ID SYK_XYLFA Reviewed; 506 AA. AC Q9PEB6; DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2000, sequence version 1. DT 15-MAY-2007, entry version 47. DE Lysyl-tRNA synthetase (EC 6.1.1.6) (Lysine--tRNA ligase) (LysRS). GN Name=lysS; OrderedLocusNames=XF_1112; OS Xylella fastidiosa. OC Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales; OC Xanthomonadaceae; Xylella. OX NCBI_TaxID=2371; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=9a5c; RX MEDLINE=20365717; PubMed=10910347; DOI=10.1038/35018003; RA Simpson A.J.G., Reinach F.C., Arruda P., Abreu F.A., Acencio M., RA Alvarenga R., Alves L.M.C., Araya J.E., Baia G.S., Baptista C.S., RA Barros M.H., Bonaccorsi E.D., Bordin S., Bove J.M., Briones M.R.S., RA Bueno M.R.P., Camargo A.A., Camargo L.E.A., Carraro D.M., Carrer H., RA Colauto N.B., Colombo C., Costa F.F., Costa M.C.R., Costa-Neto C.M., RA Coutinho L.L., Cristofani M., Dias-Neto E., Docena C., El-Dorry H., RA Facincani A.P., Ferreira A.J.S., Ferreira V.C.A., Ferro J.A., RA Fraga J.S., Franca S.C., Franco M.C., Frohme M., Furlan L.R., RA Garnier M., Goldman G.H., Goldman M.H.S., Gomes S.L., Gruber A., RA Ho P.L., Hoheisel J.D., Junqueira M.L., Kemper E.L., Kitajima J.P., RA Krieger J.E., Kuramae E.E., Laigret F., Lambais M.R., Leite L.C.C., RA Lemos E.G.M., Lemos M.V.F., Lopes S.A., Lopes C.R., Machado J.A., RA Machado M.A., Madeira A.M.B.N., Madeira H.M.F., Marino C.L., RA Marques M.V., Martins E.A.L., Martins E.M.F., Matsukuma A.Y., RA Menck C.F.M., Miracca E.C., Miyaki C.Y., Monteiro-Vitorello C.B., RA Moon D.H., Nagai M.A., Nascimento A.L.T.O., Netto L.E.S., RA Nhani A. Jr., Nobrega F.G., Nunes L.R., Oliveira M.A., RA de Oliveira M.C., de Oliveira R.C., Palmieri D.A., Paris A., RA Peixoto B.R., Pereira G.A.G., Pereira H.A. Jr., Pesquero J.B., RA Quaggio R.B., Roberto P.G., Rodrigues V., de Rosa A.J.M., RA de Rosa V.E. Jr., de Sa R.G., Santelli R.V., Sawasaki H.E., RA da Silva A.C.R., da Silva A.M., da Silva F.R., Silva W.A. Jr., RA da Silveira J.F., Silvestri M.L.Z., Siqueira W.J., de Souza A.A., RA de Souza A.P., Terenzi M.F., Truffi D., Tsai S.M., Tsuhako M.H., RA Vallada H., Van Sluys M.A., Verjovski-Almeida S., Vettore A.L., RA Zago M.A., Zatz M., Meidanis J., Setubal J.C.; RT "The genome sequence of the plant pathogen Xylella fastidiosa."; RL Nature 406:151-159(2000). CC -!- CATALYTIC ACTIVITY: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate CC + L-lysyl-tRNA(Lys). CC -!- COFACTOR: Binds 3 magnesium ions per subunit (By similarity). CC -!- SUBUNIT: Homodimer (By similarity). CC -!- SUBCELLULAR LOCATION: Cytoplasm. CC -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase CC family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE003849; AAF83922.1; -; Genomic_DNA. DR PIR; E82721; E82721. DR HSSP; P13030; 1BBW. DR GenomeReviews; AE003849_GR; Xf1112. DR KEGG; xfa:XF1112; -. DR GO; GO:0005524; F:ATP binding; IEA:HAMAP. DR GO; GO:0004824; F:lysine-tRNA ligase activity; IEA:HAMAP. DR GO; GO:0000287; F:magnesium ion binding; IEA:HAMAP. DR GO; GO:0006430; P:lysyl-tRNA aminoacylation; IEA:HAMAP. DR HAMAP; MF_00252; -; 1. DR InterPro; IPR004365; NA_bd_OB_tRNA-helicase. DR InterPro; IPR004364; tRNA-synt_2. DR InterPro; IPR002313; tRNA-synt_lys_2. DR InterPro; IPR006195; tRNA_ligase_II. DR PANTHER; PTHR22594:SF4; tRNA-synt_lys_2; 1. DR Pfam; PF00152; tRNA-synt_2; 1. DR Pfam; PF01336; tRNA_anti; 1. DR PRINTS; PR00982; TRNASYNTHLYS. DR TIGRFAMs; TIGR00499; lysS_bact; 1. DR PROSITE; PS50862; AA_TRNA_LIGASE_II; 1. KW Aminoacyl-tRNA synthetase; ATP-binding; Complete proteome; Ligase; KW Magnesium; Metal-binding; Nucleotide-binding; Protein biosynthesis. FT CHAIN 1 506 Lysyl-tRNA synthetase. FT /FTId=PRO_0000152708. FT METAL 416 416 Magnesium 1 (By similarity). FT METAL 423 423 Magnesium 1 (By similarity). FT METAL 423 423 Magnesium 2 (By similarity). SQ SEQUENCE 506 AA; 57532 MW; B194E13ED1ECC6D0 CRC64; MTEHLPTSQV SFDENALIAE RRAKLLALRA QGVAYPNDVK REHYAADVQV AFANVETWTA EALEASGDRV RMAGRLMAKR LMGKASFAQI QDESGRIQLL IQSNVLGEDS YAAFKVLDVG DIIAVEGGLT RTRTGELSVK VNVLRLLTKA LRPLPDKWHG LTDVEQRYRQ RYVDLIVTPE SREIFIKRSK IIRALRTWLD ARLFLEVETP MMHYIPGGAA AKPFVTYHNA LDLELYLRVA PELYLKRLVV GGLERVYEIN RNFRNEGVST RHNPEFTMLE LYEAYSTYHE VMDLAETMIR DTAQSVLGTT QVIWDGAQID LGPIFRRWRM DEAVCHHNPE ISVAECTDRD ALLLHCERLK IKVKSSYGWG RLLLSIFEAT VEHTLIQPTF ITDHPVEISP LARESDIEPG YTDRFELFIN GKEIANGFSE LNDPEEQAMR FQKQVEAKEG GDDEAMYYDA DYIRALEYGM APTGGLGIGV DRLVMLLTGS TSIRDVLLFP YMRPER //