ID AKTR2_ALTAL Reviewed; 435 AA. AC Q9P4U8; DT 18-JUL-2018, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2000, sequence version 1. DT 18-SEP-2019, entry version 66. DE RecName: Full=Transcription activator AKTR-2 {ECO:0000303|PubMed:10975654}; DE AltName: Full=AK-toxin biosynthesis regulator 2 {ECO:0000303|PubMed:10975654}; GN Name=AKTR-2 {ECO:0000303|PubMed:10975654}; OS Alternaria alternata (Alternaria rot fungus) (Torula alternata). OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; OC Dothideomycetes; Pleosporomycetidae; Pleosporales; Pleosporineae; OC Pleosporaceae; Alternaria; Alternaria sect. Alternaria; OC Alternaria alternata complex. OX NCBI_TaxID=5599; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION. RC STRAIN=15A; RX PubMed=10975654; DOI=10.1094/mpmi.2000.13.9.975; RA Tanaka A., Tsuge T.; RT "Structural and functional complexity of the genomic region RT controlling AK-toxin biosynthesis and pathogenicity in the Japanese RT pear pathotype of Alternaria alternata."; RL Mol. Plant Microbe Interact. 13:975-986(2000). RN [2] RP REVIEW ON HOST-SELECTIVE TOXINS. RX PubMed=22846083; DOI=10.1111/j.1574-6976.2012.00350.x; RA Tsuge T., Harimoto Y., Akimitsu K., Ohtani K., Kodama M., Akagi Y., RA Egusa M., Yamamoto M., Otani H.; RT "Host-selective toxins produced by the plant pathogenic fungus RT Alternaria alternata."; RL FEMS Microbiol. Rev. 37:44-66(2013). CC -!- FUNCTION: Transcription factor that regulates the expression of CC the gene clusters that mediate the biosynthesis of the host- CC selective toxins (HSTs) AK-toxins responsible for Japanese pear CC black spot disease by the Japanese pear pathotype (Probable). AK- CC toxins are esters of 9,10-epoxy 8-hydroxy 9-methyldecatrienoic CC acid (EDA) (PubMed:22846083). On cellular level, AK-toxins affect CC plasma membrane of susceptible cells and cause a sudden increase CC in loss of K(+) after a few minutes of toxin treatment CC (PubMed:22846083). {ECO:0000303|PubMed:22846083, CC ECO:0000305|PubMed:10975654}. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE- CC ProRule:PRU00227}. CC -!- MISCELLANEOUS: Gene clusters encoding host-selective toxins (HSTs) CC are localized on conditionally dispensable chromosomes (CDCs), CC also called supernumerary chromosomes, where they are present in CC multiple copies (PubMed:10975654). The CDCs are not essential for CC saprophytic growth but controls host-selective pathogenicity CC (PubMed:10975654). {ECO:0000269|PubMed:10975654}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB035493; BAB07812.1; -; Genomic_DNA. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR CDD; cd00067; GAL4; 1. DR Gene3D; 4.10.240.10; -; 1. DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd. DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf. DR Pfam; PF00172; Zn_clus; 1. DR SMART; SM00066; GAL4; 1. DR SUPFAM; SSF57701; SSF57701; 1. DR PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1. DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1. PE 3: Inferred from homology; KW DNA-binding; Metal-binding; Nucleus; Transcription; KW Transcription regulation; Zinc. FT CHAIN 1 435 Transcription activator AKTR-2. FT /FTId=PRO_0000444842. FT DNA_BIND 16 43 Zn(2)-C6 fungal-type. FT {ECO:0000255|PROSITE-ProRule:PRU00227}. SQ SEQUENCE 435 AA; 48235 MW; AAD028C78F51A1C9 CRC64; MLQCAPKKNE RLRGSCDFCT QSKLRCNKNK PSCRRCTIQQ QVCVYSVARR TGRPPKHPRR ADDSQETSGQ HGHQDPMTSA PADSCEQQSS HLDLEGDDTD FTLVDGRTTA EGRATVAPPV LDNAFLMGET FEFNSLLDDP LVQSEDIFSF SPHIPRGEKG VHMASFHALN ESTSPCSPSA LLSIDVPQLP TNFRFLESFI GSELHGRNEP HPVEQPDEME KTYDKGSILL GLDSAINAIT NNGKDEPSIS GWTVARPHSK HLCFCSMSMS KLQVLVSHPA LCRQNSRTPF DMVLFLEEFV FGIHSDVLRC LICQSRSLHS LASLCICTDW VVEALVDVAQ DLSLGQDNLG GLRAEICPPK NGSSIYVGRL ILADQFRESC TRSLVKYRLR KLIPIMDTMI KLNYRGAGGA LSQAIRTMVE DVRHKIESAL GMMEL //