ID FBT3_ARATH Reviewed; 497 AA. AC Q9SQN2; DT 31-OCT-2012, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-2000, sequence version 1. DT 08-MAY-2019, entry version 103. DE RecName: Full=Probable folate-biopterin transporter 3; GN OrderedLocusNames=At1g79710; ORFNames=F19K16.31, F20B17.13; OS Arabidopsis thaliana (Mouse-ear cress). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; OC Arabidopsis. OX NCBI_TaxID=3702; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Columbia; RX PubMed=11130712; DOI=10.1038/35048500; RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., RA White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., RA Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., RA Chung M.K., Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., RA Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., RA Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., RA Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., RA Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., RA Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., RA Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., RA Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., RA Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., RA Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., RA Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., RA Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.; RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis RT thaliana."; RL Nature 408:816-820(2000). RN [2] RP GENOME REANNOTATION. RC STRAIN=cv. Columbia; RX PubMed=27862469; DOI=10.1111/tpj.13415; RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S., RA Town C.D.; RT "Araport11: a complete reannotation of the Arabidopsis thaliana RT reference genome."; RL Plant J. 89:789-804(2017). RN [3] RP GENE FAMILY. RX PubMed=16162503; DOI=10.1074/jbc.M507432200; RA Klaus S.M., Kunji E.R., Bozzo G.G., Noiriel A., de la Garza R.D., RA Basset G.J., Ravanel S., Rebeille F., Gregory J.F. III, Hanson A.D.; RT "Higher plant plastids and cyanobacteria have folate carriers related RT to those of trypanosomatids."; RL J. Biol. Chem. 280:38457-38463(2005). CC -!- FUNCTION: Could mediate folate transport. {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane CC protein {ECO:0000305}. CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Folate- CC biopterin transporter (TC 2.A.71) family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC010793; AAF68109.1; -; Genomic_DNA. DR EMBL; AC011717; AAG52252.1; -; Genomic_DNA. DR EMBL; CP002684; AEE36290.1; -; Genomic_DNA. DR EMBL; CP002684; ANM60453.1; -; Genomic_DNA. DR PIR; A96828; A96828. DR RefSeq; NP_001322738.1; NM_001334915.1. DR RefSeq; NP_178089.1; NM_106620.4. DR PaxDb; Q9SQN2; -. DR EnsemblPlants; AT1G79710.1; AT1G79710.1; AT1G79710. DR EnsemblPlants; AT1G79710.2; AT1G79710.2; AT1G79710. DR GeneID; 844310; -. DR Gramene; AT1G79710.1; AT1G79710.1; AT1G79710. DR Gramene; AT1G79710.2; AT1G79710.2; AT1G79710. DR KEGG; ath:AT1G79710; -. DR Araport; AT1G79710; -. DR TAIR; locus:2017814; AT1G79710. DR eggNOG; ENOG410IH1A; Eukaryota. DR eggNOG; ENOG4110MUE; LUCA. DR HOGENOM; HOG000240899; -. DR InParanoid; Q9SQN2; -. DR OMA; LMSIDHI; -. DR OrthoDB; 659174at2759; -. DR PhylomeDB; Q9SQN2; -. DR PRO; PR:Q9SQN2; -. DR Proteomes; UP000006548; Chromosome 1. DR ExpressionAtlas; Q9SQN2; baseline and differential. DR Genevisible; Q9SQN2; AT. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR CDD; cd06174; MFS; 1. DR InterPro; IPR039309; BT1. DR InterPro; IPR004324; FBT. DR InterPro; IPR020846; MFS_dom. DR InterPro; IPR036259; MFS_trans_sf. DR PANTHER; PTHR31585; PTHR31585; 1. DR Pfam; PF03092; BT1; 2. DR SUPFAM; SSF103473; SSF103473; 1. DR TIGRFAMs; TIGR00788; fbt; 1. PE 2: Evidence at transcript level; KW Complete proteome; Membrane; Reference proteome; Transmembrane; KW Transmembrane helix; Transport. FT CHAIN 1 497 Probable folate-biopterin transporter 3. FT /FTId=PRO_0000420115. FT TRANSMEM 40 60 Helical. {ECO:0000255}. FT TRANSMEM 87 107 Helical. {ECO:0000255}. FT TRANSMEM 120 140 Helical. {ECO:0000255}. FT TRANSMEM 145 165 Helical. {ECO:0000255}. FT TRANSMEM 186 206 Helical. {ECO:0000255}. FT TRANSMEM 212 232 Helical. {ECO:0000255}. FT TRANSMEM 269 289 Helical. {ECO:0000255}. FT TRANSMEM 302 322 Helical. {ECO:0000255}. FT TRANSMEM 334 354 Helical. {ECO:0000255}. FT TRANSMEM 358 378 Helical. {ECO:0000255}. FT TRANSMEM 405 425 Helical. {ECO:0000255}. FT TRANSMEM 439 459 Helical. {ECO:0000255}. SQ SEQUENCE 497 AA; 55028 MW; 355EEE2CF20C0F97 CRC64; MANRSEEAEY ENDSRRNHQD KKKEGVLDLV LKRPLRWLRM LIEELHWSFF FGVIIVYGVS QGLGKGLSKV STQYYFKDEQ KIQPSQAQIY VGLIQIPWII KPLWGLLTDV VPVLGYRRRP YFILAGFLAM ISMMVLWLHT NLHLALALSC LVAGSAGVAI ADVTIDACVT QCSISHPTLA ADMQSLCGLC SSIGSLVGFS LSGVLVHLVG SKGVYGLLGV TAGLLVVVGM VLKESPSRSL GRKHVNDKFL DAGSAIWKTF QYGEVWRPCL FMLLSAAVSL HIHEGMFYWY TDSKDGPSFS KEAVGSIMSF GAIGSLVGIL LYQNFLKNFP FRNVVFWALS LSVLSGFLDL ILVLRINLKL GLPDYFFIVV DEFVSHMISR IKWLPLLVLS SKLCPAGMEG TFFALLMSIE HIGHLVSSWG GGVLLHALKV TRTQFDNLWL VIVIRSLLRV IPIGLVFLIP NVDSNSTILP AEMLTSRISE GVDTEKIEMT ALISDEA //