ID MED18_ARATH Reviewed; 219 AA. AC Q9SJZ6; DT 11-JUL-2012, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-2000, sequence version 1. DT 12-APR-2017, entry version 83. DE RecName: Full=Mediator of RNA polymerase II transcription subunit 18; GN Name=MED18; Synonyms=MED18_1; OrderedLocusNames=At2g22370; GN ORFNames=F14M13.23; OS Arabidopsis thaliana (Mouse-ear cress). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; OC Arabidopsis. OX NCBI_TaxID=3702; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Columbia; RX PubMed=10617197; DOI=10.1038/45471; RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., RA Moffat K.S., Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., RA Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., RA Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., RA Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., RA Venter J.C.; RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis RT thaliana."; RL Nature 402:761-768(1999). RN [2] RP GENOME REANNOTATION. RC STRAIN=cv. Columbia; RG The Arabidopsis Information Portal (Araport); RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Bautista V.R., Kim C.J., Chen H., Quinitio C., Ecker J.R.; RT "Arabidopsis ORF clones."; RL Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases. RN [4] RP IDENTIFICATION BY MASS SPECTROMETRY, SUBUNIT, AND NOMENCLATURE. RX PubMed=17560376; DOI=10.1016/j.molcel.2007.05.007; RA Baeckstroem S., Elfving N., Nilsson R., Wingsle G., Bjoerklund S.; RT "Purification of a plant mediator from Arabidopsis thaliana identifies RT PFT1 as the Med25 subunit."; RL Mol. Cell 26:717-729(2007). RN [5] RP IDENTIFICATION, AND NOMENCLATURE. RX PubMed=22021418; DOI=10.1104/pp.111.188300; RA Mathur S., Vyas S., Kapoor S., Tyagi A.K.; RT "The Mediator complex in plants: structure, phylogeny, and expression RT profiling of representative genes in a dicot (Arabidopsis) and a RT monocot (rice) during reproduction and abiotic stress."; RL Plant Physiol. 157:1609-1627(2011). CC -!- FUNCTION: Component of the Mediator complex, a coactivator CC involved in the regulated transcription of nearly all RNA CC polymerase II-dependent genes. Mediator functions as a bridge to CC convey information from gene-specific regulatory proteins to the CC basal RNA polymerase II transcription machinery. The Mediator CC complex, having a compact conformation in its free form, is CC recruited to promoters by direct interactions with regulatory CC proteins and serves for the assembly of a functional preinitiation CC complex with RNA polymerase II and the general transcription CC factors. CC -!- SUBUNIT: Component of the Mediator complex. CC {ECO:0000269|PubMed:17560376}. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. CC -!- SIMILARITY: Belongs to the Mediator complex subunit 18 family. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC006592; AAD22361.1; -; Genomic_DNA. DR EMBL; CP002685; AEC07298.1; -; Genomic_DNA. DR EMBL; BT029378; ABK32192.1; -; mRNA. DR PIR; H84611; H84611. DR RefSeq; NP_565534.1; NM_127802.4. DR UniGene; At.28136; -. DR ProteinModelPortal; Q9SJZ6; -. DR SMR; Q9SJZ6; -. DR BioGrid; 2122; 2. DR IntAct; Q9SJZ6; 1. DR STRING; 3702.AT2G22370.1; -. DR PaxDb; Q9SJZ6; -. DR EnsemblPlants; AT2G22370.1; AT2G22370.1; AT2G22370. DR GeneID; 816769; -. DR Gramene; AT2G22370.1; AT2G22370.1; AT2G22370. DR KEGG; ath:AT2G22370; -. DR Araport; AT2G22370; -. DR TAIR; locus:2041243; AT2G22370. DR eggNOG; ENOG410ISJX; Eukaryota. DR eggNOG; ENOG410ZUU9; LUCA. DR HOGENOM; HOG000005666; -. DR InParanoid; Q9SJZ6; -. DR KO; K15135; -. DR OMA; EPTWTVK; -. DR OrthoDB; EOG09360N9S; -. DR PhylomeDB; Q9SJZ6; -. DR PRO; PR:Q9SJZ6; -. DR Proteomes; UP000006548; Chromosome 2. DR ExpressionAtlas; Q9SJZ6; baseline and differential. DR Genevisible; Q9SJZ6; AT. DR GO; GO:0070847; C:core mediator complex; IBA:GO_Central. DR GO; GO:0016592; C:mediator complex; IDA:UniProtKB. DR GO; GO:0001104; F:RNA polymerase II transcription cofactor activity; IBA:GO_Central. DR GO; GO:0048440; P:carpel development; IGI:TAIR. DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:TAIR. DR GO; GO:0048441; P:petal development; IGI:TAIR. DR GO; GO:0048510; P:regulation of timing of transition from vegetative to reproductive phase; IMP:TAIR. DR GO; GO:0010219; P:regulation of vernalization response; IMP:TAIR. DR GO; GO:0048442; P:sepal development; IGI:TAIR. DR GO; GO:0048833; P:specification of floral organ number; IMP:TAIR. DR GO; GO:0048443; P:stamen development; IGI:TAIR. DR GO; GO:0006369; P:termination of RNA polymerase II transcription; IBA:GO_Central. PE 1: Evidence at protein level; KW Complete proteome; Nucleus; Reference proteome; Transcription; KW Transcription regulation. FT CHAIN 1 219 Mediator of RNA polymerase II FT transcription subunit 18. FT /FTId=PRO_0000418352. FT COMPBIAS 203 208 Poly-Ala. SQ SEQUENCE 219 AA; 23365 MW; FE53D1C081F36F55 CRC64; MSMECVVQGI IETQHVEALE ILLQGLCGVQ RERLRVHELC LRSGPNLGVV SSEVRLLCDL DQPEPTWTVK HVGGAMRGAG ADQISVLVRN MIESKVSKNA LRMFYALGYK LDHELLKVGF AFHFQRTAHI SVSVSSVNKM PKVHAIDEAV PVTPGMQIVD VTAPATSENY SEVAAAVSSF CEFLAPLVHL SKPSISTGVV PTAAAAAASL MSDGGGTTL //