ID PAN_ARATH Reviewed; 452 AA. AC Q9SX27; Q9ZPJ6; DT 05-OCT-2010, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-2000, sequence version 1. DT 14-DEC-2022, entry version 140. DE RecName: Full=Transcription factor PERIANTHIA; DE AltName: Full=bZIP transcription factor 46; DE Short=AtbZIP46; GN Name=PAN; OrderedLocusNames=At1g68640; ORFNames=F24J5.12; OS Arabidopsis thaliana (Mouse-ear cress). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis. OX NCBI_TaxID=3702; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE, FUNCTION, AND RP DISRUPTION PHENOTYPE. RX PubMed=9990857; DOI=10.1101/gad.13.3.334; RA Chuang C.F., Running M.P., Williams R.W., Meyerowitz E.M.; RT "The PERIANTHIA gene encodes a bZIP protein involved in the determination RT of floral organ number in Arabidopsis thaliana."; RL Genes Dev. 13:334-344(1999). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Columbia; RX PubMed=11130712; DOI=10.1038/35048500; RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L., RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., RA Yu G., Fraser C.M., Venter J.C., Davis R.W.; RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."; RL Nature 408:816-820(2000). RN [3] RP GENOME REANNOTATION. RC STRAIN=cv. Columbia; RX PubMed=27862469; DOI=10.1111/tpj.13415; RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S., RA Town C.D.; RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference RT genome."; RL Plant J. 89:789-804(2017). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=cv. Columbia; RX PubMed=11910074; DOI=10.1126/science.1071006; RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T., RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y., RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K., RA Shinagawa A., Shinozaki K.; RT "Functional annotation of a full-length Arabidopsis cDNA collection."; RL Science 296:141-145(2002). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=cv. Columbia; RX PubMed=14593172; DOI=10.1126/science.1088305; RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L., RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., RA Ecker J.R.; RT "Empirical analysis of transcriptional activity in the Arabidopsis RT genome."; RL Science 302:842-846(2003). RN [6] RP DISRUPTION PHENOTYPE. RX PubMed=8620853; DOI=10.1242/dev.122.4.1261; RA Running M.P., Meyerowitz E.M.; RT "Mutations in the PERIANTHIA gene of Arabidopsis specifically alter floral RT organ number and initiation pattern."; RL Development 122:1261-1269(1996). RN [7] RP GENE FAMILY, AND NOMENCLATURE. RX PubMed=11906833; DOI=10.1016/s1360-1385(01)02223-3; RA Jakoby M., Weisshaar B., Droege-Laser W., Vicente-Carbajosa J., RA Tiedemann J., Kroj T., Parcy F.; RT "bZIP transcription factors in Arabidopsis."; RL Trends Plant Sci. 7:106-111(2002). RN [8] RP INTERACTION WITH BOP1 AND BOP2. RX PubMed=15805484; DOI=10.1105/tpc.104.030536; RA Hepworth S.R., Zhang Y., McKim S., Li X., Haughn G.W.; RT "BLADE-ON-PETIOLE-dependent signaling controls leaf and floral patterning RT in Arabidopsis."; RL Plant Cell 17:1434-1448(2005). RN [9] RP FUNCTION. RX PubMed=19395638; DOI=10.1242/dev.035436; RA Das P., Ito T., Wellmer F., Vernoux T., Dedieu A., Traas J., RA Meyerowitz E.M.; RT "Floral stem cell termination involves the direct regulation of AGAMOUS by RT PERIANTHIA."; RL Development 136:1605-1611(2009). RN [10] RP FUNCTION. RX PubMed=19395639; DOI=10.1242/dev.033647; RA Maier A.T., Stehling-Sun S., Wollmann H., Demar M., Hong R.L., Haubeiss S., RA Weigel D., Lohmann J.U.; RT "Dual roles of the bZIP transcription factor PERIANTHIA in the control of RT floral architecture and homeotic gene expression."; RL Development 136:1613-1620(2009). RN [11] RP INTERACTION WITH GRXC7/ROXY1, AND MUTAGENESIS OF CYS-340. RX PubMed=19218396; DOI=10.1105/tpc.108.064477; RA Li S., Lauri A., Ziemann M., Busch A., Bhave M., Zachgo S.; RT "Nuclear activity of ROXY1, a glutaredoxin interacting with TGA factors, is RT required for petal development in Arabidopsis thaliana."; RL Plant Cell 21:429-441(2009). CC -!- FUNCTION: Transcriptional activator involved in the determination of CC floral organ number. Acts to determine floral organ patterning by CC establishing floral organ primordia in specific numbers and positions. CC Plays a role in regulating stem cell fate by directly controlling AG CC expression. Binds to the 5'-AAGAAT-3' cis-acting element found in AG CC promoter. Might represent a target for a post-translational CC modification by GRXC7/ROXY1. {ECO:0000269|PubMed:19395638, CC ECO:0000269|PubMed:19395639, ECO:0000269|PubMed:9990857}. CC -!- SUBUNIT: Interacts with GRXC7/ROXY1. Interacts with BOP1 and BOP2. CC {ECO:0000269|PubMed:15805484, ECO:0000269|PubMed:19218396}. CC -!- INTERACTION: CC Q9SX27; Q96305: GRXC7; NbExp=3; IntAct=EBI-2257975, EBI-2257898; CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}. CC -!- DEVELOPMENTAL STAGE: Expressed in the apical meristem, the floral CC meristem, each whorl of organ primordia, and in ovule primordia during CC wild-type flower development. {ECO:0000269|PubMed:9990857}. CC -!- DISRUPTION PHENOTYPE: Mutant plants have extra floral organs. The modal CC numbers of organs in mutant flowers are 5 sepals, 5 petals, 5 stamens, CC and 2 carpels in contrast with the tetramerous pattern of the wild CC type. {ECO:0000269|PubMed:8620853, ECO:0000269|PubMed:9990857}. CC -!- SIMILARITY: Belongs to the bZIP family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AAD19660.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF111711; AAD19660.1; ALT_SEQ; Genomic_DNA. DR EMBL; AC008075; AAD49979.1; -; Genomic_DNA. DR EMBL; CP002684; AEE34822.1; -; Genomic_DNA. DR EMBL; AK118286; BAC42904.1; -; mRNA. DR EMBL; BT008586; AAP40413.1; -; mRNA. DR PIR; H96710; H96710. DR RefSeq; NP_177031.1; NM_105536.4. DR AlphaFoldDB; Q9SX27; -. DR SMR; Q9SX27; -. DR BioGRID; 28415; 3. DR IntAct; Q9SX27; 4. DR STRING; 3702.AT1G68640.1; -. DR PaxDb; Q9SX27; -. DR ProteomicsDB; 248659; -. DR EnsemblPlants; AT1G68640.1; AT1G68640.1; AT1G68640. DR GeneID; 843194; -. DR Gramene; AT1G68640.1; AT1G68640.1; AT1G68640. DR KEGG; ath:AT1G68640; -. DR Araport; AT1G68640; -. DR TAIR; locus:2026890; AT1G68640. DR eggNOG; ENOG502QWDU; Eukaryota. DR HOGENOM; CLU_024782_1_3_1; -. DR InParanoid; Q9SX27; -. DR OMA; ASANLHY; -. DR OrthoDB; 1018848at2759; -. DR PhylomeDB; Q9SX27; -. DR PRO; PR:Q9SX27; -. DR Proteomes; UP000006548; Chromosome 1. DR ExpressionAtlas; Q9SX27; baseline and differential. DR Genevisible; Q9SX27; AT. DR GO; GO:0005634; C:nucleus; IDA:TAIR. DR GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IPI:TAIR. DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:TAIR. DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR. DR GO; GO:0009909; P:regulation of flower development; IMP:TAIR. DR InterPro; IPR004827; bZIP. DR InterPro; IPR046347; bZIP_sf. DR InterPro; IPR025422; TGA_domain. DR Pfam; PF00170; bZIP_1; 1. DR Pfam; PF14144; DOG1; 1. DR SMART; SM00338; BRLZ; 1. DR SUPFAM; SSF57959; Leucine zipper domain; 1. DR PROSITE; PS50217; BZIP; 1. DR PROSITE; PS00036; BZIP_BASIC; 1. DR PROSITE; PS51806; DOG1; 1. PE 1: Evidence at protein level; KW Activator; Coiled coil; DNA-binding; Nucleus; Reference proteome; KW Transcription; Transcription regulation. FT CHAIN 1..452 FT /note="Transcription factor PERIANTHIA" FT /id="PRO_0000398152" FT DOMAIN 164..227 FT /note="bZIP" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978" FT DOMAIN 233..449 FT /note="DOG1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01147" FT REGION 166..186 FT /note="Basic motif" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978" FT REGION 192..206 FT /note="Leucine-zipper" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978" FT MUTAGEN 340 FT /note="C->A: Abolishes function in flower development." FT /evidence="ECO:0000269|PubMed:19218396" SQ SEQUENCE 452 AA; 50458 MW; 06CE2D1837AC261C CRC64; MQSSFKTVPF TPDFYSQSSY FFRGDSCLEE FHQPVNGFHH EEAIDLSPNV TIASANLHYT TFDTVMDCGG GGGGGLRERL EGGEEECLDT GQLVYQKGTR LVGGGVGEVN SSWCDSVSAM ADNSQHTDTS TDIDTDDKTQ LNGGHQGMLL ATNCSDQSNV KSSDQRTLRR LAQNREAARK SRLRKKAYVQ QLENSRIRLA QLEEELKRAR QQGSLVERGV SADHTHLAAG NGVFSFELEY TRWKEEHQRM INDLRSGVNS QLGDNDLRVL VDAVMSHYDE IFRLKGIGTK VDVFHMLSGM WKTPAERFFM WLGGFRSSEL LKILGNHVDP LTDQQLIGIC NLQQSSQQAE DALSQGMEAL QQSLLETLSS ASMGPNSSAN VADYMGHMAM AMGKLGTLEN FLRQADLLRQ QTLQQLHRIL TTRQAARAFL VIHDYISRLR ALSSLWLARP RD //