ID GC1_ARATH Reviewed; 347 AA. AC Q9SJU9; Q9FEG0; DT 29-OCT-2014, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2002, sequence version 2. DT 31-JUL-2019, entry version 128. DE RecName: Full=Epimerase family protein SDR39U1 homolog, chloroplastic {ECO:0000305}; DE EC=1.1.1.-; DE AltName: Full=Protein GIANT CHLOROPLAST 1 {ECO:0000303|PubMed:15120068}; DE AltName: Full=Protein SulA homolog {ECO:0000303|PubMed:15208387}; DE Short=AtSulA {ECO:0000303|PubMed:15208387}; DE Flags: Precursor; GN Name=GC1 {ECO:0000303|PubMed:15120068}; GN Synonyms=SULA {ECO:0000303|PubMed:15208387}; GN OrderedLocusNames=At2g21280 {ECO:0000312|Araport:AT2G21280}; GN ORFNames=F3K23; OS Arabidopsis thaliana (Mouse-ear cress). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; OC Arabidopsis. OX NCBI_TaxID=3702 {ECO:0000312}; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE RP SPECIFICITY. RC STRAIN=cv. Wassilewskija {ECO:0000305}; RX PubMed=15208387; DOI=10.1105/tpc.022335; RA Raynaud C., Cassier-Chauvat C., Perennes C., Bergounioux C.; RT "An Arabidopsis homolog of the bacterial cell division inhibitor SulA RT is involved in plastid division."; RL Plant Cell 16:1801-1811(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Columbia; RX PubMed=10617197; DOI=10.1038/45471; RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., RA Moffat K.S., Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., RA Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., RA Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., RA Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., RA Venter J.C.; RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis RT thaliana."; RL Nature 402:761-768(1999). RN [3] RP GENOME REANNOTATION. RC STRAIN=cv. Columbia; RX PubMed=27862469; DOI=10.1111/tpj.13415; RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S., RA Town C.D.; RT "Araport11: a complete reannotation of the Arabidopsis thaliana RT reference genome."; RL Plant J. 89:789-804(2017). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=cv. Columbia; RX PubMed=14593172; DOI=10.1126/science.1088305; RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., RA Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., RA Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G., RA Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., RA Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., RA Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., RA Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., RA Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., RA Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., RA Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., RA Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., RA Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.; RT "Empirical analysis of transcriptional activity in the Arabidopsis RT genome."; RL Science 302:842-846(2003). RN [5] RP FUNCTION, HOMODIMERIZATION, SUBCELLULAR LOCATION, AND TISSUE RP SPECIFICITY. RX PubMed=15120068; DOI=10.1016/j.cub.2004.04.031; RA Maple J., Fujiwara M.T., Kitahata N., Lawson T., Baker N.R., RA Yoshida S., Moller S.G.; RT "GIANT CHLOROPLAST 1 is essential for correct plastid division in RT Arabidopsis."; RL Curr. Biol. 14:776-781(2004). CC -!- FUNCTION: Putative NADP-dependent oxidoreductase that acts as CC positive regulator of chloroplast division. May play a role at an CC early stage of the division process. CC {ECO:0000269|PubMed:15120068}. CC -!- SUBUNIT: Can form homodimers. {ECO:0000269|PubMed:15120068}. CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast inner membrane; CC Peripheral membrane protein; Stromal side CC {ECO:0000269|PubMed:15120068}. Plastid, chloroplast CC {ECO:0000269|PubMed:15208387}. CC -!- TISSUE SPECIFICITY: Expressed in leaves, stems and flower buds. CC {ECO:0000269|PubMed:15120068, ECO:0000269|PubMed:15208387}. CC -!- MISCELLANEOUS: Plants silencing GC1 show greatly enlarged CC chloroplasts containing densely packed thylakoid membranes in CC mesophyll cells and leaves with decreased rates of CO(2) CC assimilation. {ECO:0000269|PubMed:15120068}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ516948; CAD56855.1; -; mRNA. DR EMBL; AC006841; AAD23676.2; -; Genomic_DNA. DR EMBL; CP002685; AEC07155.1; -; Genomic_DNA. DR EMBL; AF324701; AAG40052.1; -; mRNA. DR EMBL; AF326895; AAG41477.1; -; mRNA. DR EMBL; AF339713; AAK00395.1; -; mRNA. DR EMBL; BT000757; AAN31897.1; -; mRNA. DR PIR; D84599; D84599. DR RefSeq; NP_565505.1; NM_127700.4. DR SMR; Q9SJU9; -. DR BioGrid; 2020; 2. DR IntAct; Q9SJU9; 1. DR STRING; 3702.AT2G21280.1; -. DR iPTMnet; Q9SJU9; -. DR PaxDb; Q9SJU9; -. DR PRIDE; Q9SJU9; -. DR EnsemblPlants; AT2G21280.1; AT2G21280.1; AT2G21280. DR GeneID; 816667; -. DR Gramene; AT2G21280.1; AT2G21280.1; AT2G21280. DR KEGG; ath:AT2G21280; -. DR Araport; AT2G21280; -. DR TAIR; locus:2050090; AT2G21280. DR eggNOG; KOG3019; Eukaryota. DR eggNOG; COG1090; LUCA. DR HOGENOM; HOG000029190; -. DR InParanoid; Q9SJU9; -. DR KO; K07071; -. DR OMA; NVWNSRI; -. DR OrthoDB; 1498565at2759; -. DR PhylomeDB; Q9SJU9; -. DR PRO; PR:Q9SJU9; -. DR Proteomes; UP000006548; Chromosome 2. DR ExpressionAtlas; Q9SJU9; baseline and differential. DR Genevisible; Q9SJU9; AT. DR GO; GO:0009507; C:chloroplast; IDA:TAIR. DR GO; GO:0009941; C:chloroplast envelope; IDA:TAIR. DR GO; GO:0009706; C:chloroplast inner membrane; IEA:UniProtKB-SubCell. DR GO; GO:0009536; C:plastid; IDA:TAIR. DR GO; GO:0050662; F:coenzyme binding; IEA:InterPro. DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW. DR GO; GO:0042803; F:protein homodimerization activity; IPI:UniProtKB. DR GO; GO:0010020; P:chloroplast fission; IMP:TAIR. DR InterPro; IPR013549; DUF1731. DR InterPro; IPR001509; Epimerase_deHydtase. DR InterPro; IPR036291; NAD(P)-bd_dom_sf. DR InterPro; IPR010099; SDR39U1. DR Pfam; PF08338; DUF1731; 1. DR Pfam; PF01370; Epimerase; 1. DR SUPFAM; SSF51735; SSF51735; 1. DR TIGRFAMs; TIGR01777; yfcH; 1. PE 2: Evidence at transcript level; KW Chloroplast; Complete proteome; Membrane; NADP; Oxidoreductase; KW Plastid; Plastid inner membrane; Reference proteome; Transit peptide. FT TRANSIT 1 37 Chloroplast. {ECO:0000255}. FT CHAIN 38 347 Epimerase family protein SDR39U1 homolog, FT chloroplastic. FT /FTId=PRO_5001126579. FT NP_BIND 54 57 NADP. {ECO:0000250|UniProtKB:Q9NRG7}. FT NP_BIND 76 77 NADP. {ECO:0000250|UniProtKB:Q9NRG7}. FT NP_BIND 115 119 NADP. {ECO:0000250|UniProtKB:Q9NRG7}. FT BINDING 136 136 NADP. {ECO:0000250|UniProtKB:Q9NRG7}. SQ SEQUENCE 347 AA; 37746 MW; 0F069BFEE6D947C8 CRC64; MELLCSPTSL SSSFALSSAL LVPRSFSMPG TRRFMVLCSS QKESQMTVSV TGATGFIGRR LVQRLRADNH AIRVLTRSKS KAEQIFPAKD FPGIVIAEES EWKNCVQGST AVVNLAGLPI STRWSPEIKK EIKGSRIRVT SKVVDLINNS PAEARPTVLV SATAVGYYGT SETGVFDENS PSGKDYLAEV CREWEGTALK ANKDVRVALI RIGVVLGKDG GALAMMIPFF QMFAGGPLGS GQQWFSWIHV DDLVNLIYEA LTNPSYKGVI NGTAPNPVRL GEMCQQLGSV LSRPSWLPVP DFALKALLGE GATVVLEGQK VLPVRAKELG FEFKYKYVKD ALRAIMQ //