ID CD5L_MOUSE STANDARD; PRT; 352 AA. AC Q9QWK4; O35300; O35301; Q91W05; DT 28-FEB-2003 (Rel. 41, Created) DT 28-FEB-2003 (Rel. 41, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE CD5 antigen-like precursor (SP-alpha) (CT-2) (Apoptosis inhibitory 6) DE (Apoptosis inhibitor expressed by macrophages). GN CD5L OR API6 OR AIM. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A., VARIANTS MET-61; ASN-197 AND ARG-205, TISSUE RP SPECIFICITY, AND GLYCOSYLATION. RC STRAIN=BALB/c; TISSUE=Thymus; RX MEDLINE=20118142; PubMed=10651944; RA Gebe J.A., Llewellyn M.-B.C., Hoggatt H., Aruffo A.; RT "Molecular cloning, genomic organization and cell-binding RT characteristics of mouse Spalpha."; RL Immunology 99:78-86(2000). RN [2] RP SEQUENCE FROM N.A., VARIANT ASN-197, AND FUNCTION IN APOPTOSIS. RX MEDLINE=99110826; PubMed=9892623; RA Miyazaki T., Hirokami Y., Matsuhashi N., Takatsuka H., Naito M.; RT "Increased susceptibility of thymocytes to apoptosis in mice lacking RT AIM, a novel murine macrophage-derived soluble factor belonging to RT the scavenger receptor cysteine-rich domain superfamily."; RL J. Exp. Med. 189:413-422(1999). RN [3] RP SEQUENCE FROM N.A. RC TISSUE=Breast tumor; RX MEDLINE=22388257; PubMed=12477932; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length RT human and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). CC -!- FUNCTION: May play a role in the regulation of the immune CC system. Seems to play a role as an inhibitor of apoptosis. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Expressed in thymus, liver, spleen and lymph CC nodes. CC -!- PTM: Glycosylated. CC -!- SIMILARITY: Contains 3 SRCR domains. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF018268; AAB70571.1; -. DR EMBL; AF018269; AAB70572.1; -. DR EMBL; AF011428; AAD01445.1; -. DR EMBL; BC006799; AAH06799.1; -. DR MGD; MGI:1334419; Cd5l. DR InterPro; IPR001190; Srcr_receptor. DR Pfam; PF00530; SRCR; 3. DR PRINTS; PR00258; SPERACTRCPTR. DR PROSITE; PS00420; SRCR_1; 1. DR PROSITE; PS50287; SRCR_2; 3. KW Signal; Repeat; Glycoprotein; Apoptosis; Polymorphism. FT SIGNAL 1 21 Potential. FT CHAIN 22 352 CD5 antigen-like. FT DOMAIN 27 128 SRCR 1. FT DOMAIN 141 241 SRCR 2. FT DOMAIN 246 348 SRCR 3. FT CARBOHYD 99 99 N-linked (GlcNAc...) (Potential). FT CARBOHYD 195 195 N-linked (GlcNAc...) (Potential). FT CARBOHYD 229 229 N-linked (GlcNAc...) (Potential). FT CARBOHYD 316 316 N-linked (GlcNAc...) (Potential). FT VARIANT 61 61 V -> M. FT VARIANT 197 197 S -> N. FT VARIANT 205 205 W -> R. FT CONFLICT 13 13 S -> N (in Ref. 1; AAB70571). FT CONFLICT 113 113 D -> Y (in Ref. 2). SQ SEQUENCE 352 AA; 38835 MW; 414984AACEF13B23 CRC64; MAPLFNLMLA ILSIFVGSCF SESPTKVQLV GGAHRCEGRV EVEHNGQWGT VCDDGWDRRD VAVVCRELNC GAVIQTPRGA SYQPPASEQR VLIQGVDCNG TEDTLAQCEL NYDVFDCSHE EDAGAQCENP DSDLLFIPED VRLVDGPGHC QGRVEVLHQS QWSTVCKAGW NLQVSKVVCR QLGCGRALLT YGSCNKSTQG KGPIWMGKMS CSGQEANLRS CLLSRLENNC THGEDTWMEC EDPFELKLVG GDTPCSGRLE VLHKGSWGSV CDDNWGEKED QVVCKQLGCG KSLHPSPKTR KIYGPGAGRI WLDDVNCSGK EQSLEFCRHR LWGYHDCTHK EDVEVICTDF DV //