ID RAC6_ARATH Reviewed; 197 AA. AC Q9SBJ6; O65632; DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot. DT 31-AUG-2004, sequence version 2. DT 24-JUL-2007, entry version 49. DE Rac-like GTP-binding protein ARAC6 precursor (GTPase protein ROP5). GN Name=ARAC6; Synonyms=RAC2, ROP5; OrderedLocusNames=At4g35950; GN ORFNames=F4B14_220, T19K4.80; OS Arabidopsis thaliana (Mouse-ear cress). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons; OC rosids; eurosids II; Brassicales; Brassicaceae; Arabidopsis. OX NCBI_TaxID=3702; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY. RX PubMed=10209027; DOI=10.1083/jcb.145.2.317; RA Kost B., Lemichez E., Spielhofer P., Hong Y., Tolias K., Carpenter C., RA Chua N.-H.; RT "Rac homologues and compartmentalized phosphatidylinositol 4, 5- RT bisphosphate act in a common pathway to regulate polar pollen tube RT growth."; RL J. Cell Biol. 145:317-330(1999). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=cv. Columbia, and cv. Landsberg erecta; RX MEDLINE=20556159; PubMed=11102387; RA Winge P., Brembu T., Kristensen R., Bones A.M.; RT "Genetic structure and evolution of RAC-GTPases in Arabidopsis RT thaliana."; RL Genetics 156:1959-1971(2000). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Columbia; RX MEDLINE=20083488; PubMed=10617198; DOI=10.1038/47134; RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., RA Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., RA Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., RA Weichselgartner M., de Simone V., Obermaier B., Mache R., Mueller M., RA Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., RA Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., RA Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., RA Langham S.-A., McCullagh B., Bilham L., Robben J., RA van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., RA Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., RA Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., RA Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., RA Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., RA De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., RA van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., RA Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., RA Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., RA Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., RA Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., RA Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., RA Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., RA Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., RA Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., RA Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., RA Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., RA Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., RA Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., RA Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., RA Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., RA Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., RA Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., RA Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., RA Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., RA Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., RA Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., RA Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., RA Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., RA Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., RA Chen E., Marra M.A., Martienssen R., McCombie W.R.; RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis RT thaliana."; RL Nature 402:769-777(1999). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=cv. Columbia; RX MEDLINE=21932900; PubMed=11910074; DOI=10.1126/science.1071006; RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T., RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., RA Hayashizaki Y., Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., RA Shibata K., Shinagawa A., Shinozaki K.; RT "Functional annotation of a full-length Arabidopsis cDNA collection."; RL Science 296:141-145(2002). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=cv. Columbia; RX MEDLINE=22954850; PubMed=14593172; DOI=10.1126/science.1088305; RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., RA Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., RA Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G., RA Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., RA Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., RA Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., RA Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., RA Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., RA Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., RA Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., RA Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., RA Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.; RT "Empirical analysis of transcriptional activity in the Arabidopsis RT genome."; RL Science 302:842-846(2003). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., RA Feldmann K.A.; RT "Full-length cDNA from Arabidopsis thaliana."; RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-99, FUNCTION, AND TISSUE RP SPECIFICITY. RC STRAIN=cv. Columbia; RX MEDLINE=98440662; PubMed=9765526; DOI=10.1104/pp.118.2.407; RA Li H., Wu G., Ware D., Davis K.R., Yang Z.; RT "Arabidopsis Rho-related GTPases: differential gene expression in RT pollen and polar localization in fission yeast."; RL Plant Physiol. 118:407-417(1998). CC -!- FUNCTION: May be involved in cell polarity control during the CC actin-dependent tip growth of pollen tubes. CC -!- FUNCTION: Inactive GDP-bound Rho GTPases reside in the cytosol, CC are found in a complex with Rho GDP-dissociation inhibitors (Rho CC GDIs), and are released from the GDI protein in order to CC translocate to membranes upon activation (By similarity). CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Membrane; CC Peripheral membrane protein (By similarity). Note=Associated with CC the membrane when activated. CC -!- TISSUE SPECIFICITY: Ubiquitous. Preferentially expressed in mature CC pollen and pollen tubes. CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rho family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF107663; AAD17999.1; -; mRNA. DR EMBL; AF079487; AAC29480.1; -; mRNA. DR EMBL; AF115473; AAF40245.1; -; Genomic_DNA. DR EMBL; AL022373; CAA18489.1; -; Genomic_DNA. DR EMBL; AL031986; CAA21481.1; -; Genomic_DNA. DR EMBL; AL161588; CAB81504.1; -; Genomic_DNA. DR EMBL; AK117209; BAC41885.1; -; mRNA. DR EMBL; BT005217; AAO63281.1; -; mRNA. DR EMBL; AY087336; AAM64886.1; -; mRNA. DR EMBL; AF031429; AAB87673.1; -; Genomic_DNA. DR PIR; T04705; T04705. DR UniGene; At.2216; -. DR HSSP; P21181; 1AM4. DR GenomeReviews; CT486007_GR; AT4G35950. DR KEGG; ath:At4g35950; -. DR GeneFarm; 4164; 421. DR TAIR; At4g35950; -. DR ArrayExpress; Q9SBJ6; -. DR GermOnline; AT4G35950; Arabidopsis thaliana. DR InterPro; IPR003578; GTPase_Rho. DR InterPro; IPR013753; Ras. DR InterPro; IPR001806; Ras_trnsfrmng. DR InterPro; IPR005225; Small_GTP_bd. DR Pfam; PF00071; Ras; 1. DR PRINTS; PR00449; RASTRNSFRMNG. DR SMART; SM00174; RHO; 1. DR TIGRFAMs; TIGR00231; small_GTP; 1. PE 2: Evidence at transcript level; KW Cytoplasm; GTP-binding; Lipoprotein; Membrane; Methylation; KW Nucleotide-binding; Prenylation. FT CHAIN 1 194 Rac-like GTP-binding protein ARAC6. FT /FTId=PRO_0000198920. FT PROPEP 195 197 Removed in mature form (Potential). FT /FTId=PRO_0000227585. FT NP_BIND 13 20 GTP (By similarity). FT NP_BIND 60 64 GTP (By similarity). FT NP_BIND 118 121 GTP (By similarity). FT MOTIF 35 43 Effector region (Potential). FT COMPBIAS 182 189 Poly-Lys. FT MOD_RES 194 194 Cysteine methyl ester (Potential). FT LIPID 194 194 S-geranylgeranyl cysteine (Potential). SQ SEQUENCE 197 AA; 21571 MW; D26BE6D3827C1632 CRC64; MSASRFIKCV TVGDGAVGKT CLLISYTSNT FPTDYVPTVF DNFSANVVVN GATVNLGLWD TAGQEDYNRL RPLSYRGADV FILAFSLISK ASYENVSKKW IPELKHYAPG VPIVLVGTKL DLRDDKQFFI DHPGAVPITT VQGEELKKLI GAPAYIECSS KSQENVKGVF DAAIRVVLQP PKQKKKKNKA QKACSIL //