ID BCLA_RAT STANDARD; PRT; 233 AA. AC Q9QYN5; DT 01-MAR-2002 (Rel. 41, Created) DT 01-MAR-2002 (Rel. 41, Last sequence update) DT 01-MAR-2002 (Rel. 41, Last annotation update) DE B cell lymphoma/leukemia 10 (B-cell CLL/lymphoma 10) (Bcl-10) (R- DE RCD1) (RCD). GN BCL10. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Embryonic brain; RX MEDLINE=20219157; PubMed=10753917; RA Yoneda T., Imaizumi K., Maeda M., Yui D., Manabe T., Katayama T., RA Sato N., Gomi F., Morihara T., Mori Y., Miyoshi K., Hitomi J., RA Ugawa S., Yamada S., Okabe M., Tohyama M.; RT "Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, RT a MALT lymphoma-associated protein."; RL J. Biol. Chem. 275:11114-11120(2000). CC -!- FUNCTION: Promotes apoptosis, pro-caspase-9 maturation and CC activation of NF-kappaB via NIK and IKK. May be an adapter protein CC between upstream TNFR1-TRADD-RIP complex and the downstream NIK- CC IKK-IKAP complex (By similarity). CC -!- SUBUNIT: Self-associates by CARD-CARD interaction and interacts CC with other CARD-proteins such as CARD9, CARD10, CARD11 and CARD14. CC Binds caspase-9 with its C-terminal domain (By similarity). CC Interacts with TRAF2 and BIRC2/c-IAP2. CC -!- SUBCELLULAR LOCATION: Cytoplasmic (By similarity). CC -!- PTM: Phosphorylated (By similarity). CC -!- SIMILARITY: Contains 1 CARD domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB016069; BAA88822.1; -. DR InterPro; IPR001315; CARD. DR Pfam; PF00619; CARD; 1. DR SMART; SM00114; CARD; 1. DR PROSITE; PS50209; CARD; 1. KW Apoptosis; Anti-oncogene; Phosphorylation. FT DOMAIN 13 101 CARD. SQ SEQUENCE 233 AA; 25999 MW; B43274B4B825FC7D CRC64; MEAPAPSLTE EDLTEVKKDA LENLRVYLCE KIIAERHFDH LRAKKILSRE DTEEISCRTS SRKRAGKLLD YLQENPKGLD TLVESIRREK TQNFLIQKIT DEVLKLRNIK LEHLKGLKCS SCEPFAAGAT NNLSRSNSDE SNFSEKQRPS TVIYHPEGES STAPFFSTES SLNLPVLEVG RLENSSFSSA SLPRPGDPGA PPLPPDLRLE EGGSCGNSSE MFLPLRSRAL SRQ //