ID Q9Q6V7 PRELIMINARY; PRT; 202 AA. AC Q9Q6V7; DT 01-MAY-2000 (TrEMBLrel. 13, Created) DT 01-MAY-2000 (TrEMBLrel. 13, Last sequence update) DT 01-MAR-2001 (TrEMBLrel. 16, Last annotation update) DE NEGATIVE FACTOR (F-PROTEIN) (27 KDA PROTEIN). GN NEF. OS Human immunodeficiency virus type 1. OC Viruses; Retroid viruses; Retroviridae; Lentivirus. OX NCBI_TaxID=11676; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=KAL153; RA Liitsola K., Holm K., Bobkov A., Pokrovski V., Smolskaja T., RA Leinikki P., Osmanov S., Salminen M.O.; RT "Recombinant and parental HIV-1 strains in Eastern Europe suggest low RT requirements for sequence identity in recombination."; RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: NEF HAS GTPASE, GTP-BINDING AND AUTOPHOSPHORYLATING CC ACTIVITIES, IT SEEMS TO DOWN REGULATE THE CD4(T4) ANTIGEN. NEF CC PROTEIN ACCELERATES VIRULENT PROGRESSION OF AIDS BY ITS CC INTERACTION WITH CELLULAR PROTEINS INVOLVED IN SIGNAL TRANSDUCTION CC AND HOST CELL ACTIVATION. NEF HAS BEEN SHOWN TO BIND SPECIFICALLY CC TO A SUBSET OF THE SRC KINASE FAMILY (BY SIMILARITY). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF193276; AAF22322.1; -. DR HSSP; Q70627; 2NEF. DR InterPro; IPR001558; -. DR Pfam; PF00469; F-protein; 1. KW AIDS; GTP-binding; Myristate. SQ SEQUENCE 202 AA; 23020 MW; 3B9EFBA099C97D93 CRC64; MGGKWSKSSI VGWPQVRERI RRAPAPAARG VGPVSQDLDK YGAVTSSNTA ANNADCAWLE AQEEEEVGFP VRPQVPLRPM TYKGAFDLSH FLKEKGGLDG LIYSKKRQEI LDLWVYHTQG YFPDWQPGIR FPLTFGWCYK LVPVDPAEVE EATEGENNSL LHPICQHGMD DEEKEVLMWK FDSRLALTHR ARELHPEFYK DC //