ID BCL10_RAT Reviewed; 233 AA. AC Q9QYN5; DT 02-MAY-2002, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-2000, sequence version 1. DT 07-OCT-2020, entry version 133. DE RecName: Full=B-cell lymphoma/leukemia 10; DE AltName: Full=B-cell CLL/lymphoma 10; DE Short=Bcl-10; DE AltName: Full=R-RCD1; DE Short=RCD; GN Name=Bcl10; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Embryonic brain; RX PubMed=10753917; DOI=10.1074/jbc.275.15.11114; RA Yoneda T., Imaizumi K., Maeda M., Yui D., Manabe T., Katayama T., Sato N., RA Gomi F., Morihara T., Mori Y., Miyoshi K., Hitomi J., Ugawa S., Yamada S., RA Okabe M., Tohyama M.; RT "Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a RT MALT lymphoma-associated protein."; RL J. Biol. Chem. 275:11114-11120(2000). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Prostate; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Involved in adaptive immune response. Promotes apoptosis, CC pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. CC May be an adapter protein between upstream TNFR1-TRADD-RIP complex and CC the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1. CC {ECO:0000250|UniProtKB:O95999}. CC -!- SUBUNIT: Found in a membrane raft complex, at least composed of BCL10, CC CARD11, DPP4 and IKBKB. Self-associates by CARD-CARD interaction and CC interacts with other CARD-proteins such as CARD9, CARD10, CARD11 and CC CARD14. Forms a complex with CARD14 and MALT1; resulting in the CC formation of a CBM (CARD14-BCL10-MALT1) complex. Binds caspase-9 with CC its C-terminal domain (By similarity). Interacts with TRAF2 and CC BIRC2/c-IAP2. Interacts with PELI2 and SOCS3; these interactions may be CC mutually exclusive (By similarity). Interacts with CARD11 and MALT1; as CC part of a CBM (CARD11-BCL10-MALT1) complex involved in NF-kappa-B CC activation (By similarity). {ECO:0000250|UniProtKB:O95999, CC ECO:0000250|UniProtKB:Q9Z0H7}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O95999}. CC Membrane raft {ECO:0000250|UniProtKB:O95999}. Note=Colocalized with CC DPP4 in membrane rafts. {ECO:0000250|UniProtKB:O95999}. CC -!- PTM: Phosphorylated by IKBKB/IKKB. {ECO:0000250|UniProtKB:O95999}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB016069; BAA88822.1; -; mRNA. DR EMBL; BC061772; AAH61772.1; -; mRNA. DR RefSeq; NP_112618.1; NM_031328.1. DR BMRB; Q9QYN5; -. DR BioGRID; 249715; 2. DR STRING; 10116.ENSRNOP00000019911; -. DR iPTMnet; Q9QYN5; -. DR PhosphoSitePlus; Q9QYN5; -. DR PaxDb; Q9QYN5; -. DR PRIDE; Q9QYN5; -. DR Ensembl; ENSRNOT00000019911; ENSRNOP00000019911; ENSRNOG00000042389. DR GeneID; 83477; -. DR KEGG; rno:83477; -. DR CTD; 8915; -. DR RGD; 620544; Bcl10. DR eggNOG; ENOG502RXGH; Eukaryota. DR GeneTree; ENSGT00490000043442; -. DR HOGENOM; CLU_103803_0_0_1; -. DR InParanoid; Q9QYN5; -. DR KO; K07368; -. DR OMA; MRPYLCD; -. DR OrthoDB; 1472514at2759; -. DR PhylomeDB; Q9QYN5; -. DR Reactome; R-RNO-202424; Downstream TCR signaling. DR Reactome; R-RNO-2871837; FCERI mediated NF-kB activation. DR Reactome; R-RNO-5607764; CLEC7A (Dectin-1) signaling. DR Reactome; R-RNO-8866654; E3 ubiquitin ligases ubiquitinate target proteins. DR PRO; PR:Q9QYN5; -. DR Proteomes; UP000002494; Chromosome 2. DR Bgee; ENSRNOG00000042389; Expressed in jejunum and 21 other tissues. DR Genevisible; Q9QYN5; RN. DR GO; GO:0032449; C:CBM complex; ISS:UniProtKB. DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB. DR GO; GO:0005881; C:cytoplasmic microtubule; ISS:UniProtKB. DR GO; GO:0005829; C:cytosol; IDA:RGD. DR GO; GO:0001772; C:immunological synapse; ISO:RGD. DR GO; GO:0005764; C:lysosome; ISS:UniProtKB. DR GO; GO:0045121; C:membrane raft; ISO:RGD. DR GO; GO:0005634; C:nucleus; ISS:UniProtKB. DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB. DR GO; GO:0002096; C:polkadots; ISO:RGD. DR GO; GO:0032991; C:protein-containing complex; IDA:RGD. DR GO; GO:0050700; F:CARD domain binding; ISO:RGD. DR GO; GO:0019899; F:enzyme binding; ISO:RGD. DR GO; GO:0042802; F:identical protein binding; ISS:UniProtKB. DR GO; GO:0019209; F:kinase activator activity; IEA:Ensembl. DR GO; GO:0019900; F:kinase binding; ISS:UniProtKB. DR GO; GO:0051059; F:NF-kappaB binding; ISS:UniProtKB. DR GO; GO:0002020; F:protease binding; ISO:RGD. DR GO; GO:0008022; F:protein C-terminus binding; ISS:UniProtKB. DR GO; GO:0043422; F:protein kinase B binding; ISS:UniProtKB. DR GO; GO:0019901; F:protein kinase binding; ISS:UniProtKB. DR GO; GO:0043621; F:protein self-association; ISS:UniProtKB. DR GO; GO:0044877; F:protein-containing complex binding; IPI:RGD. DR GO; GO:0003713; F:transcription coactivator activity; ISS:UniProtKB. DR GO; GO:0008134; F:transcription factor binding; ISS:UniProtKB. DR GO; GO:0031625; F:ubiquitin protein ligase binding; ISS:UniProtKB. DR GO; GO:0002250; P:adaptive immune response; ISS:UniProtKB. DR GO; GO:0001783; P:B cell apoptotic process; ISO:RGD. DR GO; GO:0008219; P:cell death; ISS:UniProtKB. DR GO; GO:0006968; P:cellular defense response; ISO:RGD. DR GO; GO:0071222; P:cellular response to lipopolysaccharide; ISS:UniProtKB. DR GO; GO:0071260; P:cellular response to mechanical stimulus; ISO:RGD. DR GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; ISO:RGD. DR GO; GO:0016064; P:immunoglobulin mediated immune response; ISO:RGD. DR GO; GO:0045087; P:innate immune response; ISS:UniProtKB. DR GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; ISS:UniProtKB. DR GO; GO:0002906; P:negative regulation of mature B cell apoptotic process; ISS:UniProtKB. DR GO; GO:0001843; P:neural tube closure; ISS:UniProtKB. DR GO; GO:0043065; P:positive regulation of apoptotic process; IDA:RGD. DR GO; GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; ISO:RGD. DR GO; GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; ISS:UniProtKB. DR GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; ISS:UniProtKB. DR GO; GO:0032757; P:positive regulation of interleukin-8 production; ISS:UniProtKB. DR GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB. DR GO; GO:0042327; P:positive regulation of phosphorylation; ISS:UniProtKB. DR GO; GO:0031398; P:positive regulation of protein ubiquitination; ISS:UniProtKB. DR GO; GO:0050870; P:positive regulation of T cell activation; ISO:RGD. DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB. DR GO; GO:0050856; P:regulation of T cell receptor signaling pathway; ISO:RGD. DR GO; GO:0032094; P:response to food; ISS:UniProtKB. DR GO; GO:0009620; P:response to fungus; ISO:RGD. DR GO; GO:0070231; P:T cell apoptotic process; ISO:RGD. DR GO; GO:0050852; P:T cell receptor signaling pathway; ISS:UniProtKB. DR GO; GO:0002224; P:toll-like receptor signaling pathway; ISO:RGD. DR CDD; cd08810; CARD_BCL10; 1. DR InterPro; IPR033238; BCL10/E10. DR InterPro; IPR001315; CARD. DR InterPro; IPR042143; CARD_BCL10. DR InterPro; IPR011029; DEATH-like_dom_sf. DR PANTHER; PTHR34920; PTHR34920; 1. DR Pfam; PF00619; CARD; 1. DR SUPFAM; SSF47986; SSF47986; 1. DR PROSITE; PS50209; CARD; 1. PE 2: Evidence at transcript level; KW Acetylation; Apoptosis; Cytoplasm; Immunity; Membrane; Phosphoprotein; KW Reference proteome; Tumor suppressor. FT CHAIN 1..233 FT /note="B-cell lymphoma/leukemia 10" FT /id="PRO_0000144076" FT DOMAIN 13..101 FT /note="CARD" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00046" FT MOD_RES 1 FT /note="N-acetylmethionine" FT /evidence="ECO:0000250|UniProtKB:O95999" FT MOD_RES 138 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:O95999" SQ SEQUENCE 233 AA; 25999 MW; B43274B4B825FC7D CRC64; MEAPAPSLTE EDLTEVKKDA LENLRVYLCE KIIAERHFDH LRAKKILSRE DTEEISCRTS SRKRAGKLLD YLQENPKGLD TLVESIRREK TQNFLIQKIT DEVLKLRNIK LEHLKGLKCS SCEPFAAGAT NNLSRSNSDE SNFSEKQRPS TVIYHPEGES STAPFFSTES SLNLPVLEVG RLENSSFSSA SLPRPGDPGA PPLPPDLRLE EGGSCGNSSE MFLPLRSRAL SRQ //