ID Q9TZL8_CAEEL Unreviewed; 814 AA. AC Q9TZL8; DT 01-MAY-2000, integrated into UniProtKB/TrEMBL. DT 01-OCT-2001, sequence version 2. DT 03-OCT-2012, entry version 89. DE RecName: Full=6-phosphofructokinase; DE EC=2.7.1.11; DE AltName: Full=Phosphohexokinase; GN ORFNames=CELE_Y71H10A.1, Y71H10A.1; OS Caenorhabditis elegans. OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; OC Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis. OX NCBI_TaxID=6239; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Bristol N2; RX MEDLINE=99069613; PubMed=9851916; DOI=10.1126/science.282.5396.2012; RG The C. elegans sequencing consortium; RT "Genome sequence of the nematode C. elegans: a platform for RT investigating biology."; RL Science 282:2012-2018(1998). CC -!- CATALYTIC ACTIVITY: ATP + D-fructose 6-phosphate = ADP + D- CC fructose 1,6-bisphosphate. CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3- CC phosphate and glycerone phosphate from D-glucose: step 3/4. CC -!- SIMILARITY: Belongs to the phosphofructokinase family. Two domains CC subfamily. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; FO081433; CCD71595.1; -; Genomic_DNA. DR PIR; T33481; T33481. DR RefSeq; NP_741738.1; NM_171643.3. DR UniGene; Cel.6857; -. DR HSSP; P00512; 3PFK. DR ProteinModelPortal; Q9TZL8; -. DR SMR; Q9TZL8; 42-792. DR STRING; Q9TZL8; -. DR PRIDE; Q9TZL8; -. DR EnsemblMetazoa; Y71H10A; Y71H10A; Y71H10A. DR GeneID; 180583; -. DR KEGG; cel:Y71H10A.1; -. DR UCSC; Y71H10A.1b.3; c. elegans. DR CTD; 180583; -. DR WormBase; Y71H10A.1a; CE28266; WBGene00022199; -. DR HOGENOM; HOG000200154; -. DR InParanoid; Q9TZL8; -. DR KO; K00850; -. DR OMA; CKAFTTR; -. DR UniPathway; UPA00109; UER00182. DR NextBio; 909990; -. DR ArrayExpress; Q9TZL8; -. DR GO; GO:0005945; C:6-phosphofructokinase complex; IEA:InterPro. DR GO; GO:0003872; F:6-phosphofructokinase activity; IEA:EC. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase. DR GO; GO:0006096; P:glycolysis; IEA:UniProtKB-KW. DR HAMAP; MF_00339; Phosphofructokinase; 1; -. DR InterPro; IPR009161; 6-phosphofructokinase_euk. DR InterPro; IPR022953; Phosphofructokinase. DR InterPro; IPR015912; Phosphofructokinase_CS. DR InterPro; IPR000023; Phosphofructokinase_dom. DR Pfam; PF00365; PFK; 2. DR PIRSF; PIRSF000533; ATP_PFK_euk; 1. DR PRINTS; PR00476; PHFRCTKINASE. DR SUPFAM; SSF53784; Ppfruckinase; 2. DR TIGRFAMs; TIGR02478; 6PF1K_euk; 1. DR PROSITE; PS00433; PHOSPHOFRUCTOKINASE; 2. PE 2: Evidence at transcript level; KW ATP-binding; Complete proteome; Glycolysis; Kinase; KW Nucleotide-binding; Reference proteome; Transferase. SQ SEQUENCE 814 AA; 89734 MW; DA829E8969EDF1CE CRC64; MDADASTITP EELDFIRQRA LRRFDSIVPT AGREGTEIAS DIFKGRTLAI YTSGGDSQGM NSAVRSITRM AIYCGCKVYL IYEGYEGMIE GGDFIKEATW NTVSDIIQQG GTIIGSARSS EFRTREGRLK AATNLINRGI GRLVCIGGDG SLTGANTFRL EWTDLVQELV KNQRVTAAAA KKIPYIQIVG LVGSIDNDFC GTDMTIGTDS ALQRIISSID AVVATAQSHQ RAFVIEVMGR HCGYLALVAA LASEADFCFI PEWPAPENWR DVLCDKLSQM RSEGQRLNII IVAEGAIDRD GKAITAEDVK TAVKEKLKYD TRVTILGHVQ RGGAPSAFDR LLGCRMGAEA VFALMEMTEE SEPCVISIDG NVMVRVPLLK CVERTQMVQK AMADKDWTTA VMLRGRSFQR NLETYKLLTK MRTVEKDNLS EGHKFNVAVI NVGAPAGGMN AAVRSYVRMA LYHQCTVYGI EDSFEGLANG SFKQFKWSDV TNWAMNGGSF LGTQKSLPTE KTMPQLAAQL KKHNIQALLL VGGFEAYHST IILAENREKY PEFCIPMCVI PCTISNNVPG TMVSLGSDTA INEICQMIDK IKQSATGTKR RVFIVETMGG YCGYLATLSA LSSGADNAYI FEEPFTVQDL SDDVDVILSK MEVGAKRYLV VRNEWADKNL TTDFVQNLFD SEGKKNFTTR VNVLGHVQQG GSPTPFDRNM GTKLAARALE FLLIQLKENL TADNKVIAKS AHTATLLGLK GRKVVFTPVQ DLKKETDFEH RLPSEQWWMA LRPLLRVLAR HRSTVESSAI LESVEEESAD SHMF //