ID FBT3_ARATH Reviewed; 497 AA. AC Q9SQN2; DT 31-OCT-2012, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-2000, sequence version 1. DT 29-MAY-2024, entry version 124. DE RecName: Full=Probable folate-biopterin transporter 3; GN OrderedLocusNames=At1g79710; ORFNames=F19K16.31, F20B17.13; OS Arabidopsis thaliana (Mouse-ear cress). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis. OX NCBI_TaxID=3702; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Columbia; RX PubMed=11130712; DOI=10.1038/35048500; RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L., RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., RA Yu G., Fraser C.M., Venter J.C., Davis R.W.; RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."; RL Nature 408:816-820(2000). RN [2] RP GENOME REANNOTATION. RC STRAIN=cv. Columbia; RX PubMed=27862469; DOI=10.1111/tpj.13415; RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S., RA Town C.D.; RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference RT genome."; RL Plant J. 89:789-804(2017). RN [3] RP GENE FAMILY. RX PubMed=16162503; DOI=10.1074/jbc.m507432200; RA Klaus S.M., Kunji E.R., Bozzo G.G., Noiriel A., de la Garza R.D., RA Basset G.J., Ravanel S., Rebeille F., Gregory J.F. III, Hanson A.D.; RT "Higher plant plastids and cyanobacteria have folate carriers related to RT those of trypanosomatids."; RL J. Biol. Chem. 280:38457-38463(2005). CC -!- FUNCTION: Could mediate folate transport. {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane CC protein {ECO:0000305}. CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Folate- CC biopterin transporter (TC 2.A.71) family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC010793; AAF68109.1; -; Genomic_DNA. DR EMBL; AC011717; AAG52252.1; -; Genomic_DNA. DR EMBL; CP002684; AEE36290.1; -; Genomic_DNA. DR EMBL; CP002684; ANM60453.1; -; Genomic_DNA. DR PIR; A96828; A96828. DR RefSeq; NP_001322738.1; NM_001334915.1. DR RefSeq; NP_178089.1; NM_106620.4. DR AlphaFoldDB; Q9SQN2; -. DR SMR; Q9SQN2; -. DR PaxDb; 3702-AT1G79710-1; -. DR ProteomicsDB; 222435; -. DR EnsemblPlants; AT1G79710.1; AT1G79710.1; AT1G79710. DR EnsemblPlants; AT1G79710.2; AT1G79710.2; AT1G79710. DR GeneID; 844310; -. DR Gramene; AT1G79710.1; AT1G79710.1; AT1G79710. DR Gramene; AT1G79710.2; AT1G79710.2; AT1G79710. DR KEGG; ath:AT1G79710; -. DR Araport; AT1G79710; -. DR TAIR; AT1G79710; -. DR eggNOG; ENOG502QPUV; Eukaryota. DR HOGENOM; CLU_018563_1_1_1; -. DR InParanoid; Q9SQN2; -. DR OMA; VSTQYYM; -. DR OrthoDB; 241511at2759; -. DR PhylomeDB; Q9SQN2; -. DR PRO; PR:Q9SQN2; -. DR Proteomes; UP000006548; Chromosome 1. DR ExpressionAtlas; Q9SQN2; baseline and differential. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR CDD; cd17484; MFS_FBT; 1. DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1. DR InterPro; IPR039309; BT1. DR InterPro; IPR004324; FBT. DR InterPro; IPR036259; MFS_trans_sf. DR NCBIfam; TIGR00788; fbt; 1. DR PANTHER; PTHR31585; FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC; 1. DR PANTHER; PTHR31585:SF11; FOLATE-BIOPTERIN TRANSPORTER 3-RELATED; 1. DR Pfam; PF03092; BT1; 1. DR SUPFAM; SSF103473; MFS general substrate transporter; 1. PE 2: Evidence at transcript level; KW Membrane; Reference proteome; Transmembrane; Transmembrane helix; KW Transport. FT CHAIN 1..497 FT /note="Probable folate-biopterin transporter 3" FT /id="PRO_0000420115" FT TRANSMEM 40..60 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 87..107 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 120..140 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 145..165 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 186..206 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 212..232 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 269..289 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 302..322 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 334..354 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 358..378 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 405..425 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 439..459 FT /note="Helical" FT /evidence="ECO:0000255" SQ SEQUENCE 497 AA; 55028 MW; 355EEE2CF20C0F97 CRC64; MANRSEEAEY ENDSRRNHQD KKKEGVLDLV LKRPLRWLRM LIEELHWSFF FGVIIVYGVS QGLGKGLSKV STQYYFKDEQ KIQPSQAQIY VGLIQIPWII KPLWGLLTDV VPVLGYRRRP YFILAGFLAM ISMMVLWLHT NLHLALALSC LVAGSAGVAI ADVTIDACVT QCSISHPTLA ADMQSLCGLC SSIGSLVGFS LSGVLVHLVG SKGVYGLLGV TAGLLVVVGM VLKESPSRSL GRKHVNDKFL DAGSAIWKTF QYGEVWRPCL FMLLSAAVSL HIHEGMFYWY TDSKDGPSFS KEAVGSIMSF GAIGSLVGIL LYQNFLKNFP FRNVVFWALS LSVLSGFLDL ILVLRINLKL GLPDYFFIVV DEFVSHMISR IKWLPLLVLS SKLCPAGMEG TFFALLMSIE HIGHLVSSWG GGVLLHALKV TRTQFDNLWL VIVIRSLLRV IPIGLVFLIP NVDSNSTILP AEMLTSRISE GVDTEKIEMT ALISDEA //