ID Q9R0T7_MOUSE Unreviewed; 246 AA. AC Q9R0T7; DT 01-MAY-2000, integrated into UniProtKB/TrEMBL. DT 01-MAY-2000, sequence version 1. DT 22-FEB-2012, entry version 86. DE SubName: Full=MCG15085; DE SubName: Full=Pancreatic trypsin; DE SubName: Full=Trypsin 4; DE SubName: Full=Trypsinogen 8; DE SubName: Full=Uncharacterized protein; GN Name=Try4; Synonyms=trypsinogen; ORFNames=mCG_15085; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Spleen, and Stomach; RX PubMed=16141073; DOI=10.1126/science.1112009; RG RIKEN Genome Exploration Research Group and Genome Science Group RG (Genome Network Project Core Group) and the FANTOM Consortium; RT "Antisense Transcription in the Mammalian Transcriptome."; RL Science 309:1564-1566(2005). RN [2] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Spleen, and Stomach; RX MEDLINE=20530913; PubMed=11076861; DOI=10.1101/gr.152600; RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., RA Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., RA Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., RA Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., RA Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., RA Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.; RT "RIKEN integrated sequence analysis (RISA) system--384-format RT sequencing pipeline with 384 multicapillary sequencer."; RL Genome Res. 10:1757-1771(2000). RN [3] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed; RX MEDLINE=22036378; PubMed=12040188; DOI=10.1126/science.1069193; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., RA Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., RA Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W., RA Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., RA Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., RA Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., RA Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., RA Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., RA Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., RA Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., RA Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., RA Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., RA Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., RA Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., RA Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., RA Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., RA Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., RA Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., RA Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., RA Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., RA Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., RA Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., RA Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., RA Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., RA Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., RA Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., RA Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., RA Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., RA Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., RA Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., RA Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., RA Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.; RT "A comparison of whole-genome shotgun-derived mouse chromosome 16 and RT the human genome."; RL Science 296:1661-1671(2002). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RG Mouse Genome Sequencing Consortium; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [5] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Spleen, and Stomach; RG The RIKEN Genome Exploration Research Group Phase II Team and the RG FANTOM Consortium; RT "Functional annotation of a full-length mouse cDNA collection."; RL Nature 409:685-690(2001). RN [6] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Spleen, and Stomach; RX MEDLINE=99279253; PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9; RA Carninci P., Hayashizaki Y.; RT "High-efficiency full-length cDNA cloning."; RL Methods Enzymol. 303:19-44(1999). RN [7] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Spleen, and Stomach; RX MEDLINE=20499374; PubMed=11042159; DOI=10.1101/gr.145100; RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.; RT "Normalization and subtraction of cap-trapper-selected cDNAs to RT prepare full-length cDNA libraries for rapid discovery of new genes."; RL Genome Res. 10:1617-1630(2000). RN [8] RP NUCLEOTIDE SEQUENCE. RC STRAIN=129SVJ; RX MEDLINE=99436155; PubMed=10506205; DOI=10.1074/jbc.274.41.29426; RA Ohmura K., Kohno N., Kobayashi Y., Yamagata K., Sato S., RA Kashiwabara S., Baba T.; RT "A homologue of pancreatic trypsin is localized in the acrosome of RT mammalian sperm and is released during acrosome reaction."; RL J. Biol. Chem. 274:29426-29432(1999). RN [9] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Spleen, and Stomach; RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group RG Phase I and II Team; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). RN [10] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Spleen, and Stomach; RG The FANTOM Consortium, Riken Genome Exploration Research Group and RG Genome Science Group (Genome Network Project Core Group); RT "The Transcriptional Landscape of the Mammalian Genome."; RL Science 309:1559-1563(2005). RN [11] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=21103195; PubMed=11160223; RA Chen F., Rowen L., Hood L., Rothenberg E.V.; RT "Differential transcriptional regulation of individual TCR V beta RT segments before gene rearrangement."; RL J. Immunol. 166:1771-1780(2001). RN [12] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Liver; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [13] RP IDENTIFICATION. RC STRAIN=C57BL/6J; RG Ensembl; RL Submitted (JUN-2011) to UniProtKB. RN [14] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Spleen, and Stomach; RA Adachi J., Aizawa K., Akahira S., Akimura T., Arai A., Aono H., RA Arakawa T., Bono H., Carninci P., Fukuda S., Fukunishi Y., Furuno M., RA Hanagaki T., Hara A., Hayatsu N., Hiramoto K., Hiraoka T., Hori F., RA Imotani K., Ishii Y., Itoh M., Izawa M., Kasukawa T., Kato H., RA Kawai J., Kojima Y., Konno H., Kouda M., Koya S., Kurihara C., RA Matsuyama T., Miyazaki A., Nishi K., Nomura K., Numazaki R., Ohno M., RA Okazaki Y., Okido T., Owa C., Saito H., Saito R., Sakai C., Sakai K., RA Sano H., Sasaki D., Shibata K., Shibata Y., Shinagawa A., Shiraki T., RA Sogabe Y., Suzuki H., Tagami M., Tagawa A., Takahashi F., Tanaka T., RA Tejima Y., Toya T., Yamamura T., Yasunishi A., Yoshida K., Yoshino M., RA Muramatsu M., Hayashizaki Y.; RL Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases. RN [15] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the peptidase S1 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC125228; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AE000664; AAB69056.1; -; Genomic_DNA. DR EMBL; BC061135; AAH61135.1; -; mRNA. DR EMBL; AB017032; BAA74761.1; -; Genomic_DNA. DR EMBL; AK003064; BAB22542.1; -; mRNA. DR EMBL; AK008667; BAB25821.1; -; mRNA. DR EMBL; CH466533; EDL13537.1; -; Genomic_DNA. DR IPI; IPI00128108; -. DR RefSeq; NP_035776.1; NM_011646.5. DR UniGene; Mm.383263; -. DR HSSP; P00763; 1SLU. DR ProteinModelPortal; Q9R0T7; -. DR SMR; Q9R0T7; 24-246. DR STRING; Q9R0T7; -. DR MEROPS; S01.057; -. DR PRIDE; Q9R0T7; -. DR Ensembl; ENSMUST00000031913; ENSMUSP00000031913; ENSMUSG00000054106. DR GeneID; 22074; -. DR KEGG; mmu:22074; -. DR UCSC; uc009bou.2; mouse. DR CTD; 22074; -. DR MGI; MGI:102757; Try4. DR GeneTree; ENSGT00580000081320; -. DR HOGENOM; HBG755338; -. DR HOVERGEN; HBG013304; -. DR InParanoid; Q9R0T7; -. DR OrthoDB; EOG4SJ5FV; -. DR PhylomeDB; Q9R0T7; -. DR NextBio; 301910; -. DR ArrayExpress; Q9R0T7; -. DR Bgee; Q9R0T7; -. DR Genevestigator; Q9R0T7; -. DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW. DR InterPro; IPR009003; Pept_cys/ser_Trypsin-like. DR InterPro; IPR018114; Peptidase_S1/S6_AS. DR InterPro; IPR001254; Peptidase_S1_S6. DR InterPro; IPR001314; Peptidase_S1A. DR Pfam; PF00089; Trypsin; 1. DR PRINTS; PR00722; CHYMOTRYPSIN. DR SMART; SM00020; Tryp_SPc; 1. DR SUPFAM; SSF50494; Pept_Ser_Cys; 1. DR PROSITE; PS50240; TRYPSIN_DOM; 1. DR PROSITE; PS00134; TRYPSIN_HIS; 1. DR PROSITE; PS00135; TRYPSIN_SER; 1. PE 2: Evidence at transcript level; KW Complete proteome; Hydrolase; Protease; Reference proteome; KW Serine protease. SQ SEQUENCE 246 AA; 26274 MW; B6A9F4C99079633F CRC64; MRALLFLALV GAAVAFPVDD DDKIVGGYTC RENSVPYQVS LNSGYHFCGG SLINDQWVVS AAHCYKSRIQ VRLGEHNINV LEGNEQFVNS AKIIKHPNFN SRTLNNDIML IKLASPVTLN ARVATVALPS SCAPAGTQCL ISGWGNTLSF GVNNPDLLQC LDAPLLPQAD CEASYPGKIT NNMICVGFLE GGKDSCQGDS GGPVVCNGQL QGIVSWGYGC ALKDNPGVYT KVCNYVDWIQ NTIAAN //