ID Q9U4I2_DROME Unreviewed; 3469 AA. AC Q9U4I2; DT 01-MAY-2000, integrated into UniProtKB/TrEMBL. DT 01-MAY-2000, sequence version 1. DT 07-JUN-2017, entry version 105. DE SubName: Full=SANT domain protein SMRTER {ECO:0000313|EMBL:AAD52614.1}; GN Name=Smr {ECO:0000313|FlyBase:FBgn0265523}; GN Synonyms=Smrter {ECO:0000313|EMBL:AAD52614.1}; GN ORFNames=CG4013 {ECO:0000313|FlyBase:FBgn0265523}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAD52614.1}; RN [1] {ECO:0000313|EMBL:AAD52614.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=10488333; DOI=10.1016/S1097-2765(00)80365-2; RA Tsai C.C., Kao H.Y., Yao T.P., McKeown M., Evans R.M.; RT "SMRTER, a Drosophila nuclear receptor coregulator, reveals that EcR- RT mediated repression is critical for development."; RL Mol. Cell 4:175-186(1999). CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|SAAS:SAAS00548613}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF175223; AAD52614.1; -; mRNA. DR ProteinModelPortal; Q9U4I2; -. DR STRING; 7227.FBpp0305909; -. DR PaxDb; Q9U4I2; -. DR PeptideAtlas; Q9U4I2; -. DR PRIDE; Q9U4I2; -. DR FlyBase; FBgn0265523; Smr. DR eggNOG; KOG1878; Eukaryota. DR eggNOG; ENOG410YDXP; LUCA. DR OrthoDB; EOG091G007Q; -. DR Reactome; R-DME-2173795; Downregulation of SMAD2/3:SMAD4 transcriptional activity. DR Reactome; R-DME-3214815; HDACs deacetylate histones. DR ChiTaRS; Smr; fly. DR Bgee; FBgn0263865; -. DR ExpressionAtlas; Q9U4I2; differential. DR GO; GO:0005829; C:cytosol; IDA:FlyBase. DR GO; GO:0005654; C:nucleoplasm; IDA:FlyBase. DR GO; GO:0005700; C:polytene chromosome; IDA:FlyBase. DR GO; GO:0017053; C:transcriptional repressor complex; IPI:FlyBase. DR GO; GO:0003682; F:chromatin binding; IDA:FlyBase. DR GO; GO:0003677; F:DNA binding; IEA:InterPro. DR GO; GO:0003714; F:transcription corepressor activity; TAS:FlyBase. DR GO; GO:0007476; P:imaginal disc-derived wing morphogenesis; IMP:FlyBase. DR GO; GO:0045746; P:negative regulation of Notch signaling pathway; IMP:FlyBase. DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; TAS:FlyBase. DR GO; GO:0030707; P:ovarian follicle cell development; IMP:FlyBase. DR GO; GO:0006909; P:phagocytosis; IMP:FlyBase. DR GO; GO:0010906; P:regulation of glucose metabolic process; IMP:FlyBase. DR GO; GO:0007346; P:regulation of mitotic cell cycle; IMP:FlyBase. DR Gene3D; 2.130.10.10; -; 3. DR InterPro; IPR009057; Homeobox-like. DR InterPro; IPR001005; SANT/Myb. DR InterPro; IPR017884; SANT_dom. DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom. DR SMART; SM00717; SANT; 1. DR SUPFAM; SSF46689; SSF46689; 1. DR PROSITE; PS51293; SANT; 1. PE 2: Evidence at transcript level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Nucleus {ECO:0000256|SAAS:SAAS00501360}. FT DOMAIN 866 917 SANT. {ECO:0000259|PROSITE:PS51293}. FT COILED 90 118 {ECO:0000256|SAM:Coils}. FT COILED 208 235 {ECO:0000256|SAM:Coils}. FT COILED 596 637 {ECO:0000256|SAM:Coils}. FT COILED 1663 1690 {ECO:0000256|SAM:Coils}. FT COILED 2721 2767 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 3469 AA; 364116 MW; 6284E14C5C247CD9 CRC64; MAPKFFGCCK YFSLKVSFSP ASSMSAYQQR LPSNAASIHS PHWSYRALEQ QQQYAKQAAH LQQQQHQSHQ QQQQQQQDQR TNLHLQIHHH HQQQQQQQQQ QQQQQQQQQQ QQQQKQQQHH MQQQQQQQPL SPPHPPGSSS NSSSAAAAAA AAAAAAAAVN PGYPPSSAAA AAVNSGYPPR PPQHRFIQNT GYSIAPAPTY RDNPYSRHTQ IQQQQQQQQQ QQQQQQQQQQ QQQQQAAASM PEYQRAAARA AVAAVSAGKG NVSGQSSNSS SSSSGGGGGG GSAGGSAPPG GGVVQVSQSG GVLVMEAMPH YASQPNSNPS QQQQQQQQQQ QGGNPSGAGA TSGAGGGGGG SGGSVMVGSL GRILMPHPQA LQYTSEYLTN ATAAVAAAMV NQRQHLQLQQ QQQQQHPPEP FGGQQPYKKQ RLSEANANNM NHLPPHPQQQ HQQQQQQQQQ HQRSSPAQVQ QQQQQQMNSS RQSHNDMCRQ VVTTPMGMQL KVETLPQQQQ KQQQHQQQQQ QQQQGRSQPV VSSMSTVVSQ PVGTVTVTTA GLSASHSGSS GNVAAGLGTG NTGSASTEAY HPQVEAISPT LPSDSSIEER GRTSAKEDLL MQIQKVDNEI KSAETTMETL RKKEKSLMEE AALAKEQRAA KELNDNNNDQ EPMVELSWRS QMLAEKIYAA NRKTAQAQHS MLQNAAADES SPGSVAGRPW LPLYNQPLDV EALAMLIRQH QSQIRAPLLL HIRKLKAERW AHNQGLVEKY TKDQADWQRR CERMEASAKR KAREAKNREF FEKVFTELRK QREDKERFNR VGSRIKSEAD LEEIMDGLQE QALEDKKMRS YAVIPPLMHD ARQRRCAYHN ENGLIEDMVA VHQQRKALNM WTAGEKETFK EKYLQHPKNF GAIAASLDRK SPQDCVRYYY LSKKTENYKQ LLRKSRQRTR SSRNPAKAQA AQPQCIIDSM TTGVMTRLQR EQQQKSGGRS SAVAERERAE RAAERERVAE KAAADAAKAA ESAAEKASAA TKAVEATAAG EKVAKAAAAA AAAAATTATT ATTTTSSSTS SSSSSASSAS TASSSTASPA TLAGIAADKT DAGKTASASD KNAATAGGPT ATGTPTAATT PATATAPPEI SAGGEAKSKN AEEEAAATAG AATVATAGTP ATGASAASAG EATTATGATA TAAAKGVGKP ETATEPAGTA AKGADSRPDA NDPLAKTASK AINAEGYNAI GGNSSSSSSN ATGASAPVQG VTLNGFKPGY QTVVMANVKA STGGDDSGAN AGGAAPGSLA ATNASIATSG DKIVKTTPSS RAPNSTSSTA ANESSSGAGV NTYGHTATTA GNYLGQKLKA AQVEGLGAGN ELHSDVSESK RKRFELNSGE AGGNATSAMT NSSTSGSMNI SNSHGLKANA KDGSMMAKTS MASTSSASVV VTSTPSASSS SLSSASSMLL ISAASVMSTA AGATSSSTAT TTATASAISL PLLADGSGNS MVNANEILAL DGKDKLASCF VCKAEACPRT RPLKKGRGQQ YGIPDETIPA GARVCNSCQC KSVRSRYPNC PLPTCPNPKD RAQRLRNIPS RLFELAPEVR DPLMAEFQIP PHATRCCSAC LMRIRRKLDP QLNLTDGSSG GAGSGSGGDE TDVSTSSCDE REPGGSDTAS VESPENLQRH KSLTMVKQQQ QQQQQQQQQQ QQQQQQQQQQ LSQPQPPPPA PQQQKGSSGR GGDQGTPLII TPTRMSSKSG SGGAQTAGDN ERLLPPAAGQ APKKQKTSEE YDSSATETAD EENENSPANR QSPKVLFHGH GHGHGGHANN VAGLQPPVAN MGTGGGVQPG GAAGQQVNGP ISMRREAVNN VQDCVFSVIE RSLKHKGPQP KGGQGQQQGQ GQGQGQGQGQ TPGQSQSPSQ QQQQQQQQQS ANNLERKELT IVREYRQDPG ILKQQQQQQQ AGGAPPTSAA GSLPHGTSVQ KLTTRPAAVA PPPPAHPLTP TSIGCAGSNN GTSDSLATLS VVNSHMGMVG IGHPGPMAHA SSAGGIGVDK ATITPVVKSS SGSSKSGGGS ASSHSTATPP ETIIYNVPVA HPQRGIPPPS QHSVHPAHPS HTQHPAHPQH SSHGQHTQLQ VPEPEPQTLD LSIKKPPRDG HSPHTGAGGS SSSGSGSGGP SSSDRHHGPP PPTMSMKHIV RSGGMYRGDT VTVPSLAAPS SYLYPTRSVK SIGGGGVVPG VLPGVPGIAL YLQPVPVPVP ISISGQGQLP PKAGQPPPAQ PPSGRGVAKV PPKLSPQQAH HLHPSHGHSP SQQQQQQQQQ QQQQQQQAAA AQQQLLVKSG SIIHGTPANS AQQQIIVHAP ATAAAAPSSL FSPKFDGLVR QTTPEGVGSV GPGGASGSGK HGSITQGTPL HMPPHHLESK RPYESYYKSS QRHSPAQQPG GNQQLPPPPQ QSSPQAPPPQ GYGVGVSSPY ARSPFAGVVE QPQVLSTRQI VMHDYITSQQ MQGQQQQQQQ QQQQQRNMSR GSSASGGGGG GGSDKESPSP RNSVGSASGF AYGGDKESAP RGRPEYSSRA SPADHVNSTP SPHRTPPPQR QGVIQRHNTG SKPPSPAAPP PSRMHMPPYQ YAPSGHDALA SFVDVAVQQP QLPVPSQKDD KSPGPSTAPG QVPGSGPPLG PSPLPPHAVV GVAQPPPPTA HHDQRYRDLT LHHHHHTLVQ QQIAQQQHYR SLNVAAQVDM QRQMDQAKRV MRHQQHQVQQ QQQQQQQQQH NHALERDREM QERMRERDRE REREREREQR ERERERERER ERERERREQD RARRVVAEER EHDSRRMERM FAGNVVTGSG GAGGGGPSPG QFLRASVPET GPPRSIPDRE RESYYRQAHG GPAPEDTPGQ LSAQSLIDAI IKHEINRSND ATAGPGREFP RPSFVHAPLP PRGSGSGGGT GTRSSPANVL HPMYLRDLRQ PLDGGAGSML TAENNGKPSS SGSPSVINID LDQERISAAA AAVAQQQQQQ QAPPPSQSSQ SRSVHGQLRT PTSQSGGSAP SPQQIHTKSI TFGELTDSII TSDYGTNPHL RPPYMAYLQE TQSILPPDRW KQNRRMQQKA EEANDHSQQQ QQQQHQQQHH AQQQQQQQQQ HHAQQHHPQM PGTGSGSAPG GAGQGGGSGG PGSGGGGAGR ASTPGEDGRN IIRMPQAVSP RKFNHEMMLH HVMGTTGAGG EAGQFFLPSR VVLPEQRGTP SGGGGAPGAG GPGSGGGATT IEKYVKTRIA EVMRDDIGYG KNRTVEVRTE DEVTADMVAH SHAAVHAAHV AHAAHVAHAA AMELQHRSKE PPPPEISVSR KTPNQYEVVD ASGRRSAGSG SVSVSVSGAN SHHSPYHPPA AAYAPSTYAF PYSALNVPGA AGGLPPHQPL QLAHQAVAPP GAFAKAKAAH ALSELGAVGG GVSLVVGGGS GGIAGGPGGV SVGVGVPGGG GPGSGGGGGG GHNSSSSQAS AAVAAAVAAA ASESKPLLLS KYDALSDED //