ID Q9U4I2_DROME Unreviewed; 3469 AA. AC Q9U4I2; DT 01-MAY-2000, integrated into UniProtKB/TrEMBL. DT 01-MAY-2000, sequence version 1. DT 17-JUN-2020, entry version 125. DE SubName: Full=SANT domain protein SMRTER {ECO:0000313|EMBL:AAD52614.1}; GN Name=Smr {ECO:0000313|FlyBase:FBgn0265523}; GN Synonyms=Smrter {ECO:0000313|EMBL:AAD52614.1}; GN ORFNames=CG4013 {ECO:0000313|FlyBase:FBgn0265523}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAD52614.1}; RN [1] {ECO:0000313|EMBL:AAD52614.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=10488333; DOI=10.1016/S1097-2765(00)80365-2; RA Tsai C.C., Kao H.Y., Yao T.P., McKeown M., Evans R.M.; RT "SMRTER, a Drosophila nuclear receptor coregulator, reveals that EcR- RT mediated repression is critical for development."; RL Mol. Cell 4:175-186(1999). CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|SAAS:SAAS00548613}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF175223; AAD52614.1; -; mRNA. DR PeptideAtlas; Q9U4I2; -. DR PRIDE; Q9U4I2; -. DR FlyBase; FBgn0265523; Smr. DR eggNOG; KOG1878; Eukaryota. DR eggNOG; ENOG410YDXP; LUCA. DR ChiTaRS; Smr; fly. DR Bgee; FBgn0265523; Expressed in eye disc (Drosophila) and 31 other tissues. DR ExpressionAtlas; Q9U4I2; baseline and differential. DR GO; GO:0005829; C:cytosol; HDA:FlyBase. DR GO; GO:0000118; C:histone deacetylase complex; IBA:GO_Central. DR GO; GO:0000790; C:nuclear chromatin; IBA:GO_Central. DR GO; GO:0005654; C:nucleoplasm; HDA:FlyBase. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0005700; C:polytene chromosome; NAS:FlyBase. DR GO; GO:0017053; C:transcriptional repressor complex; IPI:FlyBase. DR GO; GO:0003682; F:chromatin binding; IDA:FlyBase. DR GO; GO:0042826; F:histone deacetylase binding; IBA:GO_Central. DR GO; GO:0001012; F:RNA polymerase II regulatory region DNA binding; IBA:GO_Central. DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central. DR GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central. DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central. DR GO; GO:0030707; P:ovarian follicle cell development; IMP:FlyBase. DR GO; GO:0007346; P:regulation of mitotic cell cycle; IMP:FlyBase. DR CDD; cd00167; SANT; 1. DR InterPro; IPR009057; Homeobox-like_sf. DR InterPro; IPR031557; N-CoR_GPS2_interact. DR InterPro; IPR001005; SANT/Myb. DR InterPro; IPR017884; SANT_dom. DR Pfam; PF15784; GPS2_interact; 1. DR SMART; SM00717; SANT; 1. DR SUPFAM; SSF46689; SSF46689; 1. DR PROSITE; PS51293; SANT; 1. PE 2: Evidence at transcript level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Nucleus {ECO:0000256|SAAS:SAAS00160331}. FT DOMAIN 866..917 FT /note="SANT" FT /evidence="ECO:0000259|PROSITE:PS51293" FT REGION 56..81 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 110..145 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 160..218 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 259..296 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 311..353 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 396..475 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 494..527 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 543..568 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 920..946 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 958..990 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1037..1068 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1086..1141 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1171..1204 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1291..1319 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1365..1389 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1611..1834 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1854..1905 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1921..1979 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2027..2158 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2226..2287 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2335..2432 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2456..2653 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2693..2850 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2867..3005 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 3050..3140 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 3184..3209 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 3271..3324 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 3415..3437 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 596..637 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 747..767 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 110..128 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 203..218 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 259..279 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 311..338 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 396..410 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 419..475 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 932..946 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 971..990 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1086..1116 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1370..1389 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1612..1691 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1719..1736 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1861..1905 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1921..1954 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2027..2052 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2084..2105 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2125..2142 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2231..2245 FT /note="Pro-rich" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2262..2287 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2401..2416 FT /note="Pro-rich" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2456..2486 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2563..2577 FT /note="Pro-rich" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2600..2614 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2620..2643 FT /note="Pro-rich" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2703..2720 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2721..2789 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2932..2950 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2960..3005 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 3063..3102 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 3306..3322 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 3469 AA; 364116 MW; 6284E14C5C247CD9 CRC64; MAPKFFGCCK YFSLKVSFSP ASSMSAYQQR LPSNAASIHS PHWSYRALEQ QQQYAKQAAH LQQQQHQSHQ QQQQQQQDQR TNLHLQIHHH HQQQQQQQQQ QQQQQQQQQQ QQQQKQQQHH MQQQQQQQPL SPPHPPGSSS NSSSAAAAAA AAAAAAAAVN PGYPPSSAAA AAVNSGYPPR PPQHRFIQNT GYSIAPAPTY RDNPYSRHTQ IQQQQQQQQQ QQQQQQQQQQ QQQQQAAASM PEYQRAAARA AVAAVSAGKG NVSGQSSNSS SSSSGGGGGG GSAGGSAPPG GGVVQVSQSG GVLVMEAMPH YASQPNSNPS QQQQQQQQQQ QGGNPSGAGA TSGAGGGGGG SGGSVMVGSL GRILMPHPQA LQYTSEYLTN ATAAVAAAMV NQRQHLQLQQ QQQQQHPPEP FGGQQPYKKQ RLSEANANNM NHLPPHPQQQ HQQQQQQQQQ HQRSSPAQVQ QQQQQQMNSS RQSHNDMCRQ VVTTPMGMQL KVETLPQQQQ KQQQHQQQQQ QQQQGRSQPV VSSMSTVVSQ PVGTVTVTTA GLSASHSGSS GNVAAGLGTG NTGSASTEAY HPQVEAISPT LPSDSSIEER GRTSAKEDLL MQIQKVDNEI KSAETTMETL RKKEKSLMEE AALAKEQRAA KELNDNNNDQ EPMVELSWRS QMLAEKIYAA NRKTAQAQHS MLQNAAADES SPGSVAGRPW LPLYNQPLDV EALAMLIRQH QSQIRAPLLL HIRKLKAERW AHNQGLVEKY TKDQADWQRR CERMEASAKR KAREAKNREF FEKVFTELRK QREDKERFNR VGSRIKSEAD LEEIMDGLQE QALEDKKMRS YAVIPPLMHD ARQRRCAYHN ENGLIEDMVA VHQQRKALNM WTAGEKETFK EKYLQHPKNF GAIAASLDRK SPQDCVRYYY LSKKTENYKQ LLRKSRQRTR SSRNPAKAQA AQPQCIIDSM TTGVMTRLQR EQQQKSGGRS SAVAERERAE RAAERERVAE KAAADAAKAA ESAAEKASAA TKAVEATAAG EKVAKAAAAA AAAAATTATT ATTTTSSSTS SSSSSASSAS TASSSTASPA TLAGIAADKT DAGKTASASD KNAATAGGPT ATGTPTAATT PATATAPPEI SAGGEAKSKN AEEEAAATAG AATVATAGTP ATGASAASAG EATTATGATA TAAAKGVGKP ETATEPAGTA AKGADSRPDA NDPLAKTASK AINAEGYNAI GGNSSSSSSN ATGASAPVQG VTLNGFKPGY QTVVMANVKA STGGDDSGAN AGGAAPGSLA ATNASIATSG DKIVKTTPSS RAPNSTSSTA ANESSSGAGV NTYGHTATTA GNYLGQKLKA AQVEGLGAGN ELHSDVSESK RKRFELNSGE AGGNATSAMT NSSTSGSMNI SNSHGLKANA KDGSMMAKTS MASTSSASVV VTSTPSASSS SLSSASSMLL ISAASVMSTA AGATSSSTAT TTATASAISL PLLADGSGNS MVNANEILAL DGKDKLASCF VCKAEACPRT RPLKKGRGQQ YGIPDETIPA GARVCNSCQC KSVRSRYPNC PLPTCPNPKD RAQRLRNIPS RLFELAPEVR DPLMAEFQIP PHATRCCSAC LMRIRRKLDP QLNLTDGSSG GAGSGSGGDE TDVSTSSCDE REPGGSDTAS VESPENLQRH KSLTMVKQQQ QQQQQQQQQQ QQQQQQQQQQ LSQPQPPPPA PQQQKGSSGR GGDQGTPLII TPTRMSSKSG SGGAQTAGDN ERLLPPAAGQ APKKQKTSEE YDSSATETAD EENENSPANR QSPKVLFHGH GHGHGGHANN VAGLQPPVAN MGTGGGVQPG GAAGQQVNGP ISMRREAVNN VQDCVFSVIE RSLKHKGPQP KGGQGQQQGQ GQGQGQGQGQ TPGQSQSPSQ QQQQQQQQQS ANNLERKELT IVREYRQDPG ILKQQQQQQQ AGGAPPTSAA GSLPHGTSVQ KLTTRPAAVA PPPPAHPLTP TSIGCAGSNN GTSDSLATLS VVNSHMGMVG IGHPGPMAHA SSAGGIGVDK ATITPVVKSS SGSSKSGGGS ASSHSTATPP ETIIYNVPVA HPQRGIPPPS QHSVHPAHPS HTQHPAHPQH SSHGQHTQLQ VPEPEPQTLD LSIKKPPRDG HSPHTGAGGS SSSGSGSGGP SSSDRHHGPP PPTMSMKHIV RSGGMYRGDT VTVPSLAAPS SYLYPTRSVK SIGGGGVVPG VLPGVPGIAL YLQPVPVPVP ISISGQGQLP PKAGQPPPAQ PPSGRGVAKV PPKLSPQQAH HLHPSHGHSP SQQQQQQQQQ QQQQQQQAAA AQQQLLVKSG SIIHGTPANS AQQQIIVHAP ATAAAAPSSL FSPKFDGLVR QTTPEGVGSV GPGGASGSGK HGSITQGTPL HMPPHHLESK RPYESYYKSS QRHSPAQQPG GNQQLPPPPQ QSSPQAPPPQ GYGVGVSSPY ARSPFAGVVE QPQVLSTRQI VMHDYITSQQ MQGQQQQQQQ QQQQQRNMSR GSSASGGGGG GGSDKESPSP RNSVGSASGF AYGGDKESAP RGRPEYSSRA SPADHVNSTP SPHRTPPPQR QGVIQRHNTG SKPPSPAAPP PSRMHMPPYQ YAPSGHDALA SFVDVAVQQP QLPVPSQKDD KSPGPSTAPG QVPGSGPPLG PSPLPPHAVV GVAQPPPPTA HHDQRYRDLT LHHHHHTLVQ QQIAQQQHYR SLNVAAQVDM QRQMDQAKRV MRHQQHQVQQ QQQQQQQQQH NHALERDREM QERMRERDRE REREREREQR ERERERERER ERERERREQD RARRVVAEER EHDSRRMERM FAGNVVTGSG GAGGGGPSPG QFLRASVPET GPPRSIPDRE RESYYRQAHG GPAPEDTPGQ LSAQSLIDAI IKHEINRSND ATAGPGREFP RPSFVHAPLP PRGSGSGGGT GTRSSPANVL HPMYLRDLRQ PLDGGAGSML TAENNGKPSS SGSPSVINID LDQERISAAA AAVAQQQQQQ QAPPPSQSSQ SRSVHGQLRT PTSQSGGSAP SPQQIHTKSI TFGELTDSII TSDYGTNPHL RPPYMAYLQE TQSILPPDRW KQNRRMQQKA EEANDHSQQQ QQQQHQQQHH AQQQQQQQQQ HHAQQHHPQM PGTGSGSAPG GAGQGGGSGG PGSGGGGAGR ASTPGEDGRN IIRMPQAVSP RKFNHEMMLH HVMGTTGAGG EAGQFFLPSR VVLPEQRGTP SGGGGAPGAG GPGSGGGATT IEKYVKTRIA EVMRDDIGYG KNRTVEVRTE DEVTADMVAH SHAAVHAAHV AHAAHVAHAA AMELQHRSKE PPPPEISVSR KTPNQYEVVD ASGRRSAGSG SVSVSVSGAN SHHSPYHPPA AAYAPSTYAF PYSALNVPGA AGGLPPHQPL QLAHQAVAPP GAFAKAKAAH ALSELGAVGG GVSLVVGGGS GGIAGGPGGV SVGVGVPGGG GPGSGGGGGG GHNSSSSQAS AAVAAAVAAA ASESKPLLLS KYDALSDED //