ID LPAR3_HUMAN Reviewed; 353 AA. AC Q9UBY5; A0AVA3; DT 06-DEC-2002, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-2000, sequence version 1. DT 08-NOV-2023, entry version 176. DE RecName: Full=Lysophosphatidic acid receptor 3; DE Short=LPA receptor 3; DE Short=LPA-3; DE AltName: Full=Lysophosphatidic acid receptor Edg-7; GN Name=LPAR3; Synonyms=EDG7, LPA3; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=T-cell; RX PubMed=10488122; DOI=10.1074/jbc.274.39.27776; RA Bandoh K., Aoki J., Hosono H., Kobayashi S., Kobayashi T., RA Murakami-Murofushi K., Tsujimoto M., Arai H., Inoue K.; RT "Molecular cloning and characterization of a novel human G-protein-coupled RT receptor, EDG7, for lysophosphatidic acid."; RL J. Biol. Chem. 274:27776-27785(1999). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Embryonic kidney; RX PubMed=10727522; DOI=10.1124/mol.57.4.753; RA Im D.-S., Heise C.E., Harding M.A., George S.R., O'Dowd B.F., RA Theodorescu D., Lynch K.R.; RT "Molecular cloning and characterization of a lysophosphatidic acid RT receptor, Edg-7, expressed in prostate."; RL Mol. Pharmacol. 57:753-759(2000). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Testis; RA Kopatz S.A., Aronstam R.S., Sharma S.V.; RT "cDNA clones of human proteins involved in signal transduction sequenced by RT the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [5] RP REVIEW. RX PubMed=11093753; DOI=10.1124/mol.58.6.1188; RA Contos J.J.A., Ishii I., Chun J.; RT "Lysophosphatidic acid receptors."; RL Mol. Pharmacol. 58:1188-1196(2000). CC -!- FUNCTION: Receptor for lysophosphatidic acid (LPA), a mediator of CC diverse cellular activities. May play a role in the development of CC ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families CC of heteromeric G proteins. CC -!- INTERACTION: CC Q9UBY5; Q13520: AQP6; NbExp=3; IntAct=EBI-12033434, EBI-13059134; CC Q9UBY5; Q3SXY8: ARL13B; NbExp=3; IntAct=EBI-12033434, EBI-11343438; CC Q9UBY5; Q8WWH4: ASZ1; NbExp=3; IntAct=EBI-12033434, EBI-12239061; CC Q9UBY5; Q9BXK5: BCL2L13; NbExp=3; IntAct=EBI-12033434, EBI-747430; CC Q9UBY5; Q6UWD8: C16orf54; NbExp=3; IntAct=EBI-12033434, EBI-18041102; CC Q9UBY5; P19397: CD53; NbExp=3; IntAct=EBI-12033434, EBI-6657396; CC Q9UBY5; P04233-2: CD74; NbExp=4; IntAct=EBI-12033434, EBI-12222807; CC Q9UBY5; P11912: CD79A; NbExp=3; IntAct=EBI-12033434, EBI-7797864; CC Q9UBY5; P57739: CLDN2; NbExp=3; IntAct=EBI-12033434, EBI-751440; CC Q9UBY5; O95471: CLDN7; NbExp=3; IntAct=EBI-12033434, EBI-740744; CC Q9UBY5; O95484: CLDN9; NbExp=3; IntAct=EBI-12033434, EBI-18341636; CC Q9UBY5; Q2HXU8-2: CLEC12B; NbExp=3; IntAct=EBI-12033434, EBI-12811991; CC Q9UBY5; Q7Z7G2: CPLX4; NbExp=3; IntAct=EBI-12033434, EBI-18013275; CC Q9UBY5; Q96BA8: CREB3L1; NbExp=5; IntAct=EBI-12033434, EBI-6942903; CC Q9UBY5; P49447: CYB561; NbExp=3; IntAct=EBI-12033434, EBI-8646596; CC Q9UBY5; Q53TN4: CYBRD1; NbExp=3; IntAct=EBI-12033434, EBI-8637742; CC Q9UBY5; Q92838: EDA; NbExp=3; IntAct=EBI-12033434, EBI-529425; CC Q9UBY5; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-12033434, EBI-781551; CC Q9UBY5; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-12033434, EBI-18304435; CC Q9UBY5; Q96KR6: FAM210B; NbExp=3; IntAct=EBI-12033434, EBI-18938272; CC Q9UBY5; O15552: FFAR2; NbExp=3; IntAct=EBI-12033434, EBI-2833872; CC Q9UBY5; Q8TBE3: FNDC9; NbExp=3; IntAct=EBI-12033434, EBI-12142257; CC Q9UBY5; O95377: GJB5; NbExp=3; IntAct=EBI-12033434, EBI-3909454; CC Q9UBY5; Q5T7V8: GORAB; NbExp=3; IntAct=EBI-12033434, EBI-3917143; CC Q9UBY5; Q8TED1: GPX8; NbExp=3; IntAct=EBI-12033434, EBI-11721746; CC Q9UBY5; Q8N5M9: JAGN1; NbExp=3; IntAct=EBI-12033434, EBI-10266796; CC Q9UBY5; P48547: KCNC1; NbExp=3; IntAct=EBI-12033434, EBI-12830942; CC Q9UBY5; P48051: KCNJ6; NbExp=3; IntAct=EBI-12033434, EBI-12017638; CC Q9UBY5; O95214: LEPROTL1; NbExp=3; IntAct=EBI-12033434, EBI-750776; CC Q9UBY5; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-12033434, EBI-2820517; CC Q9UBY5; Q9H400: LIME1; NbExp=3; IntAct=EBI-12033434, EBI-2830566; CC Q9UBY5; Q9GZY8-5: MFF; NbExp=3; IntAct=EBI-12033434, EBI-11956541; CC Q9UBY5; O14880: MGST3; NbExp=3; IntAct=EBI-12033434, EBI-724754; CC Q9UBY5; Q6IN84: MRM1; NbExp=3; IntAct=EBI-12033434, EBI-5454865; CC Q9UBY5; Q96JQ5: MS4A4A; NbExp=3; IntAct=EBI-12033434, EBI-12820341; CC Q9UBY5; Q8N183: NDUFAF2; NbExp=3; IntAct=EBI-12033434, EBI-2682365; CC Q9UBY5; P35372-10: OPRM1; NbExp=3; IntAct=EBI-12033434, EBI-12807478; CC Q9UBY5; O15173: PGRMC2; NbExp=3; IntAct=EBI-12033434, EBI-1050125; CC Q9UBY5; Q8NC24: RELL2; NbExp=3; IntAct=EBI-12033434, EBI-10269209; CC Q9UBY5; Q86VR2: RETREG3; NbExp=5; IntAct=EBI-12033434, EBI-10192441; CC Q9UBY5; Q9NY72: SCN3B; NbExp=3; IntAct=EBI-12033434, EBI-17247926; CC Q9UBY5; Q8NHU3: SGMS2; NbExp=3; IntAct=EBI-12033434, EBI-10977284; CC Q9UBY5; Q3SXP7: SHISAL1; NbExp=3; IntAct=EBI-12033434, EBI-18037857; CC Q9UBY5; Q3KNW5: SLC10A6; NbExp=3; IntAct=EBI-12033434, EBI-18159983; CC Q9UBY5; Q9NQQ7-3: SLC35C2; NbExp=3; IntAct=EBI-12033434, EBI-17295964; CC Q9UBY5; O14948-3: TFEC; NbExp=3; IntAct=EBI-12033434, EBI-12246506; CC Q9UBY5; Q8WY91: THAP4; NbExp=3; IntAct=EBI-12033434, EBI-726691; CC Q9UBY5; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-12033434, EBI-8638294; CC Q9UBY5; Q96Q45-2: TMEM237; NbExp=3; IntAct=EBI-12033434, EBI-10982110; CC Q9UBY5; Q96HV5: TMEM41A; NbExp=3; IntAct=EBI-12033434, EBI-10288884; CC Q9UBY5; Q4KMG9: TMEM52B; NbExp=3; IntAct=EBI-12033434, EBI-18178701; CC Q9UBY5; Q9BUB7: TMEM70; NbExp=3; IntAct=EBI-12033434, EBI-726363; CC Q9UBY5; Q9BSE2: TMEM79; NbExp=3; IntAct=EBI-12033434, EBI-8649725; CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Most abundantly expressed in prostate, testes, CC pancreas, and heart, with moderate levels in lung and ovary. No CC detectable expression in brain, placenta, liver, skeletal muscle, CC kidney, spleen, thymus, small intestine, colon, or peripheral blood CC leukocytes. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000255|PROSITE-ProRule:PRU00521}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF127138; AAD56311.1; -; mRNA. DR EMBL; AF186380; AAF00530.1; -; mRNA. DR EMBL; AY322547; AAP84360.1; -; mRNA. DR EMBL; BC126268; AAI26269.1; -; mRNA. DR EMBL; BC126270; AAI26271.1; -; mRNA. DR CCDS; CCDS700.1; -. DR RefSeq; NP_036284.1; NM_012152.2. DR AlphaFoldDB; Q9UBY5; -. DR SMR; Q9UBY5; -. DR BioGRID; 117108; 98. DR IntAct; Q9UBY5; 53. DR STRING; 9606.ENSP00000395389; -. DR BindingDB; Q9UBY5; -. DR ChEMBL; CHEMBL3250; -. DR GuidetoPHARMACOLOGY; 274; -. DR SwissLipids; SLP:000001572; -. DR GlyCosmos; Q9UBY5; 2 sites, No reported glycans. DR GlyGen; Q9UBY5; 2 sites. DR iPTMnet; Q9UBY5; -. DR PhosphoSitePlus; Q9UBY5; -. DR SwissPalm; Q9UBY5; -. DR BioMuta; LPAR3; -. DR DMDM; 26393418; -. DR MassIVE; Q9UBY5; -. DR PaxDb; 9606-ENSP00000395389; -. DR PeptideAtlas; Q9UBY5; -. DR ProteomicsDB; 84099; -. DR Antibodypedia; 2955; 359 antibodies from 35 providers. DR DNASU; 23566; -. DR Ensembl; ENST00000370611.4; ENSP00000359643.3; ENSG00000171517.6. DR Ensembl; ENST00000440886.1; ENSP00000395389.1; ENSG00000171517.6. DR GeneID; 23566; -. DR KEGG; hsa:23566; -. DR MANE-Select; ENST00000370611.4; ENSP00000359643.3; NM_012152.3; NP_036284.1. DR UCSC; uc001dkl.3; human. DR AGR; HGNC:14298; -. DR CTD; 23566; -. DR DisGeNET; 23566; -. DR GeneCards; LPAR3; -. DR HGNC; HGNC:14298; LPAR3. DR HPA; ENSG00000171517; Tissue enhanced (fallopian). DR MIM; 605106; gene. DR neXtProt; NX_Q9UBY5; -. DR OpenTargets; ENSG00000171517; -. DR PharmGKB; PA162394213; -. DR VEuPathDB; HostDB:ENSG00000171517; -. DR eggNOG; KOG3656; Eukaryota. DR GeneTree; ENSGT01050000244941; -. DR HOGENOM; CLU_047979_0_0_1; -. DR InParanoid; Q9UBY5; -. DR OMA; DDEMWAT; -. DR OrthoDB; 5349764at2759; -. DR PhylomeDB; Q9UBY5; -. DR TreeFam; TF330052; -. DR PathwayCommons; Q9UBY5; -. DR Reactome; R-HSA-416476; G alpha (q) signalling events. DR Reactome; R-HSA-418594; G alpha (i) signalling events. DR Reactome; R-HSA-419408; Lysosphingolipid and LPA receptors. DR SignaLink; Q9UBY5; -. DR SIGNOR; Q9UBY5; -. DR BioGRID-ORCS; 23566; 10 hits in 1146 CRISPR screens. DR ChiTaRS; LPAR3; human. DR GeneWiki; LPAR3; -. DR GenomeRNAi; 23566; -. DR Pharos; Q9UBY5; Tchem. DR PRO; PR:Q9UBY5; -. DR Proteomes; UP000005640; Chromosome 1. DR RNAct; Q9UBY5; Protein. DR Bgee; ENSG00000171517; Expressed in bronchial epithelial cell and 134 other tissues. DR Genevisible; Q9UBY5; HS. DR GO; GO:0030424; C:axon; IEA:Ensembl. DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central. DR GO; GO:0005886; C:plasma membrane; IDA:HPA. DR GO; GO:0045202; C:synapse; IEA:GOC. DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central. DR GO; GO:0008289; F:lipid binding; TAS:ProtInc. DR GO; GO:0070915; F:lysophosphatidic acid receptor activity; IEA:InterPro. DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central. DR GO; GO:0032060; P:bleb assembly; IEA:Ensembl. DR GO; GO:0007268; P:chemical synaptic transmission; TAS:ProtInc. DR GO; GO:0048668; P:collateral sprouting; IEA:Ensembl. DR GO; GO:0007187; P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; TAS:ProtInc. DR GO; GO:0010467; P:gene expression; IEA:Ensembl. DR GO; GO:0048672; P:positive regulation of collateral sprouting; IEA:Ensembl. DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; TAS:ProtInc. DR GO; GO:0043410; P:positive regulation of MAPK cascade; IEA:Ensembl. DR GO; GO:0019222; P:regulation of metabolic process; IBA:GO_Central. DR CDD; cd15343; 7tmA_LPAR3_Edg7; 1. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR004065; LPA_rcpt. DR InterPro; IPR005385; LPA_rcpt_EDG7. DR PANTHER; PTHR22750; G-PROTEIN COUPLED RECEPTOR; 1. DR PANTHER; PTHR22750:SF21; LYSOPHOSPHATIDIC ACID RECEPTOR 3; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01560; EDG7RECEPTOR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01527; LPARECEPTOR. DR SMART; SM01381; 7TM_GPCR_Srsx; 1. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 1: Evidence at protein level; KW Cell membrane; G-protein coupled receptor; Glycoprotein; Lipoprotein; KW Membrane; Palmitate; Receptor; Reference proteome; Transducer; KW Transmembrane; Transmembrane helix. FT CHAIN 1..353 FT /note="Lysophosphatidic acid receptor 3" FT /id="PRO_0000069433" FT TOPO_DOM 1..31 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 32..52 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TOPO_DOM 53..67 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 68..88 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TOPO_DOM 89..101 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 102..124 FT /note="Helical; Name=3" FT /evidence="ECO:0000255" FT TOPO_DOM 125..146 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 147..167 FT /note="Helical; Name=4" FT /evidence="ECO:0000255" FT TOPO_DOM 168..186 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 187..207 FT /note="Helical; Name=5" FT /evidence="ECO:0000255" FT TOPO_DOM 208..240 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 241..261 FT /note="Helical; Name=6" FT /evidence="ECO:0000255" FT TOPO_DOM 262..276 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 277..297 FT /note="Helical; Name=7" FT /evidence="ECO:0000255" FT TOPO_DOM 298..353 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT LIPID 309 FT /note="S-palmitoyl cysteine" FT /evidence="ECO:0000250" FT CARBOHYD 15 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 172 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT VARIANT 231 FT /note="R -> Q (in dbSNP:rs35745543)" FT /id="VAR_049415" SQ SEQUENCE 353 AA; 40128 MW; 105DC9DD185E2CE7 CRC64; MNECHYDKHM DFFYNRSNTD TVDDWTGTKL VIVLCVGTFF CLFIFFSNSL VIAAVIKNRK FHFPFYYLLA NLAAADFFAG IAYVFLMFNT GPVSKTLTVN RWFLRQGLLD SSLTASLTNL LVIAVERHMS IMRMRVHSNL TKKRVTLLIL LVWAIAIFMG AVPTLGWNCL CNISACSSLA PIYSRSYLVF WTVSNLMAFL IMVVVYLRIY VYVKRKTNVL SPHTSGSISR RRTPMKLMKT VMTVLGAFVV CWTPGLVVLL LDGLNCRQCG VQHVKRWFLL LALLNSVVNP IIYSYKDEDM YGTMKKMICC FSQENPERRP SRIPSTVLSR SDTGSQYIED SISQGAVCNK STS //