ID Q9TZQ2_DROME Unreviewed; 484 AA. AC Q9TZQ2; DT 01-MAY-2000, integrated into UniProtKB/TrEMBL. DT 01-MAY-2000, sequence version 1. DT 17-FEB-2016, entry version 101. DE RecName: Full=Mothers against decapentaplegic homolog {ECO:0000256|RuleBase:RU361195}; DE Short=MAD homolog {ECO:0000256|RuleBase:RU361195}; DE Short=Mothers against DPP homolog {ECO:0000256|RuleBase:RU361195}; DE AltName: Full=SMAD family member {ECO:0000256|RuleBase:RU361195}; GN Name=Smox {ECO:0000313|EMBL:AAC83344.1, GN ECO:0000313|FlyBase:FBgn0025800}; GN ORFNames=CG2262 {ECO:0000313|FlyBase:FBgn0025800}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAC83344.1}; RN [1] {ECO:0000313|EMBL:AAC83344.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=9813169; DOI=10.1006/bbrc.1998.9562; RA Henderson K.D., Andrew D.J.; RT "Identification of a novel Drosophila SMAD on the X chromosome."; RL Biochem. Biophys. Res. Commun. 252:195-201(1998). CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU361195}. CC Nucleus {ECO:0000256|RuleBase:RU361195}. CC -!- SIMILARITY: Belongs to the dwarfin/SMAD family. CC {ECO:0000256|RuleBase:RU361195}. CC -!- SIMILARITY: Contains 1 MH1 (MAD homology 1) domain. CC {ECO:0000256|RuleBase:RU361195}. CC -!- SIMILARITY: Contains 1 MH2 (MAD homology 2) domain. CC {ECO:0000256|RuleBase:RU361195}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF078529; AAC83344.1; -; mRNA. DR PIR; JE0341; JE0341. DR ProteinModelPortal; Q9TZQ2; -. DR IntAct; Q9TZQ2; 1. DR STRING; 7227.FBpp0071140; -. DR PaxDb; Q9TZQ2; -. DR PRIDE; Q9TZQ2; -. DR FlyBase; FBgn0025800; Smox. DR eggNOG; ENOG410XQKU; LUCA. DR eggNOG; KOG3701; Eukaryota. DR Reactome; R-DME-1181150; Signaling by NODAL. DR Reactome; R-DME-1502540; Signaling by Activin. DR Reactome; R-DME-2173788; Downregulation of TGF-beta receptor signaling. DR Reactome; R-DME-2173789; TGF-beta receptor signaling activates SMADs. DR Reactome; R-DME-2173795; Downregulation of SMAD2/3:SMAD4 transcriptional activity. DR Reactome; R-DME-2173796; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription. DR Bgee; Q9TZQ2; -. DR ExpressionAtlas; Q9TZQ2; differential. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0005667; C:transcription factor complex; IEA:InterPro. DR GO; GO:0031490; F:chromatin DNA binding; IDA:FlyBase. DR GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IEA:InterPro. DR GO; GO:0007411; P:axon guidance; IMP:FlyBase. DR GO; GO:0048813; P:dendrite morphogenesis; NAS:FlyBase. DR GO; GO:0008340; P:determination of adult lifespan; IMP:FlyBase. DR GO; GO:0007476; P:imaginal disc-derived wing morphogenesis; IMP:FlyBase. DR GO; GO:0016319; P:mushroom body development; IMP:FlyBase. DR GO; GO:0010507; P:negative regulation of autophagy; IMP:FlyBase. DR GO; GO:0048666; P:neuron development; IMP:FlyBase. DR GO; GO:0090256; P:regulation of cell proliferation involved in imaginal disc-derived wing morphogenesis; IMP:FlyBase. DR GO; GO:0007346; P:regulation of mitotic cell cycle; IMP:FlyBase. DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW. DR GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IEA:InterPro. DR Gene3D; 2.60.200.10; -; 1. DR Gene3D; 3.90.520.10; -; 1. DR InterPro; IPR013790; Dwarfin. DR InterPro; IPR003619; MAD_homology1_Dwarfin-type. DR InterPro; IPR013019; MAD_homology_MH1. DR InterPro; IPR017855; SMAD_dom-like. DR InterPro; IPR001132; SMAD_dom_Dwarfin-type. DR InterPro; IPR008984; SMAD_FHA_domain. DR PANTHER; PTHR13703; PTHR13703; 2. DR Pfam; PF03165; MH1; 1. DR Pfam; PF03166; MH2; 1. DR SMART; SM00523; DWA; 1. DR SMART; SM00524; DWB; 1. DR SUPFAM; SSF49879; SSF49879; 1. DR SUPFAM; SSF56366; SSF56366; 1. DR PROSITE; PS51075; MH1; 1. DR PROSITE; PS51076; MH2; 1. PE 2: Evidence at transcript level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Cytoplasm {ECO:0000256|RuleBase:RU361195}; KW DNA-binding {ECO:0000256|RuleBase:RU361195}; KW Nucleus {ECO:0000256|RuleBase:RU361195, KW ECO:0000256|SAAS:SAAS00464850}; KW Transcription {ECO:0000256|RuleBase:RU361195, KW ECO:0000256|SAAS:SAAS00464862}; KW Transcription regulation {ECO:0000256|RuleBase:RU361195, KW ECO:0000256|SAAS:SAAS00464859}. FT DOMAIN 7 132 MH1 (MAD homology 1). FT {ECO:0000259|PROSITE:PS51075}. FT DOMAIN 291 484 MH2 (MAD homology 2). FT {ECO:0000259|PROSITE:PS51076}. FT COILED 30 57 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 484 AA; 53475 MW; 9558C5C61A8EC812 CRC64; MLPFTPQVVK RLLALKKGNE DNSVEGKWSE KAVKNLVKKI KKQLEELERA ISTQNCQTRC VTVPRSKPAP AGEHLRKGLP HVIYCRLWRW PDLQSQNELK PLDHCEYAFH LRKEEICINP YHYKKIELSI LVPKSLPTPP DSIVDYPLDN HTHQIPNNTD YNAAIIRSAS LSPPQYMELG GAGPVSVSSS ASSTPATAAG GGGGPSSSSS SSSSAASAYQ QQQQQLSFGQ NMDSQSSVLS VGSSIPNTGT PPPGYMSEDG DPIDPNDNMN MSRLTPPADA APVMYHEPAF WCSISYYELN TRVGETFHAS QPSITVDGFT DPSNSERFCL GLLSNVNRNE VVEQTRRHIG KGVRLYYIGG EVFAECLSDS SIFVQSPNCN QRYGWHPATV CKIPPGCNLK IFNNQEFAAL LSQSVSQGFE AVYQLTRMCT IRMSFVKGWG AEYRRQTVTS TPCWIELHLN GPLQWLDRVL TQMGSPRLPC SSMS //