEF; -. DR OrthoDB; EOG43TZW2; -. DR PhylomeDB; Q9UGF7; -. DR GenomeRNAi; 81797; -. DR NextBio; 72118; -. DR ArrayExpress; Q9UGF7; -. DR Bgee; Q9UGF7; -. DR CleanEx; HS_OR12D3; -. DR Genevestigator; Q9UGF7; -. DR GermOnline; ENSG00000204692; Homo sapiens. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW. DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro. DR GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IEA:GOC. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR000725; Olfact_rcpt. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 2: Evidence at transcript level; KW Cell membrane; Complete proteome; Disulfide bond; KW G-protein coupled receptor; Glycoprotein; Membrane; Olfaction; KW Polymorphism; Receptor; Reference proteome; Sensory transduction; KW Transducer; Transmembrane; Transmembrane helix. FT CHAIN 1 316 Olfactory receptor 12D3. FT /FTId=PRO_0000150729. FT TOPO_DOM 1 23 Extracellular (Potential). FT TRANSMEM 24 44 Helical; Name=1; (Potential). FT TOPO_DOM 45 52 Cytoplasmic (Potential). FT TRANSMEM 53 73 Helical; Name=2; (Potential). FT TOPO_DOM 74 97 Extracellular (Potential). FT TRANSMEM 98 118 Helical; Name=3; (Potential). FT TOPO_DOM 119 137 Cytoplasmic (Potential). FT TRANSMEM 138 158 Helical; Name=4; (Potential). FT TOPO_DOM 159 195 Extracellular (Potential). FT TRANSMEM 196 215 Helical; Name=5; (Potential). FT TOPO_DOM 216 236 Cytoplasmic (Potential). FT TRANSMEM 237 257 Helical; Name=6; (Potential). FT TOPO_DOM 258 270 Extracellular (Potential). FT TRANSMEM 271 291 Helical; Name=7; (Potential). FT TOPO_DOM 292 316 Cytoplasmic (Potential). FT CARBOHYD 3 3 N-linked (GlcNAc...) (Potential). FT DISULFID 95 187 By similarity. FT VARIANT 97 97 T -> I (in dbSNP:rs3749971). FT /FTId=VAR_020383. FT VARIANT 250 250 F -> L (in a breast cancer sample; FT somatic mutation). FT /FTId=VAR_036209. FT VARIANT 277 277 Y -> H (in dbSNP:rs9380122). FT /FTId=VAR_053298. SQ SEQUENCE 316 AA; 35791 MW; 07FDCF869D8989B2 CRC64; MENVTTMNEF LLLGLTGVQE LQPFFFGIFL IIYLINLIGN GSILVMVVLE PQLHSPMYFF LGNLSCLDIS YSSVTLPKLL VNLVCSRRAI SFLGCITQLH FFHFLGSTEA ILLAIMAFDR FVAICNPLRY TVIMNPQVCI LLAAAAWLIS FFYALMHSVM TAHLSFCGSQ KLNHFFYDVK PLLELACSDT LLNQWLLSIV TGSISMGAFF LTLLSCFYVI GFLLFKNRSC RILHKALSTC ASHFMVVCLF YGPVGFTYIR PASATSMIQD RIMAIMYSAV TPVLNPLIYT LRNKEVMMAL KKIFGRKLFK DWQQHH //