ID KCNH8_RAT Reviewed; 1102 AA. AC Q9QWS8; O88877; DT 28-NOV-2002, integrated into UniProtKB/Swiss-Prot. DT 28-NOV-2002, sequence version 2. DT 19-JAN-2010, entry version 78. DE RecName: Full=Potassium voltage-gated channel subfamily H member 8; DE AltName: Full=Voltage-gated potassium channel subunit Kv12.1; DE AltName: Full=Ether-a-go-go-like potassium channel 3; DE Short=ELK channel 3; GN Name=Kcnh8; Synonyms=Elk1, Elk3; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=98382545; PubMed=9714851; RX DOI=10.1111/j.1469-7793.1998.675bg.x; RA Shi W., Wang H.-S., Pan Z., Wymore R.S., Cohen I.S., McKinnon D., RA Dixon J.E.; RT "Cloning of a mammalian elk potassium channel gene and EAG mRNA RT distribution in rat sympathetic ganglia."; RL J. Physiol. (Lond.) 511:675-682(1998). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] OF 9-379. RC TISSUE=Brain cortex; RX MEDLINE=99043952; PubMed=9824707; RX DOI=10.1111/j.1469-7793.1998.647ba.x; RA Engeland B., Neu A., Ludwig J., Roeper J., Pongs O.; RT "Cloning and functional expression of rat ether-a-go-go-like K+ RT channel genes."; RL J. Physiol. (Lond.) 513:647-654(1998). RN [3] RP TISSUE SPECIFICITY. RX MEDLINE=20183472; PubMed=10718922; RX DOI=10.1046/j.1365-2826.2000.00447.x; RA Wulfsen I., Hauber H.-P., Schiemann D., Bauer C.K., Schwarz J.R.; RT "Expression of mRNA for voltage-dependent and inward-rectifying K RT channels in GH3/B6 cells and rat pituitary."; RL J. Neuroendocrinol. 12:263-272(2000). RN [4] RP TISSUE SPECIFICITY. RX MEDLINE=21319165; PubMed=11425889; RA Saganich M.J., Machado E., Rudy B.; RT "Differential expression of genes encoding subthreshold-operating RT voltage-gated K+ channels in brain."; RL J. Neurosci. 21:4609-4624(2001). CC -!- FUNCTION: Pore-forming (alpha) subunit of voltage-gated potassium CC channel. Elicits a slowly activating, outward rectifying current. CC Channel properties may be modulated by cAMP and subunit assembly. CC -!- SUBUNIT: The potassium channel is probably composed of a homo- or CC heterotetrameric complex of pore-forming alpha subunits that can CC associate with modulating beta subunits. CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Detected in superior cervical, mesenteric and CC coeliac ganglia. Expressed in brain (piriform cortex, olfactory CC tubercle, cerebral cortex, hippocampus pyramidial cells and CC dentate gyrus and basal ganglia of caudate/putamen and accumbens CC nucleus). Expressed in pituitary. CC -!- DOMAIN: The segment S4 is probably the voltage-sensor and is CC characterized by a series of positively charged amino acids at CC every third position. CC -!- SIMILARITY: Belongs to the potassium channel family. H (Eag) CC subfamily. CC -!- SIMILARITY: Contains 1 cyclic nucleotide-binding domain. CC -!- SIMILARITY: Contains 1 PAC (PAS-associated C-terminal) domain. CC -!- SIMILARITY: Contains 1 PAS (PER-ARNT-SIM) domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF061957; AAC61520.1; -; mRNA. DR EMBL; AJ007632; CAA07591.1; -; mRNA. DR IPI; IPI00212617; -. DR PIR; T17367; T17367. DR RefSeq; NP_659563.1; -. DR UniGene; Rn.30029; -. DR SMR; Q9QWS8; 27-135, 223-476, 481-664. DR Ensembl; ENSRNOT00000017246; ENSRNOP00000017246; ENSRNOG00000012711; Rattus norvegicus. DR GeneID; 246325; -. DR KEGG; rno:246325; -. DR UCSC; NM_145095; rat. DR CTD; 246325; -. DR RGD; 2549; Kcnh8. DR eggNOG; maNOG06555; -. DR HOVERGEN; Q9QWS8; -. DR InParanoid; Q9QWS8; -. DR NextBio; 623752; -. DR ArrayExpress; Q9QWS8; -. DR Genevestigator; Q9QWS8; -. DR GermOnline; ENSRNOG00000012711; Rattus norvegicus. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-SubCell. DR GO; GO:0030955; F:potassium ion binding; IEA:UniProtKB-KW. DR GO; GO:0003705; F:RNA polymerase II transcription factor acti...; IMP:RGD. DR GO; GO:0000155; F:two-component sensor activity; IEA:InterPro. DR GO; GO:0005249; F:voltage-gated potassium channel activity; IMP:RGD. DR GO; GO:0043066; P:negative regulation of apoptosis; IMP:RGD. DR GO; GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW. DR GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro. DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro. DR GO; GO:0000160; P:two-component signal transduction system (p...; IEA:InterPro. DR InterPro; IPR000595; cNMP_bd. DR InterPro; IPR018490; cNMP_bd-like. DR InterPro; IPR005821; Ion_trans. DR InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG. DR InterPro; IPR003950; K_chnl_volt-dep_ELK. DR InterPro; IPR001610; PAC. DR InterPro; IPR000014; PAS. DR InterPro; IPR000700; PAS-assoc_C. DR InterPro; IPR013656; PAS_4. DR InterPro; IPR014710; RmlC-like_jellyroll. DR Gene3D; G3DSA:2.60.120.10; RmlC-like_jellyroll; 1. DR Pfam; PF00027; cNMP_binding; 1. DR Pfam; PF00520; Ion_trans; 1. DR Pfam; PF08448; PAS_4; 1. DR PRINTS; PR01463; EAGCHANLFMLY. DR PRINTS; PR01465; ELKCHANNEL. DR SMART; SM00100; cNMP; 1. DR SMART; SM00086; PAC; 1. DR PROSITE; PS00888; CNMP_BINDING_1; FALSE_NEG. DR PROSITE; PS00889; CNMP_BINDING_2; FALSE_NEG. DR PROSITE; PS50042; CNMP_BINDING_3; 1. DR PROSITE; PS50113; PAC; 1. DR PROSITE; PS50112; PAS; FALSE_NEG. PE 2: Evidence at transcript level; KW Glycoprotein; Ion transport; Ionic channel; Membrane; Potassium; KW Potassium channel; Potassium transport; Transmembrane; Transport; KW Voltage-gated channel. FT CHAIN 1 1102 Potassium voltage-gated channel subfamily FT H member 8. FT /FTId=PRO_0000054020. FT TOPO_DOM 1 225 Cytoplasmic (Potential). FT TRANSMEM 226 246 Segment S1 (Potential). FT TRANSMEM 256 276 Segment S2 (Potential). FT TOPO_DOM 277 298 Cytoplasmic (Potential). FT TRANSMEM 299 319 Segment S3 (Potential). FT TRANSMEM 328 348 Segment S4 (Potential). FT TOPO_DOM 349 353 Cytoplasmic (Potential). FT TRANSMEM 354 374 Segment S5 (Potential). FT TRANSMEM 449 469 Segment S6 (Potential). FT TOPO_DOM 470 1102 Cytoplasmic (Potential). FT DOMAIN 18 90 PAS. FT DOMAIN 93 145 PAC. FT NP_BIND 551 668 cNMP. FT REGION 420 440 Segment H5 (pore-forming) (Potential). FT MOTIF 434 439 Selectivity filter (By similarity). FT COMPBIAS 711 722 Poly-Glu. FT CARBOHYD 320 320 N-linked (GlcNAc...) (Potential). FT CARBOHYD 409 409 N-linked (GlcNAc...) (Potential). FT CONFLICT 71 71 F -> L (in Ref. 2; CAA07591). FT CONFLICT 187 187 K -> N (in Ref. 2; CAA07591). FT CONFLICT 296 296 I -> T (in Ref. 2; CAA07591). FT CONFLICT 370 370 M -> I (in Ref. 2; CAA07591). SQ SEQUENCE 1102 AA; 123231 MW; A135CC36E2E7F1A3 CRC64; MPVMKGLLAP QNTFLDTIAT RFDGTHSNFI LANAQVAKGF PIVYCSDGFC ELAGFARTEV MQKSCSCKFL FGVETNEQLM LQIEKSLEEK VEFKGEIMFY KKNGAPFWCL LDIVPIKNEK GDVVLFLASF KDITDTKVKI TSEDKKEDRA KGRSRAGSHF DSARRRSRAV LYHISGHLQR REKNKLKINN NVFVDKPAFP EYKVSDAKKS KFILLHFSTF KAGWDWLILL ATFYVAVTVP YNVCFIGNED LSTTRSTTVS DIAVEILFII DIILNFRTTY VSKSGQVIFE ARSICIHYVT TWFIIDLIAA LPFDLLYAFN VTVVSLVHLL KTVRLLRLLR LLQKLDRYSQ HSTIVLTLLM SMFALLAHWM ACIWYVIGKM EREDNSLLKW EVGWLHELGK RLESPYYGNN TLGGPSIRSA YIAALYFTLS SLTSVGFGNV SANTDAEKIF SICTMLIGAL MHALVFGNVT AIIQRMYSRW SLYHTRTKDL KDFIRVHHLP QQLKQRMLEY FQTTWSVNNG IDSNELLKDF PDELRSDITM HLNKEILQLS LFECASRGCL RSLSLHIKTS FCAPGEYLLR QGDALQAIYF VCSGSMEVLK DSMVLAILGK GDLIGANLSI KDQVIKTNAD VKALTYCDLQ CIILKGLFEV LGLYPEYAHK FVEDIQHDLT YNLREGHESD VISRLSNKST VPQAEPKGNG SIKKRLPSIV EDEEEEEVEE EETTSLSPIY TRGSSVSHSK KTGSSKSYLG LSLKQLTSGT VPFHSPIRVS SANSPKTKQE ADPPNHGTRK EKNLKVQLCS LGTAGTPELS PRIVDGIEDG NSSEETQTFD FGSEQIRPEP RISPSLGESE IGAAFLFIKA EETKQQINKL NSEVTTLTQE VSQLGKDMRS IMQLLENILS PQQPSQFCSL HPTSICPSRE SFQTRVSWSA HQPCLHLQAN GAHLYHGNVT SDIWSVDPSL VGSNPQRTEA HEQSPVDSEL HHSPNLAYSP SHCQVIQEGH LQFLRCISPH SDTTLTPLQS ISATLSSSVC SSSETSLHLV LPSRSEEGSI THGPVSSFSL ENLPGSWDRE GMMSASTEPL ENFPVEVVTS TADVKDSKAI NV //