ID CD5L_MOUSE Reviewed; 352 AA. AC Q9QWK4; O35300; O35301; Q3TXN5; Q505P6; Q91W05; DT 16-APR-2002, integrated into UniProtKB/Swiss-Prot. DT 27-JUL-2011, sequence version 3. DT 11-JUL-2012, entry version 89. DE RecName: Full=CD5 antigen-like; DE AltName: Full=Apoptosis inhibitor expressed by macrophages; DE AltName: Full=Apoptosis inhibitory 6; DE AltName: Full=CT-2; DE AltName: Full=SP-alpha; DE Flags: Precursor; GN Name=Cd5l; Synonyms=Aim, Api6; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], VARIANTS MET-61; SER-197 AND ARG-205, RP TISSUE SPECIFICITY, AND GLYCOSYLATION. RC STRAIN=BALB/c; TISSUE=Thymus; RX MEDLINE=20118142; PubMed=10651944; RX DOI=10.1046/j.1365-2567.2000.00903.x; RA Gebe J.A., Llewellyn M.-B.C., Hoggatt H., Aruffo A.; RT "Molecular cloning, genomic organization and cell-binding RT characteristics of mouse Spalpha."; RL Immunology 99:78-86(2000). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION IN APOPTOSIS. RX MEDLINE=99110826; PubMed=9892623; DOI=10.1084/jem.189.2.413; RA Miyazaki T., Hirokami Y., Matsuhashi N., Takatsuka H., Naito M.; RT "Increased susceptibility of thymocytes to apoptosis in mice lacking RT AIM, a novel murine macrophage-derived soluble factor belonging to the RT scavenger receptor cysteine-rich domain superfamily."; RL J. Exp. Med. 189:413-422(1999). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6J; RX PubMed=16141072; DOI=10.1126/science.1112014; RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E., RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., RA Hayashizaki Y.; RT "The transcriptional landscape of the mammalian genome."; RL Science 309:1559-1563(2005). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT SER-197. RC STRAIN=FVB/N; TISSUE=Liver, and Mammary tumor; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: May play a role in the regulation of the immune system. CC Seems to play a role as an inhibitor of apoptosis. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Expressed in thymus, liver, spleen and lymph CC nodes. CC -!- PTM: Glycosylated. CC -!- SIMILARITY: Contains 3 SRCR domains. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF018268; AAB70571.1; -; mRNA. DR EMBL; AF018269; AAB70572.1; -; mRNA. DR EMBL; AF011428; AAD01445.1; -; mRNA. DR EMBL; AK159132; BAE34844.1; -; mRNA. DR EMBL; AK159181; BAE34880.1; -; mRNA. DR EMBL; AK159823; BAE35403.1; -; mRNA. DR EMBL; BC006799; AAH06799.1; -; mRNA. DR EMBL; BC094459; AAH94459.1; -; mRNA. DR IPI; IPI00316045; -. DR RefSeq; NP_033820.2; NM_009690.2. DR UniGene; Mm.6676; -. DR ProteinModelPortal; Q9QWK4; -. DR SMR; Q9QWK4; 24-131, 137-348. DR STRING; Q9QWK4; -. DR PRIDE; Q9QWK4; -. DR Ensembl; ENSMUST00000015998; ENSMUSP00000015998; ENSMUSG00000015854. DR GeneID; 11801; -. DR KEGG; mmu:11801; -. DR CTD; 922; -. DR MGI; MGI:1334419; Cd5l. DR eggNOG; NOG146070; -. DR GeneTree; ENSGT00650000093192; -. DR HOGENOM; HOG000290652; -. DR HOVERGEN; HBG031373; -. DR InParanoid; Q3TXN5; -. DR OMA; CSGEEQS; -. DR OrthoDB; EOG4868CM; -. DR NextBio; 279651; -. DR ArrayExpress; Q3TXN5; -. DR Bgee; Q3TXN5; -. DR CleanEx; MM_CD5L; -. DR Genevestigator; Q9QWK4; -. DR GermOnline; ENSMUSG00000015854; Mus musculus. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0016020; C:membrane; IEA:InterPro. DR GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro. DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. DR InterPro; IPR001190; Srcr_rcpt. DR InterPro; IPR017448; Srcr_rcpt-rel. DR Pfam; PF00530; SRCR; 3. DR PRINTS; PR00258; SPERACTRCPTR. DR SMART; SM00202; SR; 3. DR SUPFAM; SSF56487; Srcr_receptor; 3. DR PROSITE; PS00420; SRCR_1; 1. DR PROSITE; PS50287; SRCR_2; 3. PE 1: Evidence at protein level; KW Apoptosis; Complete proteome; Disulfide bond; Glycoprotein; KW Polymorphism; Reference proteome; Repeat; Secreted; Signal. FT SIGNAL 1 21 Potential. FT CHAIN 22 352 CD5 antigen-like. FT /FTId=PRO_0000033226. FT DOMAIN 27 128 SRCR 1. FT DOMAIN 141 241 SRCR 2. FT DOMAIN 246 348 SRCR 3. FT CARBOHYD 99 99 N-linked (GlcNAc...) (Potential). FT CARBOHYD 229 229 N-linked (GlcNAc...) (Potential). FT CARBOHYD 316 316 N-linked (GlcNAc...) (Potential). FT DISULFID 36 70 By similarity. FT DISULFID 52 117 By similarity. FT DISULFID 65 127 By similarity. FT DISULFID 98 108 By similarity. FT DISULFID 166 230 By similarity. FT DISULFID 179 240 By similarity. FT DISULFID 211 221 By similarity. FT DISULFID 255 289 By similarity. FT DISULFID 271 337 By similarity. FT DISULFID 284 347 By similarity. FT DISULFID 317 327 By similarity. FT VARIANT 61 61 V -> M. FT VARIANT 197 197 N -> S. FT VARIANT 205 205 W -> R. FT CONFLICT 13 13 S -> N (in Ref. 1; AAB70571). FT CONFLICT 113 113 D -> Y (in Ref. 2; AAD01445). SQ SEQUENCE 352 AA; 38863 MW; 41596AA8012E1AEE CRC64; MAPLFNLMLA ILSIFVGSCF SESPTKVQLV GGAHRCEGRV EVEHNGQWGT VCDDGWDRRD VAVVCRELNC GAVIQTPRGA SYQPPASEQR VLIQGVDCNG TEDTLAQCEL NYDVFDCSHE EDAGAQCENP DSDLLFIPED VRLVDGPGHC QGRVEVLHQS QWSTVCKAGW NLQVSKVVCR QLGCGRALLT YGSCNKNTQG KGPIWMGKMS CSGQEANLRS CLLSRLENNC THGEDTWMEC EDPFELKLVG GDTPCSGRLE VLHKGSWGSV CDDNWGEKED QVVCKQLGCG KSLHPSPKTR KIYGPGAGRI WLDDVNCSGK EQSLEFCRHR LWGYHDCTHK EDVEVICTDF DV //