ID Q9TZQ2_DROME Unreviewed; 484 AA. AC Q9TZQ2; DT 01-MAY-2000, integrated into UniProtKB/TrEMBL. DT 01-MAY-2000, sequence version 1. DT 14-DEC-2022, entry version 139. DE RecName: Full=Mothers against decapentaplegic homolog {ECO:0000256|RuleBase:RU361195}; DE Short=MAD homolog {ECO:0000256|RuleBase:RU361195}; DE Short=Mothers against DPP homolog {ECO:0000256|RuleBase:RU361195}; DE AltName: Full=SMAD family member {ECO:0000256|RuleBase:RU361195}; GN Name=Smox {ECO:0000313|EMBL:AAC83344.1, GN ECO:0000313|FlyBase:FBgn0025800}; GN ORFNames=CG2262 {ECO:0000313|FlyBase:FBgn0025800}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAC83344.1}; RN [1] {ECO:0000313|EMBL:AAC83344.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=9813169; DOI=10.1006/bbrc.1998.9562; RA Henderson K.D., Andrew D.J.; RT "Identification of a novel Drosophila SMAD on the X chromosome."; RL Biochem. Biophys. Res. Commun. 252:195-201(1998). CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU361195}. CC Nucleus {ECO:0000256|RuleBase:RU361195}. CC -!- SIMILARITY: Belongs to the dwarfin/SMAD family. CC {ECO:0000256|ARBA:ARBA00005545, ECO:0000256|RuleBase:RU361195}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF078529; AAC83344.1; -; mRNA. DR PIR; JE0341; JE0341. DR AlphaFoldDB; Q9TZQ2; -. DR IntAct; Q9TZQ2; 1. DR AGR; FB:FBgn0025800; -. DR FlyBase; FBgn0025800; Smox. DR VEuPathDB; VectorBase:FBgn0025800; -. DR HOGENOM; CLU_026736_0_2_1; -. DR ExpressionAtlas; Q9TZQ2; baseline and differential. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0071144; C:heteromeric SMAD protein complex; IBA:GO_Central. DR GO; GO:0031490; F:chromatin DNA binding; IDA:FlyBase. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central. DR GO; GO:0070411; F:I-SMAD binding; IBA:GO_Central. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central. DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central. DR GO; GO:0030509; P:BMP signaling pathway; IBA:GO_Central. DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central. DR GO; GO:0048813; P:dendrite morphogenesis; NAS:FlyBase. DR GO; GO:0008340; P:determination of adult lifespan; IMP:FlyBase. DR GO; GO:0007476; P:imaginal disc-derived wing morphogenesis; IMP:FlyBase. DR GO; GO:0010507; P:negative regulation of autophagy; IMP:FlyBase. DR GO; GO:0048666; P:neuron development; IMP:FlyBase. DR GO; GO:0090256; P:regulation of cell proliferation involved in imaginal disc-derived wing morphogenesis; IMP:FlyBase. DR GO; GO:0060395; P:SMAD protein signal transduction; IBA:GO_Central. DR Gene3D; 2.60.200.10; -; 1. DR Gene3D; 3.90.520.10; -; 1. DR InterPro; IPR013790; Dwarfin. DR InterPro; IPR003619; MAD_homology1_Dwarfin-type. DR InterPro; IPR013019; MAD_homology_MH1. DR InterPro; IPR017855; SMAD-like_dom_sf. DR InterPro; IPR001132; SMAD_dom_Dwarfin-type. DR InterPro; IPR008984; SMAD_FHA_dom_sf. DR InterPro; IPR036578; SMAD_MH1_sf. DR PANTHER; PTHR13703; SMAD; 2. DR Pfam; PF03165; MH1; 1. DR Pfam; PF03166; MH2; 1. DR SMART; SM00523; DWA; 1. DR SMART; SM00524; DWB; 1. DR SUPFAM; SSF56366; SMAD MH1 domain; 1. DR SUPFAM; SSF49879; SMAD/FHA domain; 1. DR PROSITE; PS51075; MH1; 1. DR PROSITE; PS51076; MH2; 1. PE 2: Evidence at transcript level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Cytoplasm {ECO:0000256|RuleBase:RU361195}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU361195}; KW Transcription {ECO:0000256|ARBA:ARBA00023163, KW ECO:0000256|RuleBase:RU361195}; KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, KW ECO:0000256|RuleBase:RU361195}; Zinc {ECO:0000256|ARBA:ARBA00022833}. FT DOMAIN 7..132 FT /note="MH1" FT /evidence="ECO:0000259|PROSITE:PS51075" FT DOMAIN 291..484 FT /note="MH2" FT /evidence="ECO:0000259|PROSITE:PS51076" FT REGION 182..275 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 30..57 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 185..251 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 484 AA; 53475 MW; 9558C5C61A8EC812 CRC64; MLPFTPQVVK RLLALKKGNE DNSVEGKWSE KAVKNLVKKI KKQLEELERA ISTQNCQTRC VTVPRSKPAP AGEHLRKGLP HVIYCRLWRW PDLQSQNELK PLDHCEYAFH LRKEEICINP YHYKKIELSI LVPKSLPTPP DSIVDYPLDN HTHQIPNNTD YNAAIIRSAS LSPPQYMELG GAGPVSVSSS ASSTPATAAG GGGGPSSSSS SSSSAASAYQ QQQQQLSFGQ NMDSQSSVLS VGSSIPNTGT PPPGYMSEDG DPIDPNDNMN MSRLTPPADA APVMYHEPAF WCSISYYELN TRVGETFHAS QPSITVDGFT DPSNSERFCL GLLSNVNRNE VVEQTRRHIG KGVRLYYIGG EVFAECLSDS SIFVQSPNCN QRYGWHPATV CKIPPGCNLK IFNNQEFAAL LSQSVSQGFE AVYQLTRMCT IRMSFVKGWG AEYRRQTVTS TPCWIELHLN GPLQWLDRVL TQMGSPRLPC SSMS //