ID   MED18_ARATH             Reviewed;         219 AA.
AC   Q9SJZ6;
DT   11-JUL-2012, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   12-APR-2017, entry version 83.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 18;
GN   Name=MED18; Synonyms=MED18_1; OrderedLocusNames=At2g22370;
GN   ORFNames=F14M13.23;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
OC   Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
OC   Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L.,
RA   Moffat K.S., Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L.,
RA   Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H.,
RA   Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D.,
RA   Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M.,
RA   Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis
RT   thaliana.";
RL   Nature 402:761-768(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RG   The Arabidopsis Information Portal (Araport);
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Bautista V.R., Kim C.J., Chen H., Quinitio C., Ecker J.R.;
RT   "Arabidopsis ORF clones.";
RL   Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY, SUBUNIT, AND NOMENCLATURE.
RX   PubMed=17560376; DOI=10.1016/j.molcel.2007.05.007;
RA   Baeckstroem S., Elfving N., Nilsson R., Wingsle G., Bjoerklund S.;
RT   "Purification of a plant mediator from Arabidopsis thaliana identifies
RT   PFT1 as the Med25 subunit.";
RL   Mol. Cell 26:717-729(2007).
RN   [5]
RP   IDENTIFICATION, AND NOMENCLATURE.
RX   PubMed=22021418; DOI=10.1104/pp.111.188300;
RA   Mathur S., Vyas S., Kapoor S., Tyagi A.K.;
RT   "The Mediator complex in plants: structure, phylogeny, and expression
RT   profiling of representative genes in a dicot (Arabidopsis) and a
RT   monocot (rice) during reproduction and abiotic stress.";
RL   Plant Physiol. 157:1609-1627(2011).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator
CC       involved in the regulated transcription of nearly all RNA
CC       polymerase II-dependent genes. Mediator functions as a bridge to
CC       convey information from gene-specific regulatory proteins to the
CC       basal RNA polymerase II transcription machinery. The Mediator
CC       complex, having a compact conformation in its free form, is
CC       recruited to promoters by direct interactions with regulatory
CC       proteins and serves for the assembly of a functional preinitiation
CC       complex with RNA polymerase II and the general transcription
CC       factors.
CC   -!- SUBUNIT: Component of the Mediator complex.
CC       {ECO:0000269|PubMed:17560376}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 18 family.
CC       {ECO:0000305}.
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DR   EMBL; AC006592; AAD22361.1; -; Genomic_DNA.
DR   EMBL; CP002685; AEC07298.1; -; Genomic_DNA.
DR   EMBL; BT029378; ABK32192.1; -; mRNA.
DR   PIR; H84611; H84611.
DR   RefSeq; NP_565534.1; NM_127802.4.
DR   UniGene; At.28136; -.
DR   ProteinModelPortal; Q9SJZ6; -.
DR   SMR; Q9SJZ6; -.
DR   BioGrid; 2122; 2.
DR   IntAct; Q9SJZ6; 1.
DR   STRING; 3702.AT2G22370.1; -.
DR   PaxDb; Q9SJZ6; -.
DR   EnsemblPlants; AT2G22370.1; AT2G22370.1; AT2G22370.
DR   GeneID; 816769; -.
DR   Gramene; AT2G22370.1; AT2G22370.1; AT2G22370.
DR   KEGG; ath:AT2G22370; -.
DR   Araport; AT2G22370; -.
DR   TAIR; locus:2041243; AT2G22370.
DR   eggNOG; ENOG410ISJX; Eukaryota.
DR   eggNOG; ENOG410ZUU9; LUCA.
DR   HOGENOM; HOG000005666; -.
DR   InParanoid; Q9SJZ6; -.
DR   KO; K15135; -.
DR   OMA; EPTWTVK; -.
DR   OrthoDB; EOG09360N9S; -.
DR   PhylomeDB; Q9SJZ6; -.
DR   PRO; PR:Q9SJZ6; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; Q9SJZ6; baseline and differential.
DR   Genevisible; Q9SJZ6; AT.
DR   GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
DR   GO; GO:0016592; C:mediator complex; IDA:UniProtKB.
DR   GO; GO:0001104; F:RNA polymerase II transcription cofactor activity; IBA:GO_Central.
DR   GO; GO:0048440; P:carpel development; IGI:TAIR.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:TAIR.
DR   GO; GO:0048441; P:petal development; IGI:TAIR.
DR   GO; GO:0048510; P:regulation of timing of transition from vegetative to reproductive phase; IMP:TAIR.
DR   GO; GO:0010219; P:regulation of vernalization response; IMP:TAIR.
DR   GO; GO:0048442; P:sepal development; IGI:TAIR.
DR   GO; GO:0048833; P:specification of floral organ number; IMP:TAIR.
DR   GO; GO:0048443; P:stamen development; IGI:TAIR.
DR   GO; GO:0006369; P:termination of RNA polymerase II transcription; IBA:GO_Central.
PE   1: Evidence at protein level;
KW   Complete proteome; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN         1    219       Mediator of RNA polymerase II
FT                                transcription subunit 18.
FT                                /FTId=PRO_0000418352.
FT   COMPBIAS    203    208       Poly-Ala.
SQ   SEQUENCE   219 AA;  23365 MW;  FE53D1C081F36F55 CRC64;
     MSMECVVQGI IETQHVEALE ILLQGLCGVQ RERLRVHELC LRSGPNLGVV SSEVRLLCDL
     DQPEPTWTVK HVGGAMRGAG ADQISVLVRN MIESKVSKNA LRMFYALGYK LDHELLKVGF
     AFHFQRTAHI SVSVSSVNKM PKVHAIDEAV PVTPGMQIVD VTAPATSENY SEVAAAVSSF
     CEFLAPLVHL SKPSISTGVV PTAAAAAASL MSDGGGTTL
//