ID BCL10_RAT Reviewed; 233 AA. AC Q9QYN5; DT 02-MAY-2002, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-2000, sequence version 1. DT 09-JAN-2013, entry version 82. DE RecName: Full=B-cell lymphoma/leukemia 10; DE AltName: Full=B-cell CLL/lymphoma 10; DE Short=Bcl-10; DE AltName: Full=R-RCD1; DE Short=RCD; GN Name=Bcl10; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Embryonic brain; RX MEDLINE=20219157; PubMed=10753917; DOI=10.1074/jbc.275.15.11114; RA Yoneda T., Imaizumi K., Maeda M., Yui D., Manabe T., Katayama T., RA Sato N., Gomi F., Morihara T., Mori Y., Miyoshi K., Hitomi J., RA Ugawa S., Yamada S., Okabe M., Tohyama M.; RT "Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, RT a MALT lymphoma-associated protein."; RL J. Biol. Chem. 275:11114-11120(2000). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Prostate; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Promotes apoptosis, pro-caspase-9 maturation and CC activation of NF-kappa-B via NIK and IKK. May be an adapter CC protein between upstream TNFR1-TRADD-RIP complex and the CC downstream NIK-IKK-IKAP complex (By similarity). Is a substrate CC for MALT1 (By similarity). CC -!- SUBUNIT: Found in a membrane raft complex, at least composed of CC BCL10, CARD11, DPP4 and IKBKB. Self-associates by CARD-CARD CC interaction and interacts with other CARD-proteins such as CARD9, CC CARD10, CARD11 and CARD14. Binds caspase-9 with its C-terminal CC domain (By similarity). Interacts with TRAF2 and BIRC2/c-IAP2. CC Interacts with PELI2 and SOCS3; these interactions may be mutually CC exclusive (By similarity). CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Membrane raft (By CC similarity). Note=Colocalized with DPP4 in membrane rafts (By CC similarity). CC -!- PTM: Phosphorylated by IKBKB/IKKB (By similarity). CC -!- SIMILARITY: Contains 1 CARD domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB016069; BAA88822.1; -; mRNA. DR EMBL; BC061772; AAH61772.1; -; mRNA. DR IPI; IPI00214295; -. DR RefSeq; NP_112618.1; NM_031328.1. DR UniGene; Rn.13007; -. DR ProteinModelPortal; Q9QYN5; -. DR STRING; Q9QYN5; -. DR PhosphoSite; Q9QYN5; -. DR GeneID; 83477; -. DR KEGG; rno:83477; -. DR CTD; 8915; -. DR RGD; 620544; Bcl10. DR eggNOG; NOG44778; -. DR HOGENOM; HOG000008671; -. DR HOVERGEN; HBG050680; -. DR KO; K07368; -. DR OrthoDB; EOG41JZD7; -. DR NextBio; 615897; -. DR ArrayExpress; Q9QYN5; -. DR Genevestigator; Q9QYN5; -. DR GermOnline; ENSRNOG00000014613; Rattus norvegicus. DR GO; GO:0005829; C:cytosol; ISS:UniProtKB. DR GO; GO:0001772; C:immunological synapse; IEA:Compara. DR GO; GO:0046696; C:lipopolysaccharide receptor complex; IEA:Compara. DR GO; GO:0005764; C:lysosome; ISS:UniProtKB. DR GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell. DR GO; GO:0005634; C:nucleus; ISS:UniProtKB. DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB. DR GO; GO:0043234; C:protein complex; ISS:UniProtKB. DR GO; GO:0042101; C:T cell receptor complex; IEA:Compara. DR GO; GO:0019209; F:kinase activator activity; IEA:Compara. DR GO; GO:0051059; F:NF-kappaB binding; ISS:UniProtKB. DR GO; GO:0008022; F:protein C-terminus binding; ISS:UniProtKB. DR GO; GO:0043422; F:protein kinase B binding; ISS:UniProtKB. DR GO; GO:0043621; F:protein self-association; ISS:UniProtKB. DR GO; GO:0003713; F:transcription coactivator activity; ISS:UniProtKB. DR GO; GO:0043130; F:ubiquitin binding; ISS:UniProtKB. DR GO; GO:0031625; F:ubiquitin protein ligase binding; ISS:UniProtKB. DR GO; GO:0006915; P:apoptotic process; ISS:UniProtKB. DR GO; GO:0006968; P:cellular defense response; IEA:Compara. DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Compara. DR GO; GO:0016064; P:immunoglobulin mediated immune response; IEA:Compara. DR GO; GO:0006917; P:induction of apoptosis; IDA:RGD. DR GO; GO:0045087; P:innate immune response; ISS:UniProtKB. DR GO; GO:0002906; P:negative regulation of mature B cell apoptotic process; ISS:UniProtKB. DR GO; GO:0001843; P:neural tube closure; ISS:UniProtKB. DR GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; ISS:UniProtKB. DR GO; GO:0045416; P:positive regulation of interleukin-8 biosynthetic process; ISS:UniProtKB. DR GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB. DR GO; GO:0042327; P:positive regulation of phosphorylation; ISS:UniProtKB. DR GO; GO:0031398; P:positive regulation of protein ubiquitination; ISS:UniProtKB. DR GO; GO:0050870; P:positive regulation of T cell activation; IEA:Compara. DR GO; GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB. DR GO; GO:0051291; P:protein heterooligomerization; IPI:RGD. DR GO; GO:0051260; P:protein homooligomerization; ISS:UniProtKB. DR GO; GO:0050856; P:regulation of T cell receptor signaling pathway; IEA:Compara. DR GO; GO:0009620; P:response to fungus; IEA:Compara. DR GO; GO:0002237; P:response to molecule of bacterial origin; ISS:UniProtKB. DR GO; GO:0050852; P:T cell receptor signaling pathway; ISS:UniProtKB. DR Gene3D; 1.10.533.10; DEATH_like; 1. DR InterPro; IPR001315; CARD. DR InterPro; IPR011029; DEATH-like. DR Pfam; PF00619; CARD; 1. DR SUPFAM; SSF47986; DEATH_like; 1. DR PROSITE; PS50209; CARD; 1. PE 2: Evidence at transcript level; KW Acetylation; Apoptosis; Complete proteome; Cytoplasm; Membrane; KW Phosphoprotein; Reference proteome; Tumor suppressor. FT CHAIN 1 233 B-cell lymphoma/leukemia 10. FT /FTId=PRO_0000144076. FT DOMAIN 13 101 CARD. FT MOD_RES 1 1 N-acetylmethionine (By similarity). SQ SEQUENCE 233 AA; 25999 MW; B43274B4B825FC7D CRC64; MEAPAPSLTE EDLTEVKKDA LENLRVYLCE KIIAERHFDH LRAKKILSRE DTEEISCRTS SRKRAGKLLD YLQENPKGLD TLVESIRREK TQNFLIQKIT DEVLKLRNIK LEHLKGLKCS SCEPFAAGAT NNLSRSNSDE SNFSEKQRPS TVIYHPEGES STAPFFSTES SLNLPVLEVG RLENSSFSSA SLPRPGDPGA PPLPPDLRLE EGGSCGNSSE MFLPLRSRAL SRQ //