ID PKP3_MOUSE Reviewed; 797 AA. AC Q9QY23; A4QPD8; Q0VGP3; Q3KQL7; DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot. DT 12-JUN-2007, sequence version 2. DT 15-MAR-2017, entry version 117. DE RecName: Full=Plakophilin-3; GN Name=Pkp3; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RX PubMed=10381383; RA Bonne S., van Hengel J., Nollet F., Kools P., van Roy F.; RT "Plakophilin-3, a novel armadillo-like protein present in nuclei and RT desmosomes of epithelial cells."; RL J. Cell Sci. 112:2265-2276(1999). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Colon, and Eye; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [3] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=17242355; DOI=10.1073/pnas.0609836104; RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; RT "Large-scale phosphorylation analysis of mouse liver."; RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). RN [4] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-123; SER-180 AND RP SER-331, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE RP ANALYSIS]. RC TISSUE=Brown adipose tissue, Kidney, Lung, and Pancreas; RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and RT expression."; RL Cell 143:1174-1189(2010). RN [5] RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-261, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Embryo; RX PubMed=24129315; DOI=10.1074/mcp.O113.027870; RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., RA Aguiar M., Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., RA Vemulapalli V., Bedford M.T., Comb M.J.; RT "Immunoaffinity enrichment and mass spectrometry analysis of protein RT methylation."; RL Mol. Cell. Proteomics 13:372-387(2014). CC -!- FUNCTION: May play a role in junctional plaques. CC -!- SUBCELLULAR LOCATION: Nucleus. Cell junction, desmosome. CC Note=Nuclear and associated with desmosomes. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q9QY23-1; Sequence=Displayed; CC Name=2; CC IsoId=Q9QY23-2; Sequence=VSP_026139; CC Note=No experimental confirmation available.; CC -!- SIMILARITY: Belongs to the beta-catenin family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF136719; AAD55892.1; -; mRNA. DR EMBL; BC090668; AAH90668.1; -; mRNA. DR EMBL; BC106141; AAI06142.1; -; mRNA. DR EMBL; BC139775; AAI39776.1; -; mRNA. DR CCDS; CCDS21999.1; -. [Q9QY23-1] DR CCDS; CCDS52437.1; -. [Q9QY23-2] DR RefSeq; NP_001156396.1; NM_001162924.1. [Q9QY23-2] DR RefSeq; NP_062736.2; NM_019762.2. [Q9QY23-1] DR UniGene; Mm.350037; -. DR ProteinModelPortal; Q9QY23; -. DR SMR; Q9QY23; -. DR STRING; 10090.ENSMUSP00000101654; -. DR iPTMnet; Q9QY23; -. DR PhosphoSitePlus; Q9QY23; -. DR PaxDb; Q9QY23; -. DR PeptideAtlas; Q9QY23; -. DR PRIDE; Q9QY23; -. DR Ensembl; ENSMUST00000066873; ENSMUSP00000069961; ENSMUSG00000054065. [Q9QY23-1] DR Ensembl; ENSMUST00000106039; ENSMUSP00000101654; ENSMUSG00000054065. [Q9QY23-2] DR GeneID; 56460; -. DR KEGG; mmu:56460; -. DR UCSC; uc009kjh.2; mouse. [Q9QY23-2] DR UCSC; uc009kji.2; mouse. [Q9QY23-1] DR CTD; 11187; -. DR MGI; MGI:1891830; Pkp3. DR eggNOG; KOG1048; Eukaryota. DR eggNOG; ENOG410Y21Q; LUCA. DR GeneTree; ENSGT00760000119167; -. DR HOGENOM; HOG000115567; -. DR HOVERGEN; HBG106682; -. DR InParanoid; Q9QY23; -. DR OMA; NARNKDE; -. DR OrthoDB; EOG091G01WL; -. DR PhylomeDB; Q9QY23; -. DR TreeFam; TF321877; -. DR Reactome; R-MMU-6805567; Keratinization. DR Reactome; R-MMU-6809371; Formation of the cornified envelope. DR ChiTaRS; Pkp3; mouse. DR PRO; PR:Q9QY23; -. DR Proteomes; UP000000589; Chromosome 7. DR Bgee; ENSMUSG00000054065; -. DR CleanEx; MM_PKP3; -. DR ExpressionAtlas; Q9QY23; baseline and differential. DR Genevisible; Q9QY23; MM. DR GO; GO:0030054; C:cell junction; ISO:MGI. DR GO; GO:0005913; C:cell-cell adherens junction; ISO:MGI. DR GO; GO:0030057; C:desmosome; IDA:MGI. DR GO; GO:0005654; C:nucleoplasm; ISO:MGI. DR GO; GO:0005634; C:nucleus; ISS:MGI. DR GO; GO:0005886; C:plasma membrane; ISO:MGI. DR GO; GO:0005914; C:spot adherens junction; ISS:MGI. DR GO; GO:0045294; F:alpha-catenin binding; ISO:MGI. DR GO; GO:0098641; F:cadherin binding involved in cell-cell adhesion; ISO:MGI. DR GO; GO:0050839; F:cell adhesion molecule binding; ISO:MGI. DR GO; GO:0002159; P:desmosome assembly; ISO:MGI. DR GO; GO:0090002; P:establishment of protein localization to plasma membrane; ISO:MGI. DR GO; GO:0016337; P:single organismal cell-cell adhesion; IEA:InterPro. DR Gene3D; 1.25.10.10; -; 2. DR InterPro; IPR011989; ARM-like. DR InterPro; IPR016024; ARM-type_fold. DR InterPro; IPR000225; Armadillo. DR InterPro; IPR028434; Plakophilin-3. DR InterPro; IPR028435; Plakophilin/d_Catenin. DR PANTHER; PTHR10372; PTHR10372; 1. DR PANTHER; PTHR10372:SF29; PTHR10372:SF29; 1. DR Pfam; PF00514; Arm; 1. DR SMART; SM00185; ARM; 4. DR SUPFAM; SSF48371; SSF48371; 1. DR PROSITE; PS50176; ARM_REPEAT; 1. PE 1: Evidence at protein level; KW Alternative splicing; Cell adhesion; Cell junction; Complete proteome; KW Methylation; Nucleus; Phosphoprotein; Reference proteome; Repeat. FT CHAIN 1 797 Plakophilin-3. FT /FTId=PRO_0000064288. FT REPEAT 305 348 ARM 1. FT REPEAT 351 390 ARM 2. FT REPEAT 393 432 ARM 3. FT REPEAT 449 487 ARM 4. FT REPEAT 491 536 ARM 5. FT REPEAT 596 637 ARM 6. FT REPEAT 645 684 ARM 7. FT REPEAT 689 730 ARM 8. FT MOD_RES 81 81 Omega-N-methylarginine. FT {ECO:0000250|UniProtKB:Q9Y446}. FT MOD_RES 123 123 Phosphoserine. FT {ECO:0000244|PubMed:21183079}. FT MOD_RES 180 180 Phosphoserine. FT {ECO:0000244|PubMed:21183079}. FT MOD_RES 183 183 Phosphoserine. FT {ECO:0000250|UniProtKB:Q9Y446}. FT MOD_RES 240 240 Phosphoserine. FT {ECO:0000250|UniProtKB:Q9Y446}. FT MOD_RES 250 250 Phosphothreonine. FT {ECO:0000250|UniProtKB:Q9Y446}. FT MOD_RES 261 261 Omega-N-methylarginine. FT {ECO:0000244|PubMed:24129315}. FT MOD_RES 313 313 Phosphoserine. FT {ECO:0000250|UniProtKB:Q9Y446}. FT MOD_RES 314 314 Phosphoserine. FT {ECO:0000250|UniProtKB:Q9Y446}. FT MOD_RES 331 331 Phosphoserine. FT {ECO:0000244|PubMed:21183079}. FT VAR_SEQ 1 12 MQEGNFLLSALQ -> MEPTAGSRTRMEPRRNCPTAGTSRM FT SQGASGGQTSGK (in isoform 2). FT {ECO:0000303|PubMed:15489334}. FT /FTId=VSP_026139. FT CONFLICT 182 182 R -> P (in Ref. 1; AAD55892). FT {ECO:0000305}. FT CONFLICT 216 216 E -> K (in Ref. 1; AAD55892). FT {ECO:0000305}. FT CONFLICT 459 459 A -> P (in Ref. 1; AAD55892). FT {ECO:0000305}. SQ SEQUENCE 797 AA; 87333 MW; C2ECF73BDE7323B1 CRC64; MQEGNFLLSA LQPETGVCSL ALPSDLQLDR RGAEGPEADR LRAARVQEQV RARLLQLGQQ SRHNGSAELD GSAESARGMP RGQYHTMQTG FSSRSQGMSG DKTSTFRPIA KPAYSPASWS SRSAVDLTCS RRLSSAHNGG SAFGAVGYGG TQPTPPMPTR PVSFHERGGA ASRADYDTLS LRSLRLGPGG LDDRYSVVSE QLEPAAASTY RAYAYERQAS SGSSRAGGLD WPEATEGPPS RTIRAPAMRT LQRFQSSHRS RGGTGSVSGA GLEPVARAPS VRSLSLSLAD SGHLPDVRGL DSYTGHRTLQ RLSSGFDDID LPSAVKYLMA SDPNLQVLGA AYIQHRCYSD AAAKKQARSL QAVPRLVKLF NHANQEVQRH ATGAMRNLIY DNVDNKLALV EENGIFELLR TLREQDDELR KNVTGILWNL SSSDHLKDRL ARDTLEQLTD LVLSPLSGAG GPPLIQQNAS EAEIFYNATG FLRNLSSASQ ATRQKMRECH GLVDALVTYI NHALDVGKCE DKSVENAVCV LRNLSYRLYD EMPPSALQRL EGRGRRDMAG APPGEMVGCF TPQSRRLREL PLTADALTFA EVSKDPKGLE WLWSPQIVGL YNRLLQRCEL NRHTTEAAAG ALQNITAGDR RWAGVLSRLA LEQERILNPL LDRVRTADHN QLRSLTGLIR NLSRNARNKD EMSTKVVSHL IEKLPGSVGE KCPPAEVLVN IIAVLNNLVV ASPIAARDLL YFDGLRKLVF IKKKRDSPDS EKSSRAASSL LANLWQYSKL HRDFRAKGYR KEDFLGP //