ID PKP3_MOUSE Reviewed; 797 AA. AC Q9QY23; A4QPD8; Q0VGP3; Q3KQL7; DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot. DT 12-JUN-2007, sequence version 2. DT 27-JUL-2011, entry version 75. DE RecName: Full=Plakophilin-3; GN Name=Pkp3; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RX MEDLINE=99310799; PubMed=10381383; RA Bonne S., van Hengel J., Nollet F., Kools P., van Roy F.; RT "Plakophilin-3, a novel armadillo-like protein present in nuclei and RT desmosomes of epithelial cells."; RL J. Cell Sci. 112:2265-2276(1999). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). RC STRAIN=C57BL/6, and FVB/N; TISSUE=Colon, and Eye; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [3] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-313, AND MASS RP SPECTROMETRY. RC TISSUE=Liver; RX PubMed=17242355; DOI=10.1073/pnas.0609836104; RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; RT "Large-scale phosphorylation analysis of mouse liver."; RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). RN [4] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-66, AND MASS RP SPECTROMETRY. RC TISSUE=Melanoma; RX PubMed=19367708; DOI=10.1021/pr800599n; RA Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., RA Faessler R., Mann M.; RT "Solid tumor proteome and phosphoproteome analysis by high resolution RT mass spectrometry."; RL J. Proteome Res. 7:5314-5326(2008). CC -!- FUNCTION: May play a role in junctional plaques. CC -!- SUBCELLULAR LOCATION: Nucleus. Cell junction, desmosome. CC Note=Nuclear and associated with desmosomes. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q9QY23-1; Sequence=Displayed; CC Name=2; CC IsoId=Q9QY23-2; Sequence=VSP_026139; CC Note=No experimental confirmation available; CC -!- SIMILARITY: Belongs to the beta-catenin family. CC -!- SIMILARITY: Contains 8 ARM repeats. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF136719; AAD55892.1; -; mRNA. DR EMBL; BC090668; AAH90668.1; -; mRNA. DR EMBL; BC106141; AAI06142.1; -; mRNA. DR EMBL; BC139775; AAI39776.1; -; mRNA. DR IPI; IPI00135464; -. DR IPI; IPI00850034; -. DR RefSeq; NP_001156396.1; NM_001162924.1. DR RefSeq; NP_062736.2; NM_019762.2. DR UniGene; Mm.350037; -. DR ProteinModelPortal; Q9QY23; -. DR SMR; Q9QY23; 319-784. DR STRING; Q9QY23; -. DR PhosphoSite; Q9QY23; -. DR PRIDE; Q9QY23; -. DR Ensembl; ENSMUST00000066873; ENSMUSP00000069961; ENSMUSG00000054065. DR Ensembl; ENSMUST00000106039; ENSMUSP00000101654; ENSMUSG00000054065. DR GeneID; 56460; -. DR KEGG; mmu:56460; -. DR NMPDR; fig|10090.3.peg.17916; -. DR UCSC; uc009kjh.2; mouse. DR UCSC; uc009kji.2; mouse. DR CTD; 11187; -. DR MGI; MGI:1891830; Pkp3. DR eggNOG; roNOG11208; -. DR GeneTree; ENSGT00550000074290; -. DR HOVERGEN; HBG106682; -. DR OMA; VSEQLEP; -. DR OrthoDB; EOG4C5CHV; -. DR PhylomeDB; Q9QY23; -. DR NextBio; 312706; -. DR ArrayExpress; Q9QY23; -. DR Bgee; Q9QY23; -. DR CleanEx; MM_PKP3; -. DR Genevestigator; Q9QY23; -. DR GermOnline; ENSMUSG00000054065; Mus musculus. DR GO; GO:0030057; C:desmosome; IDA:MGI. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0005488; F:binding; IEA:InterPro. DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW. DR InterPro; IPR011989; ARM-like. DR InterPro; IPR016024; ARM-type_fold. DR InterPro; IPR000225; Armadillo. DR Gene3D; G3DSA:1.25.10.10; ARM-like; 1. DR Pfam; PF00514; Arm; 1. DR SMART; SM00185; ARM; 3. DR SUPFAM; SSF48371; ARM-type_fold; 1. DR PROSITE; PS50176; ARM_REPEAT; 1. PE 1: Evidence at protein level; KW Alternative splicing; Cell adhesion; Cell junction; Complete proteome; KW Nucleus; Phosphoprotein; Repeat. FT CHAIN 1 797 Plakophilin-3. FT /FTId=PRO_0000064288. FT REPEAT 305 348 ARM 1. FT REPEAT 351 390 ARM 2. FT REPEAT 393 432 ARM 3. FT REPEAT 449 487 ARM 4. FT REPEAT 491 536 ARM 5. FT REPEAT 596 637 ARM 6. FT REPEAT 645 684 ARM 7. FT REPEAT 689 730 ARM 8. FT MOD_RES 66 66 Phosphoserine. FT MOD_RES 84 84 Phosphotyrosine (By similarity). FT MOD_RES 115 115 Phosphoserine (By similarity). FT MOD_RES 176 176 Phosphotyrosine (By similarity). FT MOD_RES 180 180 Phosphoserine (By similarity). FT MOD_RES 195 195 Phosphotyrosine (By similarity). FT MOD_RES 240 240 Phosphoserine (By similarity). FT MOD_RES 313 313 Phosphoserine. FT MOD_RES 314 314 Phosphoserine (By similarity). FT MOD_RES 390 390 Phosphotyrosine (By similarity). FT VAR_SEQ 1 12 MQEGNFLLSALQ -> MEPTAGSRTRMEPRRNCPTAGTSRM FT SQGASGGQTSGK (in isoform 2). FT /FTId=VSP_026139. FT CONFLICT 182 182 R -> P (in Ref. 1; AAD55892). FT CONFLICT 216 216 E -> K (in Ref. 1; AAD55892). FT CONFLICT 459 459 A -> P (in Ref. 1; AAD55892). SQ SEQUENCE 797 AA; 87333 MW; C2ECF73BDE7323B1 CRC64; MQEGNFLLSA LQPETGVCSL ALPSDLQLDR RGAEGPEADR LRAARVQEQV RARLLQLGQQ SRHNGSAELD GSAESARGMP RGQYHTMQTG FSSRSQGMSG DKTSTFRPIA KPAYSPASWS SRSAVDLTCS RRLSSAHNGG SAFGAVGYGG TQPTPPMPTR PVSFHERGGA ASRADYDTLS LRSLRLGPGG LDDRYSVVSE QLEPAAASTY RAYAYERQAS SGSSRAGGLD WPEATEGPPS RTIRAPAMRT LQRFQSSHRS RGGTGSVSGA GLEPVARAPS VRSLSLSLAD SGHLPDVRGL DSYTGHRTLQ RLSSGFDDID LPSAVKYLMA SDPNLQVLGA AYIQHRCYSD AAAKKQARSL QAVPRLVKLF NHANQEVQRH ATGAMRNLIY DNVDNKLALV EENGIFELLR TLREQDDELR KNVTGILWNL SSSDHLKDRL ARDTLEQLTD LVLSPLSGAG GPPLIQQNAS EAEIFYNATG FLRNLSSASQ ATRQKMRECH GLVDALVTYI NHALDVGKCE DKSVENAVCV LRNLSYRLYD EMPPSALQRL EGRGRRDMAG APPGEMVGCF TPQSRRLREL PLTADALTFA EVSKDPKGLE WLWSPQIVGL YNRLLQRCEL NRHTTEAAAG ALQNITAGDR RWAGVLSRLA LEQERILNPL LDRVRTADHN QLRSLTGLIR NLSRNARNKD EMSTKVVSHL IEKLPGSVGE KCPPAEVLVN IIAVLNNLVV ASPIAARDLL YFDGLRKLVF IKKKRDSPDS EKSSRAASSL LANLWQYSKL HRDFRAKGYR KEDFLGP //