ID Q9Q6V7 PRELIMINARY; PRT; 202 AA. AC Q9Q6V7; DT 01-MAY-2000 (TrEMBLrel. 13, Created) DT 01-MAY-2000 (TrEMBLrel. 13, Last sequence update) DT 01-OCT-2003 (TrEMBLrel. 25, Last annotation update) DE Nef protein (Negative factor) (27 kDa protein). GN NEF. OS Human immunodeficiency virus 1. OC Viruses; Retroid viruses; Retroviridae; Lentivirus. OX NCBI_TaxID=11676; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=KAL153; RX MEDLINE=20386750; PubMed=10933619; RA Liitsola K., Holm K., Bobkov A., Pokrovski V., Smolskaja T., RA Leinikki P., Osmanov S., Salminen M., UNAIDS Virus Isolation Network; RT "An AB recombinant and its parental HIV type 1 strains in the area of RT the former soviet union: low requirements for sequence identity in RT recombination."; RL AIDS Res. Hum. Retroviruses 16:1047-1053(2000). RN [2] RP SEQUENCE FROM N.A. RC STRAIN=KAL153; RA Liitsola K.; RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: NEF has GTPase, GTP-binding and autophosphorylating CC activities. It seems to down-regulate the CD4(T4) antigen (By CC similarity). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF193276; AAF22322.1; -. DR HSSP; P03406; 1EFN. DR GO; GO:0005525; F:GTP binding; IEA. DR InterPro; IPR001558; HIV_Nef. DR Pfam; PF00469; F-protein; 1. DR ProDom; PD000031; HIV_Nef; 1. KW AIDS; GTP-binding; Lipoprotein; Myristate. SQ SEQUENCE 202 AA; 23020 MW; 3B9EFBA099C97D93 CRC64; MGGKWSKSSI VGWPQVRERI RRAPAPAARG VGPVSQDLDK YGAVTSSNTA ANNADCAWLE AQEEEEVGFP VRPQVPLRPM TYKGAFDLSH FLKEKGGLDG LIYSKKRQEI LDLWVYHTQG YFPDWQPGIR FPLTFGWCYK LVPVDPAEVE EATEGENNSL LHPICQHGMD DEEKEVLMWK FDSRLALTHR ARELHPEFYK DC //