ID SIRB2_HUMAN STANDARD; PRT; 387 AA. AC Q9P1W8; Q8WWA5; Q9NQK8; DT 28-MAR-2003, integrated into UniProtKB/Swiss-Prot. DT 28-MAR-2003, sequence version 2. DT 04-APR-2006, entry version 41. DE Signal-regulatory protein beta-2 precursor (SIRP-beta-2) (SIRP-b2) DE (CD172g antigen). GN Name=SIRPB2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE (ISOFORM 2). RC TISSUE=Placenta; RX MEDLINE=21036165; PubMed=11185750; DOI=10.1007/s100380070013; RA Ichigotani Y., Matsuda S., Machida K., Oshima K., Iwamoto T., RA Yamaki K., Hayakawa T., Hamaguchi M.; RT "Molecular cloning of a novel human gene (SIRP-B2) which encodes a new RT member of the SIRP/SHPS-1 protein family."; RL J. Hum. Genet. 45:378-382(2000). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX MEDLINE=21638749; PubMed=11780052; DOI=10.1038/414865a; RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., RA Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., RA Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., RA Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., RA Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., RA Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., RA Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., RA Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., RA Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., RA Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., RA Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., RA Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., RA Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., RA Rogers J.; RT "The DNA sequence and comparative analysis of human chromosome 20."; RL Nature 414:865-871(2001). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). RC TISSUE=Lung; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). CC -!- FUNCTION: Probable immunoglobulin-like cell surface receptor. CC -!- SUBCELLULAR LOCATION: Membrane; single-pass type I membrane CC protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=Q9P1W8-1; Sequence=Displayed; CC Name=2; CC IsoId=Q9P1W8-2; Sequence=VSP_007027; CC Note=No experimental confirmation available; CC Name=3; CC IsoId=Q9P1W8-3; Sequence=VSP_007028; CC Note=No experimental confirmation available; CC -!- TISSUE SPECIFICITY: Detected in liver, and at very low levels in CC brain, heart, lung, pancreas, kidney, placenta and skeletal CC muscle. CC -!- SIMILARITY: Contains 2 Ig-like C1-type (immunoglobulin-like) CC domains. CC -!- SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) CC domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB042624; BAA95692.1; -; mRNA. DR EMBL; AL138804; CAC00474.1; -; Genomic_DNA. DR EMBL; BC020629; AAH20629.1; ALT_INIT; mRNA. DR UniGene; Hs.22974; -. DR Ensembl; ENSG00000089012; Homo sapiens. DR HGNC; HGNC:15757; SIRPB2. DR MIM; 605466; gene. DR LinkHub; Q9P1W8; -. DR GO; GO:0007267; P:cell-cell signaling; TAS. DR GO; GO:0007242; P:intracellular signaling cascade; TAS. DR GO; GO:0008285; P:negative regulation of cell proliferation; TAS. DR InterPro; IPR003599; Ig. DR InterPro; IPR007110; Ig-like. DR InterPro; IPR003597; Ig_c1. DR InterPro; IPR003006; Ig_MHC. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR013106; V-set. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF07686; V-set; 1. DR SMART; SM00409; IG; 1. DR SMART; SM00407; IGc1; 2. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS00290; IG_MHC; FALSE_NEG. KW Alternative splicing; Glycoprotein; Immunoglobulin domain; Membrane; KW Repeat; Signal; Transmembrane. FT SIGNAL 1 28 Potential. FT CHAIN 29 387 Signal-regulatory protein beta-2. FT /FTId=PRO_0000014957. FT TOPO_DOM 29 360 Extracellular (Potential). FT TRANSMEM 361 383 Potential. FT TOPO_DOM 384 387 Cytoplasmic (Potential). FT DOMAIN 29 137 Ig-like V-type. FT DOMAIN 146 245 Ig-like C1-type 1. FT DOMAIN 252 340 Ig-like C1-type 2. FT CARBOHYD 243 243 N-linked (GlcNAc...) (Potential). FT CARBOHYD 268 268 N-linked (GlcNAc...) (Potential). FT CARBOHYD 309 309 N-linked (GlcNAc...) (Potential). FT CARBOHYD 317 317 N-linked (GlcNAc...) (Potential). FT DISULFID 53 119 Potential. FT DISULFID 168 226 Potential. FT DISULFID 271 329 Potential. FT VARSPLIC 1 33 Missing (in isoform 2). FT /FTId=VSP_007027. FT VARSPLIC 144 360 Missing (in isoform 3). FT /FTId=VSP_007028. FT CONFLICT 263 263 A -> V (in Ref. 2). FT CONFLICT 286 286 L -> S (in Ref. 2). SQ SEQUENCE 387 AA; 42496 MW; F7F20C9F86E0E64B CRC64; MPVPASWPHP PGPFLLLTLL LGLTEVAGEE ELQMIQPEKL LLVTVGKTAT LHCTVTSLLP VGPVLWFRGV GPGRELIYNQ KEGHFPRVTT VSDLTKRNNM DFSIRISSIT PADVGTYYCV KFRKGSPENV EFKSGPGTEM ALGAKPSAPV VLGPAARTTP EHTVSFTCES HGFSPRDITL KWFKNGNELS DFQTNVDPTG QSVAYSIRST ARVVLDPWDV RSQVICEVAH VTLQGDPLRG TANLSEAIRV PPTLEVTQQP MRAGNQVNVT CQVRKFYPQS LQLTWLENGN VCQRETASTL TENKDGTYNW TSWFLVNISD QRDDVVLTCQ VKHDGQLAVS KRLALEVTVH QKDQSSDATP GPASSLTALL LIAVLLGPIY VPWKQKT //