ID   Q9U1L3_DROME            Unreviewed;       368 AA.
AC   Q9U1L3;
DT   01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2000, sequence version 1.
DT   10-MAY-2017, entry version 82.
DE   RecName: Full=Translocating chain-associated membrane protein {ECO:0000256|PIRNR:PIRNR005449};
GN   Name=TRAM {ECO:0000313|FlyBase:FBgn0040340};
GN   Synonyms=EG:BACR7A4.5 {ECO:0000313|EMBL:CAB65875.1};
GN   ORFNames=CG11642 {ECO:0000313|FlyBase:FBgn0040340};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1] {ECO:0000313|EMBL:CAB65875.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Papagiannakis G., Spanos L., Bolshakov V., Siden-Kiamos I., Louis C.;
RT   "Sequencing the distal X chromosome of Drosophila melanogaster.";
RL   Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CAB65875.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Benos P.;
RL   Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the TRAM family.
CC       {ECO:0000256|PIRNR:PIRNR005449}.
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DR   EMBL; AL109630; CAB65875.1; -; Genomic_DNA.
DR   IntAct; Q9U1L3; 1.
DR   STRING; 7227.FBpp0070162; -.
DR   PaxDb; Q9U1L3; -.
DR   PRIDE; Q9U1L3; -.
DR   FlyBase; FBgn0040340; TRAM.
DR   eggNOG; KOG1608; Eukaryota.
DR   eggNOG; ENOG410XSB3; LUCA.
DR   OrthoDB; EOG091G077N; -.
DR   Bgee; FBgn0040340; -.
DR   ExpressionAtlas; Q9U1L3; differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005811; C:lipid particle; IDA:FlyBase.
DR   GO; GO:0006909; P:phagocytosis; IMP:FlyBase.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR006634; TLC-dom.
DR   InterPro; IPR013599; TRAM1.
DR   InterPro; IPR016447; Translocation_assoc_membrane.
DR   Pfam; PF08390; TRAM1; 1.
DR   Pfam; PF03798; TRAM_LAG1_CLN8; 1.
DR   PIRSF; PIRSF005449; Translocation_assoc_membrane; 1.
DR   SMART; SM00724; TLC; 1.
DR   PROSITE; PS50922; TLC; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Membrane {ECO:0000256|SAAS:SAAS00075723, ECO:0000256|SAM:Phobius};
KW   Protein transport {ECO:0000256|PIRNR:PIRNR005449};
KW   Translocation {ECO:0000256|PIRNR:PIRNR005449};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00075724,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00075722,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|PIRNR:PIRNR005449}.
FT   TRANSMEM     31     56       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     89    108       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    129    147       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    204    221       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    227    249       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    261    285       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    291    310       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      123    318       TLC (TRAM/LAG1/CLN8).
FT                                {ECO:0000259|PROSITE:PS50922}.
FT   COILED      306    333       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   368 AA;  41766 MW;  693795FFFC2ED4A6 CRC64;
     MAIKPGLGRK TSNKNPPILS HEFVIQNHAD IISCVAMVFV VGLMNESTAA FASAFISLHH
     NVSGEDPSRE QPYGKPYTYI AGIKDYCAIF FYTLTCIIMH AIIQEFVLDN ISKKLHLSKF
     KLARFNESGQ LVAFYLLSFV WGAHVLLKEG YLGQVAQLWE GFPDHPMSFL HKFYFVVQLA
     YYLHMLPELY FQKIKTKEEQ QPKIVHSISG FTLIVLAYTL SFQRLALVLL TLHYFSELLS
     HVFQLIGVFD REERLAKLRV VNNAVFFLIR FATSVIGVLT LYYGIGGVRS LLALGGLIAL
     QGYLVFSFIT EQLRAKREAK KEAKREAKLA LQTKKPAKTP KDKVKRKKES DLPEADQTSP
     SPIKQKLK
//