ID Q9U4I2_DROME Unreviewed; 3469 AA. AC Q9U4I2; DT 01-MAY-2000, integrated into UniProtKB/TrEMBL. DT 01-MAY-2000, sequence version 1. DT 03-JUL-2019, entry version 121. DE SubName: Full=SANT domain protein SMRTER {ECO:0000313|EMBL:AAD52614.1}; GN Name=Smr {ECO:0000313|FlyBase:FBgn0265523}; GN Synonyms=Smrter {ECO:0000313|EMBL:AAD52614.1}; GN ORFNames=CG4013 {ECO:0000313|FlyBase:FBgn0265523}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAD52614.1}; RN [1] {ECO:0000313|EMBL:AAD52614.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=10488333; DOI=10.1016/S1097-2765(00)80365-2; RA Tsai C.C., Kao H.Y., Yao T.P., McKeown M., Evans R.M.; RT "SMRTER, a Drosophila nuclear receptor coregulator, reveals that EcR- RT mediated repression is critical for development."; RL Mol. Cell 4:175-186(1999). CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|SAAS:SAAS00548613}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF175223; AAD52614.1; -; mRNA. DR PeptideAtlas; Q9U4I2; -. DR PRIDE; Q9U4I2; -. DR FlyBase; FBgn0265523; Smr. DR eggNOG; KOG1878; Eukaryota. DR eggNOG; ENOG410YDXP; LUCA. DR ChiTaRS; Smr; fly. DR Bgee; FBgn0265523; Expressed in 32 organ(s), highest expression level in eye disc (Drosophila). DR GO; GO:0005829; C:cytosol; HDA:FlyBase. DR GO; GO:0000118; C:histone deacetylase complex; IBA:GO_Central. DR GO; GO:0000790; C:nuclear chromatin; IBA:GO_Central. DR GO; GO:0005654; C:nucleoplasm; HDA:FlyBase. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0005700; C:polytene chromosome; NAS:FlyBase. DR GO; GO:0017053; C:transcriptional repressor complex; IPI:FlyBase. DR GO; GO:0003682; F:chromatin binding; IDA:FlyBase. DR GO; GO:0042826; F:histone deacetylase binding; IBA:GO_Central. DR GO; GO:0001012; F:RNA polymerase II regulatory region DNA binding; IBA:GO_Central. DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central. DR GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central. DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central. DR GO; GO:0030707; P:ovarian follicle cell development; IMP:FlyBase. DR GO; GO:0007346; P:regulation of mitotic cell cycle; IMP:FlyBase. DR CDD; cd00167; SANT; 1. DR InterPro; IPR009057; Homeobox-like_sf. DR InterPro; IPR031557; N-CoR_GPS2_interact. DR InterPro; IPR001005; SANT/Myb. DR InterPro; IPR017884; SANT_dom. DR Pfam; PF15784; GPS2_interact; 1. DR SMART; SM00717; SANT; 1. DR SUPFAM; SSF46689; SSF46689; 1. DR PROSITE; PS51293; SANT; 1. PE 2: Evidence at transcript level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Nucleus {ECO:0000256|SAAS:SAAS00160331}. FT DOMAIN 866 917 SANT. {ECO:0000259|PROSITE:PS51293}. FT REGION 56 81 Disordered. {ECO:0000256|MobiDB-lite: FT Q9U4I2}. FT REGION 110 145 Disordered. {ECO:0000256|MobiDB-lite: FT Q9U4I2}. FT REGION 160 218 Disordered. {ECO:0000256|MobiDB-lite: FT Q9U4I2}. FT REGION 259 296 Disordered. {ECO:0000256|MobiDB-lite: FT Q9U4I2}. FT REGION 311 353 Disordered. {ECO:0000256|MobiDB-lite: FT Q9U4I2}. FT REGION 396 475 Disordered. {ECO:0000256|MobiDB-lite: FT Q9U4I2}. FT REGION 494 527 Disordered. {ECO:0000256|MobiDB-lite: FT Q9U4I2}. FT REGION 543 568 Disordered. {ECO:0000256|MobiDB-lite: FT Q9U4I2}. FT REGION 920 946 Disordered. {ECO:0000256|MobiDB-lite: FT Q9U4I2}. FT REGION 958 990 Disordered. {ECO:0000256|MobiDB-lite: FT Q9U4I2}. FT REGION 1037 1068 Disordered. {ECO:0000256|MobiDB-lite: FT Q9U4I2}. FT REGION 1086 1141 Disordered. {ECO:0000256|MobiDB-lite: FT Q9U4I2}. FT REGION 1171 1204 Disordered. {ECO:0000256|MobiDB-lite: FT Q9U4I2}. FT REGION 1291 1319 Disordered. {ECO:0000256|MobiDB-lite: FT Q9U4I2}. FT REGION 1365 1389 Disordered. {ECO:0000256|MobiDB-lite: FT Q9U4I2}. FT REGION 1611 1834 Disordered. {ECO:0000256|MobiDB-lite: FT Q9U4I2}. FT REGION 1854 1905 Disordered. {ECO:0000256|MobiDB-lite: FT Q9U4I2}. FT REGION 1921 1979 Disordered. {ECO:0000256|MobiDB-lite: FT Q9U4I2}. FT REGION 2027 2158 Disordered. {ECO:0000256|MobiDB-lite: FT Q9U4I2}. FT REGION 2226 2287 Disordered. {ECO:0000256|MobiDB-lite: FT Q9U4I2}. FT REGION 2335 2432 Disordered. {ECO:0000256|MobiDB-lite: FT Q9U4I2}. FT REGION 2456 2653 Disordered. {ECO:0000256|MobiDB-lite: FT Q9U4I2}. FT REGION 2693 2850 Disordered. {ECO:0000256|MobiDB-lite: FT Q9U4I2}. FT REGION 2867 3005 Disordered. {ECO:0000256|MobiDB-lite: FT Q9U4I2}. FT REGION 3050 3140 Disordered. {ECO:0000256|MobiDB-lite: FT Q9U4I2}. FT REGION 3184 3209 Disordered. {ECO:0000256|MobiDB-lite: FT Q9U4I2}. FT REGION 3271 3324 Disordered. {ECO:0000256|MobiDB-lite: FT Q9U4I2}. FT REGION 3415 3437 Disordered. {ECO:0000256|MobiDB-lite: FT Q9U4I2}. FT COILED 596 637 {ECO:0000256|SAM:Coils}. FT COILED 747 767 {ECO:0000256|SAM:Coils}. FT COMPBIAS 110 128 Polar. {ECO:0000256|MobiDB-lite:Q9U4I2}. FT COMPBIAS 203 218 Polar. {ECO:0000256|MobiDB-lite:Q9U4I2}. FT COMPBIAS 259 279 Polar. {ECO:0000256|MobiDB-lite:Q9U4I2}. FT COMPBIAS 311 338 Polar. {ECO:0000256|MobiDB-lite:Q9U4I2}. FT COMPBIAS 396 410 Polar. {ECO:0000256|MobiDB-lite:Q9U4I2}. FT COMPBIAS 419 475 Polar. {ECO:0000256|MobiDB-lite:Q9U4I2}. FT COMPBIAS 932 946 Polar. {ECO:0000256|MobiDB-lite:Q9U4I2}. FT COMPBIAS 971 990 Polyampholyte. {ECO:0000256|MobiDB-lite: FT Q9U4I2}. FT COMPBIAS 1086 1116 Polar. {ECO:0000256|MobiDB-lite:Q9U4I2}. FT COMPBIAS 1370 1389 Polar. {ECO:0000256|MobiDB-lite:Q9U4I2}. FT COMPBIAS 1612 1691 Polar. {ECO:0000256|MobiDB-lite:Q9U4I2}. FT COMPBIAS 1719 1736 Polar. {ECO:0000256|MobiDB-lite:Q9U4I2}. FT COMPBIAS 1861 1905 Polar. {ECO:0000256|MobiDB-lite:Q9U4I2}. FT COMPBIAS 1921 1954 Polar. {ECO:0000256|MobiDB-lite:Q9U4I2}. FT COMPBIAS 2027 2052 Polar. {ECO:0000256|MobiDB-lite:Q9U4I2}. FT COMPBIAS 2084 2105 Polar. {ECO:0000256|MobiDB-lite:Q9U4I2}. FT COMPBIAS 2125 2142 Polar. {ECO:0000256|MobiDB-lite:Q9U4I2}. FT COMPBIAS 2231 2245 Pro-rich. {ECO:0000256|MobiDB-lite: FT Q9U4I2}. FT COMPBIAS 2262 2287 Polar. {ECO:0000256|MobiDB-lite:Q9U4I2}. FT COMPBIAS 2401 2416 Pro-rich. {ECO:0000256|MobiDB-lite: FT Q9U4I2}. FT COMPBIAS 2456 2486 Polar. {ECO:0000256|MobiDB-lite:Q9U4I2}. FT COMPBIAS 2563 2577 Pro-rich. {ECO:0000256|MobiDB-lite: FT Q9U4I2}. FT COMPBIAS 2600 2614 Polar. {ECO:0000256|MobiDB-lite:Q9U4I2}. FT COMPBIAS 2620 2643 Pro-rich. {ECO:0000256|MobiDB-lite: FT Q9U4I2}. FT COMPBIAS 2703 2720 Polar. {ECO:0000256|MobiDB-lite:Q9U4I2}. FT COMPBIAS 2721 2789 Polyampholyte. {ECO:0000256|MobiDB-lite: FT Q9U4I2}. FT COMPBIAS 2932 2950 Polar. {ECO:0000256|MobiDB-lite:Q9U4I2}. FT COMPBIAS 2960 3005 Polar. {ECO:0000256|MobiDB-lite:Q9U4I2}. FT COMPBIAS 3063 3102 Polar. {ECO:0000256|MobiDB-lite:Q9U4I2}. FT COMPBIAS 3306 3322 Polar. {ECO:0000256|MobiDB-lite:Q9U4I2}. SQ SEQUENCE 3469 AA; 364116 MW; 6284E14C5C247CD9 CRC64; MAPKFFGCCK YFSLKVSFSP ASSMSAYQQR LPSNAASIHS PHWSYRALEQ QQQYAKQAAH LQQQQHQSHQ QQQQQQQDQR TNLHLQIHHH HQQQQQQQQQ QQQQQQQQQQ QQQQKQQQHH MQQQQQQQPL SPPHPPGSSS NSSSAAAAAA AAAAAAAAVN PGYPPSSAAA AAVNSGYPPR PPQHRFIQNT GYSIAPAPTY RDNPYSRHTQ IQQQQQQQQQ QQQQQQQQQQ QQQQQAAASM PEYQRAAARA AVAAVSAGKG NVSGQSSNSS SSSSGGGGGG GSAGGSAPPG GGVVQVSQSG GVLVMEAMPH YASQPNSNPS QQQQQQQQQQ QGGNPSGAGA TSGAGGGGGG SGGSVMVGSL GRILMPHPQA LQYTSEYLTN ATAAVAAAMV NQRQHLQLQQ QQQQQHPPEP FGGQQPYKKQ RLSEANANNM NHLPPHPQQQ HQQQQQQQQQ HQRSSPAQVQ QQQQQQMNSS RQSHNDMCRQ VVTTPMGMQL KVETLPQQQQ KQQQHQQQQQ QQQQGRSQPV VSSMSTVVSQ PVGTVTVTTA GLSASHSGSS GNVAAGLGTG NTGSASTEAY HPQVEAISPT LPSDSSIEER GRTSAKEDLL MQIQKVDNEI KSAETTMETL RKKEKSLMEE AALAKEQRAA KELNDNNNDQ EPMVELSWRS QMLAEKIYAA NRKTAQAQHS MLQNAAADES SPGSVAGRPW LPLYNQPLDV EALAMLIRQH QSQIRAPLLL HIRKLKAERW AHNQGLVEKY TKDQADWQRR CERMEASAKR KAREAKNREF FEKVFTELRK QREDKERFNR VGSRIKSEAD LEEIMDGLQE QALEDKKMRS YAVIPPLMHD ARQRRCAYHN ENGLIEDMVA VHQQRKALNM WTAGEKETFK EKYLQHPKNF GAIAASLDRK SPQDCVRYYY LSKKTENYKQ LLRKSRQRTR SSRNPAKAQA AQPQCIIDSM TTGVMTRLQR EQQQKSGGRS SAVAERERAE RAAERERVAE KAAADAAKAA ESAAEKASAA TKAVEATAAG EKVAKAAAAA AAAAATTATT ATTTTSSSTS SSSSSASSAS TASSSTASPA TLAGIAADKT DAGKTASASD KNAATAGGPT ATGTPTAATT PATATAPPEI SAGGEAKSKN AEEEAAATAG AATVATAGTP ATGASAASAG EATTATGATA TAAAKGVGKP ETATEPAGTA AKGADSRPDA NDPLAKTASK AINAEGYNAI GGNSSSSSSN ATGASAPVQG VTLNGFKPGY QTVVMANVKA STGGDDSGAN AGGAAPGSLA ATNASIATSG DKIVKTTPSS RAPNSTSSTA ANESSSGAGV NTYGHTATTA GNYLGQKLKA AQVEGLGAGN ELHSDVSESK RKRFELNSGE AGGNATSAMT NSSTSGSMNI SNSHGLKANA KDGSMMAKTS MASTSSASVV VTSTPSASSS SLSSASSMLL ISAASVMSTA AGATSSSTAT TTATASAISL PLLADGSGNS MVNANEILAL DGKDKLASCF VCKAEACPRT RPLKKGRGQQ YGIPDETIPA GARVCNSCQC KSVRSRYPNC PLPTCPNPKD RAQRLRNIPS RLFELAPEVR DPLMAEFQIP PHATRCCSAC LMRIRRKLDP QLNLTDGSSG GAGSGSGGDE TDVSTSSCDE REPGGSDTAS VESPENLQRH KSLTMVKQQQ QQQQQQQQQQ QQQQQQQQQQ LSQPQPPPPA PQQQKGSSGR GGDQGTPLII TPTRMSSKSG SGGAQTAGDN ERLLPPAAGQ APKKQKTSEE YDSSATETAD EENENSPANR QSPKVLFHGH GHGHGGHANN VAGLQPPVAN MGTGGGVQPG GAAGQQVNGP ISMRREAVNN VQDCVFSVIE RSLKHKGPQP KGGQGQQQGQ GQGQGQGQGQ TPGQSQSPSQ QQQQQQQQQS ANNLERKELT IVREYRQDPG ILKQQQQQQQ AGGAPPTSAA GSLPHGTSVQ KLTTRPAAVA PPPPAHPLTP TSIGCAGSNN GTSDSLATLS VVNSHMGMVG IGHPGPMAHA SSAGGIGVDK ATITPVVKSS SGSSKSGGGS ASSHSTATPP ETIIYNVPVA HPQRGIPPPS QHSVHPAHPS HTQHPAHPQH SSHGQHTQLQ VPEPEPQTLD LSIKKPPRDG HSPHTGAGGS SSSGSGSGGP SSSDRHHGPP PPTMSMKHIV RSGGMYRGDT VTVPSLAAPS SYLYPTRSVK SIGGGGVVPG VLPGVPGIAL YLQPVPVPVP ISISGQGQLP PKAGQPPPAQ PPSGRGVAKV PPKLSPQQAH HLHPSHGHSP SQQQQQQQQQ QQQQQQQAAA AQQQLLVKSG SIIHGTPANS AQQQIIVHAP ATAAAAPSSL FSPKFDGLVR QTTPEGVGSV GPGGASGSGK HGSITQGTPL HMPPHHLESK RPYESYYKSS QRHSPAQQPG GNQQLPPPPQ QSSPQAPPPQ GYGVGVSSPY ARSPFAGVVE QPQVLSTRQI VMHDYITSQQ MQGQQQQQQQ QQQQQRNMSR GSSASGGGGG GGSDKESPSP RNSVGSASGF AYGGDKESAP RGRPEYSSRA SPADHVNSTP SPHRTPPPQR QGVIQRHNTG SKPPSPAAPP PSRMHMPPYQ YAPSGHDALA SFVDVAVQQP QLPVPSQKDD KSPGPSTAPG QVPGSGPPLG PSPLPPHAVV GVAQPPPPTA HHDQRYRDLT LHHHHHTLVQ QQIAQQQHYR SLNVAAQVDM QRQMDQAKRV MRHQQHQVQQ QQQQQQQQQH NHALERDREM QERMRERDRE REREREREQR ERERERERER ERERERREQD RARRVVAEER EHDSRRMERM FAGNVVTGSG GAGGGGPSPG QFLRASVPET GPPRSIPDRE RESYYRQAHG GPAPEDTPGQ LSAQSLIDAI IKHEINRSND ATAGPGREFP RPSFVHAPLP PRGSGSGGGT GTRSSPANVL HPMYLRDLRQ PLDGGAGSML TAENNGKPSS SGSPSVINID LDQERISAAA AAVAQQQQQQ QAPPPSQSSQ SRSVHGQLRT PTSQSGGSAP SPQQIHTKSI TFGELTDSII TSDYGTNPHL RPPYMAYLQE TQSILPPDRW KQNRRMQQKA EEANDHSQQQ QQQQHQQQHH AQQQQQQQQQ HHAQQHHPQM PGTGSGSAPG GAGQGGGSGG PGSGGGGAGR ASTPGEDGRN IIRMPQAVSP RKFNHEMMLH HVMGTTGAGG EAGQFFLPSR VVLPEQRGTP SGGGGAPGAG GPGSGGGATT IEKYVKTRIA EVMRDDIGYG KNRTVEVRTE DEVTADMVAH SHAAVHAAHV AHAAHVAHAA AMELQHRSKE PPPPEISVSR KTPNQYEVVD ASGRRSAGSG SVSVSVSGAN SHHSPYHPPA AAYAPSTYAF PYSALNVPGA AGGLPPHQPL QLAHQAVAPP GAFAKAKAAH ALSELGAVGG GVSLVVGGGS GGIAGGPGGV SVGVGVPGGG GPGSGGGGGG GHNSSSSQAS AAVAAAVAAA ASESKPLLLS KYDALSDED //