ID BCL10_RAT Reviewed; 233 AA. AC Q9QYN5; DT 02-MAY-2002, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-2000, sequence version 1. DT 07-NOV-2018, entry version 124. DE RecName: Full=B-cell lymphoma/leukemia 10; DE AltName: Full=B-cell CLL/lymphoma 10; DE Short=Bcl-10; DE AltName: Full=R-RCD1; DE Short=RCD; GN Name=Bcl10; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Embryonic brain; RX PubMed=10753917; DOI=10.1074/jbc.275.15.11114; RA Yoneda T., Imaizumi K., Maeda M., Yui D., Manabe T., Katayama T., RA Sato N., Gomi F., Morihara T., Mori Y., Miyoshi K., Hitomi J., RA Ugawa S., Yamada S., Okabe M., Tohyama M.; RT "Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, RT a MALT lymphoma-associated protein."; RL J. Biol. Chem. 275:11114-11120(2000). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Prostate; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Involved in adaptive immune response. Promotes CC apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B CC via NIK and IKK. May be an adapter protein between upstream TNFR1- CC TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a CC substrate for MALT1. {ECO:0000250|UniProtKB:O95999}. CC -!- SUBUNIT: Found in a membrane raft complex, at least composed of CC BCL10, CARD11, DPP4 and IKBKB. Self-associates by CARD-CARD CC interaction and interacts with other CARD-proteins such as CARD9, CC CARD10, CARD11 and CARD14. Forms a complex with CARD14 and MALT1; CC resulting in the formation of a CBM (CARD14-BCL10-MALT1) complex. CC Binds caspase-9 with its C-terminal domain (By similarity). CC Interacts with TRAF2 and BIRC2/c-IAP2. Interacts with PELI2 and CC SOCS3; these interactions may be mutually exclusive (By CC similarity). Interacts with CARD11 and MALT1; as part of a CBM CC (CARD11-BCL10-MALT1) complex involved in NF-kappa-B activation (By CC similarity). {ECO:0000250|UniProtKB:O95999, CC ECO:0000250|UniProtKB:Q9Z0H7}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O95999}. CC Membrane raft {ECO:0000250|UniProtKB:O95999}. Note=Colocalized CC with DPP4 in membrane rafts. {ECO:0000250|UniProtKB:O95999}. CC -!- PTM: Phosphorylated by IKBKB/IKKB. {ECO:0000250|UniProtKB:O95999}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB016069; BAA88822.1; -; mRNA. DR EMBL; BC061772; AAH61772.1; -; mRNA. DR RefSeq; NP_112618.1; NM_031328.1. DR UniGene; Rn.13007; -. DR ProteinModelPortal; Q9QYN5; -. DR STRING; 10116.ENSRNOP00000019911; -. DR iPTMnet; Q9QYN5; -. DR PhosphoSitePlus; Q9QYN5; -. DR PaxDb; Q9QYN5; -. DR PRIDE; Q9QYN5; -. DR Ensembl; ENSRNOT00000019911; ENSRNOP00000019911; ENSRNOG00000042389. DR GeneID; 83477; -. DR KEGG; rno:83477; -. DR CTD; 8915; -. DR RGD; 620544; Bcl10. DR eggNOG; ENOG410IVMM; Eukaryota. DR eggNOG; ENOG4111JRA; LUCA. DR GeneTree; ENSGT00490000043442; -. DR HOGENOM; HOG000008671; -. DR HOVERGEN; HBG050680; -. DR InParanoid; Q9QYN5; -. DR KO; K07368; -. DR OMA; RHYLCDK; -. DR OrthoDB; EOG091G0UTQ; -. DR PhylomeDB; Q9QYN5; -. DR Reactome; R-RNO-202424; Downstream TCR signaling. DR Reactome; R-RNO-2871837; FCERI mediated NF-kB activation. DR Reactome; R-RNO-5607764; CLEC7A (Dectin-1) signaling. DR Reactome; R-RNO-8866654; E3 ubiquitin ligases ubiquitinate target proteins. DR PRO; PR:Q9QYN5; -. DR Proteomes; UP000002494; Chromosome 2. DR Bgee; ENSRNOG00000042389; Expressed in 10 organ(s), highest expression level in colon. DR Genevisible; Q9QYN5; RN. DR GO; GO:0032449; C:CBM complex; ISS:UniProtKB. DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB. DR GO; GO:0005881; C:cytoplasmic microtubule; ISS:UniProtKB. DR GO; GO:0005829; C:cytosol; IDA:RGD. DR GO; GO:0001772; C:immunological synapse; IEA:Ensembl. DR GO; GO:0005764; C:lysosome; ISS:UniProtKB. DR GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell. DR GO; GO:0005634; C:nucleus; ISS:UniProtKB. DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB. DR GO; GO:0032991; C:protein-containing complex; IDA:RGD. DR GO; GO:0050700; F:CARD domain binding; IEA:Ensembl. DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl. DR GO; GO:0019209; F:kinase activator activity; IEA:Ensembl. DR GO; GO:0019900; F:kinase binding; ISS:UniProtKB. DR GO; GO:0051059; F:NF-kappaB binding; ISS:UniProtKB. DR GO; GO:0002020; F:protease binding; IEA:Ensembl. DR GO; GO:0008022; F:protein C-terminus binding; ISS:UniProtKB. DR GO; GO:0043422; F:protein kinase B binding; ISS:UniProtKB. DR GO; GO:0019901; F:protein kinase binding; ISS:UniProtKB. DR GO; GO:0043621; F:protein self-association; ISS:UniProtKB. DR GO; GO:0003713; F:transcription coactivator activity; ISS:UniProtKB. DR GO; GO:0008134; F:transcription factor binding; ISS:UniProtKB. DR GO; GO:0031625; F:ubiquitin protein ligase binding; ISS:UniProtKB. DR GO; GO:0002250; P:adaptive immune response; ISS:UniProtKB. DR GO; GO:0001783; P:B cell apoptotic process; IEA:Ensembl. DR GO; GO:0008219; P:cell death; ISS:UniProtKB. DR GO; GO:0006968; P:cellular defense response; IEA:Ensembl. DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl. DR GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IBA:GO_Central. DR GO; GO:0016064; P:immunoglobulin mediated immune response; IEA:Ensembl. DR GO; GO:0045087; P:innate immune response; ISS:UniProtKB. DR GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; ISS:UniProtKB. DR GO; GO:0002906; P:negative regulation of mature B cell apoptotic process; ISS:UniProtKB. DR GO; GO:0001843; P:neural tube closure; ISS:UniProtKB. DR GO; GO:0043065; P:positive regulation of apoptotic process; IDA:RGD. DR GO; GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Ensembl. DR GO; GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; ISS:UniProtKB. DR GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; ISS:UniProtKB. DR GO; GO:0045416; P:positive regulation of interleukin-8 biosynthetic process; ISS:UniProtKB. DR GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB. DR GO; GO:0042327; P:positive regulation of phosphorylation; ISS:UniProtKB. DR GO; GO:0031398; P:positive regulation of protein ubiquitination; ISS:UniProtKB. DR GO; GO:0050870; P:positive regulation of T cell activation; IEA:Ensembl. DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB. DR GO; GO:0051259; P:protein complex oligomerization; ISS:UniProtKB. DR GO; GO:0051291; P:protein heterooligomerization; IPI:RGD. DR GO; GO:0051260; P:protein homooligomerization; ISS:UniProtKB. DR GO; GO:0050856; P:regulation of T cell receptor signaling pathway; IEA:Ensembl. DR GO; GO:0032094; P:response to food; ISS:UniProtKB. DR GO; GO:0009620; P:response to fungus; IEA:Ensembl. DR GO; GO:0002237; P:response to molecule of bacterial origin; ISS:UniProtKB. DR GO; GO:0070231; P:T cell apoptotic process; IEA:Ensembl. DR GO; GO:0050852; P:T cell receptor signaling pathway; ISS:UniProtKB. DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:Ensembl. DR InterPro; IPR033238; BCL10/E10. DR InterPro; IPR001315; CARD. DR InterPro; IPR011029; DEATH-like_dom_sf. DR PANTHER; PTHR34920; PTHR34920; 1. DR Pfam; PF00619; CARD; 1. DR SUPFAM; SSF47986; SSF47986; 1. DR PROSITE; PS50209; CARD; 1. PE 2: Evidence at transcript level; KW Acetylation; Apoptosis; Complete proteome; Cytoplasm; Immunity; KW Membrane; Phosphoprotein; Reference proteome; Tumor suppressor. FT CHAIN 1 233 B-cell lymphoma/leukemia 10. FT /FTId=PRO_0000144076. FT DOMAIN 13 101 CARD. {ECO:0000255|PROSITE- FT ProRule:PRU00046}. FT MOD_RES 1 1 N-acetylmethionine. FT {ECO:0000250|UniProtKB:O95999}. FT MOD_RES 138 138 Phosphoserine. FT {ECO:0000250|UniProtKB:O95999}. SQ SEQUENCE 233 AA; 25999 MW; B43274B4B825FC7D CRC64; MEAPAPSLTE EDLTEVKKDA LENLRVYLCE KIIAERHFDH LRAKKILSRE DTEEISCRTS SRKRAGKLLD YLQENPKGLD TLVESIRREK TQNFLIQKIT DEVLKLRNIK LEHLKGLKCS SCEPFAAGAT NNLSRSNSDE SNFSEKQRPS TVIYHPEGES STAPFFSTES SLNLPVLEVG RLENSSFSSA SLPRPGDPGA PPLPPDLRLE EGGSCGNSSE MFLPLRSRAL SRQ //