ID KIME_MOUSE STANDARD; PRT; 395 AA. AC Q9R008; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Mevalonate kinase (EC 2.7.1.36) (MK). GN MVK. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=99330561; PubMed=10401001; RA Houten S.M., Romeijn G.J., Koster J., Gray R.G.F., Darbyshire P., RA Smit G.P.A., de Klerk J.B.C., Duran R., Gibson K.M., Wanders R.J.A., RA Waterham H.R.; RT "Identification and characterization of three novel missense mutations RT in mevalonate kinase cDNA causing mevalonic aciduria, a disorder of RT isoprene biosynthesis."; RL Hum. Mol. Genet. 8:1523-1528(1999). RN [2] RP SEQUENCE FROM N.A. RC STRAIN=FVB/N; TISSUE=Mammary gland; RX MEDLINE=22388257; PubMed=12477932; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length RT human and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). CC -!- FUNCTION: May be a regulatory site in cholesterol biosynthetic CC pathway. CC -!- CATALYTIC ACTIVITY: ATP + (R)-mevalonate = ADP + (R)-5- CC phosphomevalonate. CC -!- ENZYME REGULATION: Farnesyl- and geranyl-pyrophosphates are CC competitive inhibitors (By similarity). CC -!- PATHWAY: Cholesterol biosynthesis, mevalonate catabolism. CC -!- SUBUNIT: Homodimer (By similarity). CC -!- SUBCELLULAR LOCATION: Cytoplasmic and peroxisomal. CC -!- SIMILARITY: Belongs to the GHMP kinase family. Mevalonate kinase CC subfamily. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF137598; AAF00700.1; -. DR EMBL; BC005606; AAH05606.1; -. DR HSSP; P17256; 1KVK. DR MGD; MGI:107624; Mvk. DR GO; GO:0004496; F:mevalonate kinase activity; IDA. DR InterPro; IPR001174; Galkinase. DR InterPro; IPR006204; GHMP_kinase. DR InterPro; IPR006203; GHMPknse_ATP. DR InterPro; IPR006205; Mev_gal_kin. DR InterPro; IPR006206; Mev_galkinase. DR Pfam; PF00288; GHMP_kinases; 1. DR PRINTS; PR00959; MEVGALKINASE. DR TIGRFAMs; TIGR00549; mevalon_kin; 1. DR PROSITE; PS00627; GHMP_KINASES_ATP; 1. KW Transferase; Kinase; Cholesterol biosynthesis; ATP-binding; KW Peroxisome. FT NP_BIND 138 148 ATP (Potential). SQ SEQUENCE 395 AA; 41877 MW; 953DB1C89403A3F8 CRC64; MLSEALLVSA PGKVILHGEH AVVHGKVALA AALNLRTFLL LRPQSNGKVS VNLPNIGIKQ VWDVGMLQRL DTSFLEQGDV SVPTLEQLEK LKKMGDLPRD RAGNEGMALL AFLYLYLAIC RKQRTLPSLD MVVWSELPPG AGLGSSAAYS VCLAAALLTA CEEVSNPLKD GVSVSRWPEE DLKSINKWAF EGERVIHGNP SGVDNAVSTW GGALRFQQGT MSSLKSLPSL QILLTNTKVP RSTKALVAAV RSRLTKFPEI VAPLLTSIDA ISLECERVLG EMVAAPVPEQ YLVLEELIDM NQHHLNALGV GHNSLDQLCQ VTAAHGLHSK LTGAGGGGCG ITLLKPGLEQ ATVEAAKQAL TSCGFDCWET SIGAPGVSTH SAAAVGDPVR QALGL //