ID BCL10_RAT Reviewed; 233 AA. AC Q9QYN5; DT 02-MAY-2002, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-2000, sequence version 1. DT 25-NOV-2008, entry version 48. DE RecName: Full=B-cell lymphoma/leukemia 10; DE AltName: Full=B-cell CLL/lymphoma 10; DE Short=Bcl-10; DE AltName: Full=R-RCD1; DE Short=RCD; GN Name=Bcl10; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Embryonic brain; RX MEDLINE=20219157; PubMed=10753917; DOI=10.1074/jbc.275.15.11114; RA Yoneda T., Imaizumi K., Maeda M., Yui D., Manabe T., Katayama T., RA Sato N., Gomi F., Morihara T., Mori Y., Miyoshi K., Hitomi J., RA Ugawa S., Yamada S., Okabe M., Tohyama M.; RT "Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, RT a MALT lymphoma-associated protein."; RL J. Biol. Chem. 275:11114-11120(2000). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Prostate; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Promotes apoptosis, pro-caspase-9 maturation and CC activation of NF-kappa-B via NIK and IKK. May be an adapter CC protein between upstream TNFR1-TRADD-RIP complex and the CC downstream NIK-IKK-IKAP complex (By similarity). Is a substrate CC for MALT1 (By similarity). CC -!- SUBUNIT: Self-associates by CARD-CARD interaction and interacts CC with other CARD-proteins such as CARD9, CARD10, CARD11 and CARD14. CC Binds caspase-9 with its C-terminal domain (By similarity). CC Interacts with TRAF2 and BIRC2/c-IAP2. CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). CC -!- PTM: Phosphorylated (By similarity). CC -!- SIMILARITY: Contains 1 CARD domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB016069; BAA88822.1; -; mRNA. DR EMBL; BC061772; AAH61772.1; -; mRNA. DR RefSeq; NP_112618.1; -. DR UniGene; Rn.13007; -. DR Ensembl; ENSRNOG00000014613; Rattus norvegicus. DR GeneID; 83477; -. DR KEGG; rno:83477; -. DR RGD; 620544; Bcl10. DR HOVERGEN; Q9QYN5; -. DR NextBio; 615897; -. DR ArrayExpress; Q9QYN5; -. DR GermOnline; ENSRNOG00000014613; Rattus norvegicus. DR GO; GO:0005829; C:cytosol; ISS:UniProtKB. DR GO; GO:0005764; C:lysosome; ISS:UniProtKB. DR GO; GO:0005634; C:nucleus; ISS:UniProtKB. DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB. DR GO; GO:0043234; C:protein complex; ISS:UniProtKB. DR GO; GO:0051059; F:NF-kappaB binding; ISS:UniProtKB. DR GO; GO:0008022; F:protein C-terminus binding; ISS:UniProtKB. DR GO; GO:0043422; F:protein kinase B binding; ISS:UniProtKB. DR GO; GO:0043621; F:protein self-association; ISS:UniProtKB. DR GO; GO:0003713; F:transcription coactivator activity; ISS:UniProtKB. DR GO; GO:0043130; F:ubiquitin binding; ISS:UniProtKB. DR GO; GO:0031625; F:ubiquitin protein ligase binding; ISS:UniProtKB. DR GO; GO:0045087; P:innate immune response; ISS:UniProtKB. DR GO; GO:0045786; P:negative regulation of cell cycle; IEA:UniProtKB-KW. DR GO; GO:0002906; P:negative regulation of mature B cell apoptosis; ISS:UniProtKB. DR GO; GO:0001843; P:neural tube closure; ISS:UniProtKB. DR GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-k...; ISS:UniProtKB. DR GO; GO:0045416; P:positive regulation of interleukin-8 biosyn...; ISS:UniProtKB. DR GO; GO:0051092; P:positive regulation of NF-kappaB transcript...; ISS:UniProtKB. DR GO; GO:0042327; P:positive regulation of phosphorylation; ISS:UniProtKB. DR GO; GO:0031398; P:positive regulation of protein ubiquitination; ISS:UniProtKB. DR GO; GO:0045893; P:positive regulation of transcription, DNA-d...; ISS:UniProtKB. DR GO; GO:0051260; P:protein homooligomerization; ISS:UniProtKB. DR GO; GO:0002237; P:response to molecule of bacterial origin; ISS:UniProtKB. DR GO; GO:0050852; P:T cell receptor signaling pathway; ISS:UniProtKB. DR InterPro; IPR001315; CARD. DR InterPro; IPR011029; DEATH_like. DR Gene3D; G3DSA:1.10.533.10; DEATH_like; 1. DR Pfam; PF00619; CARD; 1. DR PROSITE; PS50209; CARD; 1. PE 2: Evidence at transcript level; KW Anti-oncogene; Apoptosis; Cell cycle; Cytoplasm; Phosphoprotein. FT CHAIN 1 233 B-cell lymphoma/leukemia 10. FT /FTId=PRO_0000144076. FT DOMAIN 13 101 CARD. SQ SEQUENCE 233 AA; 25999 MW; B43274B4B825FC7D CRC64; MEAPAPSLTE EDLTEVKKDA LENLRVYLCE KIIAERHFDH LRAKKILSRE DTEEISCRTS SRKRAGKLLD YLQENPKGLD TLVESIRREK TQNFLIQKIT DEVLKLRNIK LEHLKGLKCS SCEPFAAGAT NNLSRSNSDE SNFSEKQRPS TVIYHPEGES STAPFFSTES SLNLPVLEVG RLENSSFSSA SLPRPGDPGA PPLPPDLRLE EGGSCGNSSE MFLPLRSRAL SRQ //