ID NUDT7_ARATH Reviewed; 282 AA. AC Q9SU14; Q8LEK5; DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-2000, sequence version 1. DT 24-MAR-2009, entry version 52. DE RecName: Full=Nudix hydrolase 7; DE Short=AtNUDT7; DE EC=3.6.1.-; DE AltName: Full=ADP-ribose pyrophosphatase; DE EC=3.6.1.13; DE AltName: Full=NADH pyrophosphatase; DE EC=3.6.1.22; GN Name=NUDT7; OrderedLocusNames=At4g12720; ORFNames=T20K18.70; OS Arabidopsis thaliana (Mouse-ear cress). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons; OC rosids; eurosids II; Brassicales; Brassicaceae; Arabidopsis. OX NCBI_TaxID=3702; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Columbia; RX MEDLINE=20083488; PubMed=10617198; DOI=10.1038/47134; RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., RA Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., RA Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., RA Weichselgartner M., de Simone V., Obermaier B., Mache R., Mueller M., RA Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., RA Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., RA Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., RA Langham S.-A., McCullagh B., Bilham L., Robben J., RA van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., RA Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., RA Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., RA Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., RA Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., RA De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., RA van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., RA Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., RA Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., RA Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., RA Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., RA Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., RA Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., RA Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., RA Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., RA Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., RA Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., RA Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., RA Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., RA Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., RA Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., RA Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., RA Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., RA Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., RA Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., RA Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., RA Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., RA Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., RA Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., RA Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., RA Chen E., Marra M.A., Martienssen R., McCombie W.R.; RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis RT thaliana."; RL Nature 402:769-777(1999). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=cv. Columbia; RX MEDLINE=22954850; PubMed=14593172; DOI=10.1126/science.1088305; RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., RA Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., RA Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G., RA Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., RA Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., RA Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., RA Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., RA Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., RA Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., RA Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., RA Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., RA Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.; RT "Empirical analysis of transcriptional activity in the Arabidopsis RT genome."; RL Science 302:842-846(2003). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., RA Feldmann K.A.; RT "Full-length cDNA from Arabidopsis thaliana."; RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases. RN [4] RP FUNCTION IN VITRO, AND TISSUE SPECIFICITY. RX PubMed=15878881; DOI=10.1074/jbc.M503536200; RA Ogawa T., Ueda Y., Yoshimura K., Shigeoka S.; RT "Comprehensive analysis of cytosolic nudix hydrolases in Arabidopsis RT thaliana."; RL J. Biol. Chem. 280:25277-25283(2005). CC -!- FUNCTION: Probably mediates the hydrolysis of some nucleoside CC diphosphate derivatives. In vitro, it can use both NADH and ADP- CC ribose as substrates; however the relevance of such substrates in CC vivo is unclear. CC -!- CATALYTIC ACTIVITY: ADP-ribose + H(2)O = AMP + D-ribose 5- CC phosphate. CC -!- CATALYTIC ACTIVITY: NAD(+) + H(2)O = AMP + NMN. CC -!- COFACTOR: Magnesium or manganese (By similarity). CC -!- TISSUE SPECIFICITY: Expressed in stems and leaves. Weakly or not CC expressed in roots. CC -!- SIMILARITY: Belongs to the Nudix hydrolase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL049640; CAB40989.1; -; Genomic_DNA. DR EMBL; AL161534; CAB78314.1; -; Genomic_DNA. DR EMBL; AF325104; AAK17172.1; -; mRNA. DR EMBL; AF370209; AAK44024.1; -; mRNA. DR EMBL; AY056344; AAL07193.1; -; mRNA. DR EMBL; AY085375; AAM62604.1; -; mRNA. DR IPI; IPI00537463; -. DR PIR; T06630; T06630. DR RefSeq; NP_193008.1; -. DR RefSeq; NP_849367.1; -. DR RefSeq; NP_849368.1; -. DR UniGene; At.23449; -. DR PRIDE; Q9SU14; -. DR ProMEX; Q9SU14; -. DR GeneID; 826884; -. DR GenomeReviews; CT486007_GR; AT4G12720. DR KEGG; ath:AT4G12720; -. DR NMPDR; fig|3702.1.peg.18947; -. DR TAIR; At4g12720; -. DR BRENDA; 3.6.1.13; 302. DR BRENDA; 3.6.1.22; 302. DR GermOnline; AT4G12720; Arabidopsis thaliana. DR GO; GO:0047631; F:ADP-ribose diphosphatase activity; IEA:EC. DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-KW. DR GO; GO:0030145; F:manganese ion binding; IEA:UniProtKB-KW. DR GO; GO:0051287; F:NAD or NADH binding; IDA:TAIR. DR GO; GO:0000210; F:NAD+ diphosphatase activity; IEA:EC. DR GO; GO:0017110; F:nucleoside-diphosphatase activity; IDA:TAIR. DR GO; GO:0042803; F:protein homodimerization activity; IDA:TAIR. DR GO; GO:0009870; P:defense response signaling pathway, resista...; IMP:TAIR. DR GO; GO:0042742; P:defense response to bacterium; IMP:TAIR. DR GO; GO:0009626; P:plant-type hypersensitive response; IMP:TAIR. DR GO; GO:0006979; P:response to oxidative stress; IEP:TAIR. DR GO; GO:0010193; P:response to ozone; IEP:TAIR. DR GO; GO:0009651; P:response to salt stress; IEP:TAIR. DR InterPro; IPR003293; GFG_antis. DR InterPro; IPR000086; NUDIX_hydrolase_core. DR Gene3D; G3DSA:3.90.79.10; NUDIX_hydrolase; 1. DR Pfam; PF00293; NUDIX; 1. DR PRINTS; PR01356; GFGPROTEIN. DR PROSITE; PS00893; NUDIX; 1. PE 1: Evidence at protein level; KW Complete proteome; Hydrolase; Magnesium; Manganese; Metal-binding; KW NAD. FT CHAIN 1 282 Nudix hydrolase 7. FT /FTId=PRO_0000057127. FT MOTIF 139 160 Nudix box. FT METAL 154 154 Magnesium or manganese (By similarity). FT METAL 158 158 Magnesium or manganese (By similarity). FT CONFLICT 6 6 Q -> L (in Ref. 3; AAM62604). FT CONFLICT 217 217 V -> I (in Ref. 3; AAM62604). SQ SEQUENCE 282 AA; 31884 MW; EA37FC0F1C2FDCB7 CRC64; MGTRAQQIPL LEGETDNYDG VTVTMVEPMD SEVFTESLRA SLSHWREEGK KGIWIKLPLG LANLVEAAVS EGFRYHHAEP EYLMLVSWIS ETPDTIPANA SHVVGAGALV INKNTKEVLV VQERSGFFKD KNVWKLPTGV INEGEDIWTG VAREVEEETG IIADFVEVLA FRQSHKAILK KKTDMFFLCV LSPRSYDITE QKSEILQAKW MPIQEYVDQP WNKKNEMFKF MANICQKKCE EEYLGFAIVP TTTSSGKESF IYCNADHAKR LKVSRDQASA SL //