ID KIME_MOUSE Reviewed; 395 AA. AC Q9R008; DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-2000, sequence version 1. DT 13-NOV-2013, entry version 107. DE RecName: Full=Mevalonate kinase; DE Short=MK; DE EC=2.7.1.36; GN Name=Mvk; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=10401001; DOI=10.1093/hmg/8.8.1523; RA Houten S.M., Romeijn G.J., Koster J., Gray R.G.F., Darbyshire P., RA Smit G.P.A., de Klerk J.B.C., Duran R., Gibson K.M., Wanders R.J.A., RA Waterham H.R.; RT "Identification and characterization of three novel missense mutations RT in mevalonate kinase cDNA causing mevalonic aciduria, a disorder of RT isoprene biosynthesis."; RL Hum. Mol. Genet. 8:1523-1528(1999). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=FVB/N; TISSUE=Mammary gland; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: May be a regulatory site in cholesterol biosynthetic CC pathway. CC -!- CATALYTIC ACTIVITY: ATP + (R)-mevalonate = ADP + (R)-5- CC phosphomevalonate. CC -!- ENZYME REGULATION: Farnesyl- and geranyl-pyrophosphates are CC competitive inhibitors (By similarity). CC -!- PATHWAY: Isoprenoid biosynthesis; isopentenyl diphosphate CC biosynthesis via mevalonate pathway; isopentenyl diphosphate from CC (R)-mevalonate: step 1/3. CC -!- SUBUNIT: Homodimer (By similarity). CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). CC -!- SIMILARITY: Belongs to the GHMP kinase family. Mevalonate kinase CC subfamily. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF137598; AAF00700.1; -; mRNA. DR EMBL; BC005606; AAH05606.1; -; mRNA. DR IPI; IPI00756996; -. DR RefSeq; NP_076045.1; NM_023556.2. DR UniGene; Mm.28088; -. DR ProteinModelPortal; Q9R008; -. DR SMR; Q9R008; 1-395. DR IntAct; Q9R008; 1. DR MINT; MINT-4099820; -. DR PhosphoSite; Q9R008; -. DR PaxDb; Q9R008; -. DR PRIDE; Q9R008; -. DR Ensembl; ENSMUST00000043760; ENSMUSP00000036971; ENSMUSG00000041939. DR GeneID; 17855; -. DR KEGG; mmu:17855; -. DR UCSC; uc008yzq.1; mouse. DR CTD; 4598; -. DR MGI; MGI:107624; Mvk. DR eggNOG; COG1577; -. DR GeneTree; ENSGT00390000011860; -. DR HOGENOM; HOG000188934; -. DR HOVERGEN; HBG000402; -. DR KO; K00869; -. DR OrthoDB; EOG7G1V6N; -. DR UniPathway; UPA00057; UER00098. DR NextBio; 292601; -. DR PRO; PR:Q9R008; -. DR ArrayExpress; Q9R008; -. DR Bgee; Q9R008; -. DR CleanEx; MM_MVK; -. DR Genevestigator; Q9R008; -. DR GO; GO:0005829; C:cytosol; IEA:Ensembl. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0004496; F:mevalonate kinase activity; IDA:MGI. DR GO; GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW. DR GO; GO:0019287; P:isopentenyl diphosphate biosynthetic process, mevalonate pathway; IEA:UniProtKB-UniPathway. DR GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl. DR Gene3D; 3.30.230.10; -; 1. DR InterPro; IPR013750; GHMP_kinase_C_dom. DR InterPro; IPR006204; GHMP_kinase_N_dom. DR InterPro; IPR006203; GHMP_knse_ATP-bd_CS. DR InterPro; IPR006205; Mev_gal_kin. DR InterPro; IPR006206; Mevalonate/galactokinase. DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold. DR InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr. DR PANTHER; PTHR10457:SF4; PTHR10457:SF4; 1. DR Pfam; PF08544; GHMP_kinases_C; 1. DR Pfam; PF00288; GHMP_kinases_N; 1. DR PRINTS; PR00959; MEVGALKINASE. DR SUPFAM; SSF54211; SSF54211; 1. DR TIGRFAMs; TIGR00549; mevalon_kin; 1. DR PROSITE; PS00627; GHMP_KINASES_ATP; 1. PE 2: Evidence at transcript level; KW ATP-binding; Cholesterol biosynthesis; Cholesterol metabolism; KW Complete proteome; Cytoplasm; Kinase; Lipid biosynthesis; KW Lipid metabolism; Nucleotide-binding; Reference proteome; KW Steroid biosynthesis; Steroid metabolism; Sterol biosynthesis; KW Sterol metabolism; Transferase. FT CHAIN 1 395 Mevalonate kinase. FT /FTId=PRO_0000156658. FT NP_BIND 138 148 ATP (By similarity). FT BINDING 55 55 ATP (By similarity). FT BINDING 135 135 ATP (By similarity). SQ SEQUENCE 395 AA; 41877 MW; 953DB1C89403A3F8 CRC64; MLSEALLVSA PGKVILHGEH AVVHGKVALA AALNLRTFLL LRPQSNGKVS VNLPNIGIKQ VWDVGMLQRL DTSFLEQGDV SVPTLEQLEK LKKMGDLPRD RAGNEGMALL AFLYLYLAIC RKQRTLPSLD MVVWSELPPG AGLGSSAAYS VCLAAALLTA CEEVSNPLKD GVSVSRWPEE DLKSINKWAF EGERVIHGNP SGVDNAVSTW GGALRFQQGT MSSLKSLPSL QILLTNTKVP RSTKALVAAV RSRLTKFPEI VAPLLTSIDA ISLECERVLG EMVAAPVPEQ YLVLEELIDM NQHHLNALGV GHNSLDQLCQ VTAAHGLHSK LTGAGGGGCG ITLLKPGLEQ ATVEAAKQAL TSCGFDCWET SIGAPGVSTH SAAAVGDPVR QALGL //