ID LPAR3_HUMAN Reviewed; 353 AA. AC Q9UBY5; A0AVA3; DT 06-DEC-2002, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-2000, sequence version 1. DT 30-AUG-2017, entry version 138. DE RecName: Full=Lysophosphatidic acid receptor 3; DE Short=LPA receptor 3; DE Short=LPA-3; DE AltName: Full=Lysophosphatidic acid receptor Edg-7; GN Name=LPAR3; Synonyms=EDG7, LPA3; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=T-cell; RX PubMed=10488122; DOI=10.1074/jbc.274.39.27776; RA Bandoh K., Aoki J., Hosono H., Kobayashi S., Kobayashi T., RA Murakami-Murofushi K., Tsujimoto M., Arai H., Inoue K.; RT "Molecular cloning and characterization of a novel human G-protein- RT coupled receptor, EDG7, for lysophosphatidic acid."; RL J. Biol. Chem. 274:27776-27785(1999). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Embryonic kidney; RX PubMed=10727522; RA Im D.-S., Heise C.E., Harding M.A., George S.R., O'Dowd B.F., RA Theodorescu D., Lynch K.R.; RT "Molecular cloning and characterization of a lysophosphatidic acid RT receptor, Edg-7, expressed in prostate."; RL Mol. Pharmacol. 57:753-759(2000). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Testis; RA Kopatz S.A., Aronstam R.S., Sharma S.V.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [5] RP REVIEW. RX PubMed=11093753; RA Contos J.J.A., Ishii I., Chun J.; RT "Lysophosphatidic acid receptors."; RL Mol. Pharmacol. 58:1188-1196(2000). CC -!- FUNCTION: Receptor for lysophosphatidic acid (LPA), a mediator of CC diverse cellular activities. May play a role in the development of CC ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) CC families of heteromeric G proteins. CC -!- INTERACTION: CC Q9BXK5:BCL2L13; NbExp=4; IntAct=EBI-12033434, EBI-747430; CC Q2HXU8-2:CLEC12B; NbExp=4; IntAct=EBI-12033434, EBI-12811991; CC Q96JQ5:MS4A4A; NbExp=4; IntAct=EBI-12033434, EBI-12820341; CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Most abundantly expressed in prostate, testes, CC pancreas, and heart, with moderate levels in lung and ovary. No CC detectable expression in brain, placenta, liver, skeletal muscle, CC kidney, spleen, thymus, small intestine, colon, or peripheral CC blood leukocytes. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000255|PROSITE-ProRule:PRU00521}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF127138; AAD56311.1; -; mRNA. DR EMBL; AF186380; AAF00530.1; -; mRNA. DR EMBL; AY322547; AAP84360.1; -; mRNA. DR EMBL; BC126268; AAI26269.1; -; mRNA. DR EMBL; BC126270; AAI26271.1; -; mRNA. DR CCDS; CCDS700.1; -. DR RefSeq; NP_036284.1; NM_012152.2. DR UniGene; Hs.527909; -. DR UniGene; Hs.674915; -. DR ProteinModelPortal; Q9UBY5; -. DR BioGrid; 117108; 2. DR IntAct; Q9UBY5; 16. DR STRING; 9606.ENSP00000359643; -. DR BindingDB; Q9UBY5; -. DR ChEMBL; CHEMBL3250; -. DR GuidetoPHARMACOLOGY; 274; -. DR SwissLipids; SLP:000001572; -. DR iPTMnet; Q9UBY5; -. DR PhosphoSitePlus; Q9UBY5; -. DR BioMuta; LPAR3; -. DR DMDM; 26393418; -. DR PaxDb; Q9UBY5; -. DR PeptideAtlas; Q9UBY5; -. DR PRIDE; Q9UBY5; -. DR Ensembl; ENST00000370611; ENSP00000359643; ENSG00000171517. DR Ensembl; ENST00000440886; ENSP00000395389; ENSG00000171517. DR GeneID; 23566; -. DR KEGG; hsa:23566; -. DR UCSC; uc001dkl.3; human. DR CTD; 23566; -. DR DisGeNET; 23566; -. DR GeneCards; LPAR3; -. DR HGNC; HGNC:14298; LPAR3. DR HPA; HPA013421; -. DR MIM; 605106; gene. DR neXtProt; NX_Q9UBY5; -. DR OpenTargets; ENSG00000171517; -. DR PharmGKB; PA162394213; -. DR eggNOG; KOG3656; Eukaryota. DR eggNOG; ENOG410XRW9; LUCA. DR GeneTree; ENSGT00760000118804; -. DR HOVERGEN; HBG103071; -. DR InParanoid; Q9UBY5; -. DR KO; K04294; -. DR OMA; HSNLTKR; -. DR OrthoDB; EOG091G0DD4; -. DR PhylomeDB; Q9UBY5; -. DR TreeFam; TF330052; -. DR Reactome; R-HSA-416476; G alpha (q) signalling events. DR Reactome; R-HSA-418594; G alpha (i) signalling events. DR Reactome; R-HSA-419408; Lysosphingolipid and LPA receptors. DR SIGNOR; Q9UBY5; -. DR ChiTaRS; LPAR3; human. DR GeneWiki; LPAR3; -. DR GenomeRNAi; 23566; -. DR PRO; PR:Q9UBY5; -. DR Proteomes; UP000005640; Chromosome 1. DR Bgee; ENSG00000171517; -. DR CleanEx; HS_LPAR3; -. DR Genevisible; Q9UBY5; HS. DR GO; GO:0030424; C:axon; IEA:Ensembl. DR GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc. DR GO; GO:0005886; C:plasma membrane; IDA:HPA. DR GO; GO:0001965; F:G-protein alpha-subunit binding; IEA:Ensembl. DR GO; GO:0004930; F:G-protein coupled receptor activity; TAS:ProtInc. DR GO; GO:0008289; F:lipid binding; TAS:ProtInc. DR GO; GO:0070915; F:lysophosphatidic acid receptor activity; IEA:InterPro. DR GO; GO:0005543; F:phospholipid binding; IEA:Ensembl. DR GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl. DR GO; GO:0032060; P:bleb assembly; IEA:Ensembl. DR GO; GO:0007268; P:chemical synaptic transmission; TAS:ProtInc. DR GO; GO:0007187; P:G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; TAS:ProtInc. DR GO; GO:0051928; P:positive regulation of calcium ion transport; IEA:Ensembl. DR GO; GO:0048672; P:positive regulation of collateral sprouting; IEA:Ensembl. DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; TAS:ProtInc. DR GO; GO:0051482; P:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway; IEA:Ensembl. DR CDD; cd15343; 7tmA_LPAR3_Edg7; 1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR004065; LPA_rcpt. DR InterPro; IPR005385; LPA_rcpt_EDG7. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01560; EDG7RECEPTOR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01527; LPARECEPTOR. DR SMART; SM01381; 7TM_GPCR_Srsx; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 1: Evidence at protein level; KW Cell membrane; Complete proteome; G-protein coupled receptor; KW Glycoprotein; Lipoprotein; Membrane; Palmitate; Polymorphism; KW Receptor; Reference proteome; Transducer; Transmembrane; KW Transmembrane helix. FT CHAIN 1 353 Lysophosphatidic acid receptor 3. FT /FTId=PRO_0000069433. FT TOPO_DOM 1 31 Extracellular. {ECO:0000255}. FT TRANSMEM 32 52 Helical; Name=1. {ECO:0000255}. FT TOPO_DOM 53 67 Cytoplasmic. {ECO:0000255}. FT TRANSMEM 68 88 Helical; Name=2. {ECO:0000255}. FT TOPO_DOM 89 101 Extracellular. {ECO:0000255}. FT TRANSMEM 102 124 Helical; Name=3. {ECO:0000255}. FT TOPO_DOM 125 146 Cytoplasmic. {ECO:0000255}. FT TRANSMEM 147 167 Helical; Name=4. {ECO:0000255}. FT TOPO_DOM 168 186 Extracellular. {ECO:0000255}. FT TRANSMEM 187 207 Helical; Name=5. {ECO:0000255}. FT TOPO_DOM 208 240 Cytoplasmic. {ECO:0000255}. FT TRANSMEM 241 261 Helical; Name=6. {ECO:0000255}. FT TOPO_DOM 262 276 Extracellular. {ECO:0000255}. FT TRANSMEM 277 297 Helical; Name=7. {ECO:0000255}. FT TOPO_DOM 298 353 Cytoplasmic. {ECO:0000255}. FT LIPID 309 309 S-palmitoyl cysteine. {ECO:0000250}. FT CARBOHYD 15 15 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 172 172 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT VARIANT 231 231 R -> Q (in dbSNP:rs35745543). FT /FTId=VAR_049415. SQ SEQUENCE 353 AA; 40128 MW; 105DC9DD185E2CE7 CRC64; MNECHYDKHM DFFYNRSNTD TVDDWTGTKL VIVLCVGTFF CLFIFFSNSL VIAAVIKNRK FHFPFYYLLA NLAAADFFAG IAYVFLMFNT GPVSKTLTVN RWFLRQGLLD SSLTASLTNL LVIAVERHMS IMRMRVHSNL TKKRVTLLIL LVWAIAIFMG AVPTLGWNCL CNISACSSLA PIYSRSYLVF WTVSNLMAFL IMVVVYLRIY VYVKRKTNVL SPHTSGSISR RRTPMKLMKT VMTVLGAFVV CWTPGLVVLL LDGLNCRQCG VQHVKRWFLL LALLNSVVNP IIYSYKDEDM YGTMKKMICC FSQENPERRP SRIPSTVLSR SDTGSQYIED SISQGAVCNK STS //