ID   Q9Q6V7      PRELIMINARY;      PRT;   202 AA.
AC   Q9Q6V7;
DT   01-MAY-2000 (TrEMBLrel. 13, Created)
DT   01-MAY-2000 (TrEMBLrel. 13, Last sequence update)
DT   01-MAR-2001 (TrEMBLrel. 16, Last annotation update)
DE   NEGATIVE FACTOR (F-PROTEIN) (27 KDA PROTEIN).
GN   NEF.
OS   Human immunodeficiency virus type 1.
OC   Viruses; Retroid viruses; Retroviridae; Lentivirus.
OX   NCBI_TaxID=11676;
RN   [1]
RP   SEQUENCE FROM N.A.
RC   STRAIN=KAL153;
RA   Liitsola K., Holm K., Bobkov A., Pokrovski V., Smolskaja T.,
RA   Leinikki P., Osmanov S., Salminen M.O.;
RT   "Recombinant and parental HIV-1 strains in Eastern Europe suggest low
RT   requirements for sequence identity in recombination.";
RL   Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: NEF HAS GTPASE, GTP-BINDING AND AUTOPHOSPHORYLATING
CC       ACTIVITIES, IT SEEMS TO DOWN REGULATE THE CD4(T4) ANTIGEN. NEF
CC       PROTEIN ACCELERATES VIRULENT PROGRESSION OF AIDS BY ITS
CC       INTERACTION WITH CELLULAR PROTEINS INVOLVED IN SIGNAL TRANSDUCTION
CC       AND HOST CELL ACTIVATION. NEF HAS BEEN SHOWN TO BIND SPECIFICALLY
CC       TO A SUBSET OF THE SRC KINASE FAMILY (BY SIMILARITY).
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DR   EMBL; AF193276; AAF22322.1; -.
DR   HSSP; Q70627; 2NEF.
DR   InterPro; IPR001558; -.
DR   Pfam; PF00469; F-protein; 1.
KW   AIDS; GTP-binding; Myristate.
SQ   SEQUENCE   202 AA;  23020 MW;  3B9EFBA099C97D93 CRC64;
     MGGKWSKSSI VGWPQVRERI RRAPAPAARG VGPVSQDLDK YGAVTSSNTA ANNADCAWLE
     AQEEEEVGFP VRPQVPLRPM TYKGAFDLSH FLKEKGGLDG LIYSKKRQEI LDLWVYHTQG
     YFPDWQPGIR FPLTFGWCYK LVPVDPAEVE EATEGENNSL LHPICQHGMD DEEKEVLMWK
     FDSRLALTHR ARELHPEFYK DC
//