ID   Q9TXM0_CAEEL            Unreviewed;       514 AA.
AC   Q9TXM0; G4SE31;
DT   01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 3.
DT   12-AUG-2020, entry version 143.
DE   SubName: Full=Aldedh domain-containing protein {ECO:0000313|EMBL:CCD72650.1};
GN   Name=alh-2 {ECO:0000313|EMBL:CCD72650.1,
GN   ECO:0000313|WormBase:K04F1.15};
GN   ORFNames=CELE_K04F1.15 {ECO:0000313|EMBL:CCD72650.1}, K04F1.15
GN   {ECO:0000313|WormBase:K04F1.15};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD72650.1, ECO:0000313|Proteomes:UP000001940};
RN   [1] {ECO:0000313|EMBL:CCD72650.1, ECO:0000313|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD72650.1,
RC   ECO:0000313|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RA   Sulson J.E., Waterston R.;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU003345}.
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DR   EMBL; BX284605; CCD72650.1; -; Genomic_DNA.
DR   RefSeq; NP_503467.2; NM_071066.2.
DR   SMR; Q9TXM0; -.
DR   STRING; 6239.K04F1.15; -.
DR   PaxDb; Q9TXM0; -.
DR   PeptideAtlas; Q9TXM0; -.
DR   EnsemblMetazoa; K04F1.15.1; K04F1.15.1; WBGene00000108.
DR   GeneID; 187001; -.
DR   KEGG; cel:CELE_K04F1.15; -.
DR   UCSC; K04F1.15; c. elegans.
DR   CTD; 187001; -.
DR   WormBase; K04F1.15; CE45828; WBGene00000108; alh-2.
DR   eggNOG; KOG2450; Eukaryota.
DR   GeneTree; ENSGT00940000168475; -.
DR   HOGENOM; CLU_005391_0_0_1; -.
DR   InParanoid; Q9TXM0; -.
DR   KO; K00128; -.
DR   OMA; SGQICNA; -.
DR   OrthoDB; 153834at2759; -.
DR   Reactome; R-CEL-5365859; RA biosynthesis pathway.
DR   Reactome; R-CEL-70350; Fructose catabolism.
DR   Reactome; R-CEL-71384; Ethanol oxidation.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00000108; Expressed in material anatomical entity and 2 other tissues.
DR   GO; GO:0004029; F:aldehyde dehydrogenase (NAD+) activity; IBA:GO_Central.
DR   Gene3D; 3.40.309.10; -; 1.
DR   Gene3D; 3.40.605.10; -; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; SSF53720; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   1: Evidence at protein level;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU003345};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:Q9TXM0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001940}.
FT   DOMAIN          42..505
FT                   /note="Aldedh"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   ACT_SITE        282
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
FT   ACT_SITE        316
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10008"
SQ   SEQUENCE   514 AA;  55836 MW;  F0C37327CA5B08E2 CRC64;
     MDSSLLRSAV RASVQACNGS GLPPGLADFK PKYTSLFINN EFVDAKSGKT FEFVNPANGK
     LLAKVAEGNR DDVDIAVEAA KKAFKIGSEW RRMDASHRGV LLNRLADLME RDRVILASLE
     SLDNGKPYKE AYNIDLPISI KTFRYYAGYA DKNHGKTIPV GGDYFTYTRH EPVGVCGQII
     PWNFPLLMQA WKLAPALAMG NTVVMKVAVK TPLSALHVAS LIKEAQFPEG VVNIIPGRGT
     DAGEAIASHM DVDKVAFTGS TEVGKTIMKA AAESNVKKVT LELGGKSPNI VFADADLEEA
     VRQSHHALFF NQGQCCSAGS RTFVEGKIYD EFVAKAKELV EKTVIGDPFD ENTTQGPQID
     ESQVETIMKY IESGKKEGAQ LVTGGVKHGD QGYFVKPTIF ANVNDQMKIA QEEIFGPVMI
     VIRFDSMEEL IEKANNTIYG LAAGVVTNDL NKALQVANTI RAGSVWVNCY DVFDPAAPFG
     GFKQSGIGRE LGEYGLAAYT EVKTVTIKVP QKNS
//