ID PRC9_MOUSE STANDARD; PRT; 261 AA. AC Q9R1P0; DT 01-OCT-2000 (Rel. 40, Created) DT 01-OCT-2000 (Rel. 40, Last sequence update) DT 01-OCT-2000 (Rel. 40, Last annotation update) DE PROTEASOME COMPONENT C9 (EC 3.4.99.46) (MACROPAIN SUBUNIT C9) DE (MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT C9). GN PSMA4. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=B10.BR; RX MEDLINE=99367391; PubMed=10436176; RA Elenich L.A., Nandi D., Kent E.A., McCluskey T.S., Cruz M., Iyer M.N., RA Woodward E.C., Conn C.W., Ochoa A.L., Ginsburg D.B., Monaco J.J.; RT "The complete primary structure of mouse 20S proteasomes."; RL Immunogenetics 49:835-842(1999). CC -!- FUNCTION: THE PROTEASOME IS A MULTICATALYTIC PROTEINASE COMPLEX CC WHICH IS CHARACTERIZED BY ITS ABILITY TO CLEAVE PEPTIDES WITH CC ARG, PHE, TYR, LEU, AND GLU ADJACENT TO THE LEAVING GROUP AT CC NEUTRAL OR SLIGHTLY BASIC PH. THE PROTEASOME HAS AN ATP-DEPENDENT CC PROTEOLYTIC ACTIVITY. CC -!- PATHWAY: IS INVOLVED IN AN ATP/UBIQUITIN-DEPENDENT NON-LYSOSOMAL CC PROTEOLYTIC PATHWAY. CC -!- SUBUNIT: THE PROTEASOME IS COMPOSED OF AT LEAST 15 NON IDENTICAL CC SUBUNITS WHICH FORM A HIGHLY ORDERED RING-SHAPED STRUCTURE. CC -!- SUBCELLULAR LOCATION: PROTEASOMES ARE FOUND IN THE CYTOPLASM AND CC ALSO IN THE NUCLEUS. CC -!- SIMILARITY: BELONGS TO PEPTIDASE FAMILY T1A; ALSO KNOWN AS THE CC PROTEASOME A-TYPE FAMILY. C9 SUBFAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF060093; AAD50538.1; -. DR MGD; MGI:1347060; PSMA4. DR INTERPRO; IPR000426; -. DR INTERPRO; IPR001353; -. DR PFAM; PF00227; proteasome; 1. DR PROSITE; PS00388; PROTEASOME_A; 1. KW Proteasome; Hydrolase; Protease. SQ SEQUENCE 261 AA; 29471 MW; BB7CC8113791E13B CRC64; MSRRYDSRTT IFSPEGRLYQ VEYAMEAIGH AGTCLGILAN DGVLLAAERR NIHKLLDEVF FSEKIYKLNE DMACSVAGIT SDANVLTNEL RLIAQRYLLQ YQEPIPCEQL VTALCDIKQA YTQFGGKRPF GVSLLYIGWD KHYGFQLYQS DPSGNYGGWK ATCIGNNSAA AVSMLKQDYK EGEMTLKSAL ALAVKVLNKT MDVSKLSAEK VEIATLTRES GKTVIRVLKQ KEVEQLIKKH EEEEAKAERE KKEKEQREKD K //