ID   OR1A1_HUMAN             Reviewed;         309 AA.
AC   Q9P1Q5; A5D914; Q6IFM1; Q6NTA9; Q96R87;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   04-NOV-2008, sequence version 2.
DT   24-JUL-2024, entry version 170.
DE   RecName: Full=Olfactory receptor 1A1;
DE   AltName: Full=Olfactory receptor 17-7;
DE            Short=OR17-7;
DE   AltName: Full=Olfactory receptor OR17-11;
GN   Name=OR1A1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT HIS-128.
RX   PubMed=10673334; DOI=10.1006/geno.1999.6030;
RA   Glusman G., Sosinsky A., Ben-Asher E., Avidan N., Sonkin D., Bahar A.,
RA   Rosenthal A., Clifton S., Roe B., Ferraz C., Demaille J.G., Lancet D.;
RT   "Sequence, structure, and evolution of a complete human olfactory receptor
RT   gene cluster.";
RL   Genomics 63:227-245(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT SER-285.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-281, AND VARIANT HIS-128.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
RN   [5]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [6]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR1A1";
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF087918; AAF37311.1; -; Genomic_DNA.
DR   EMBL; CH471108; EAW90520.1; -; Genomic_DNA.
DR   EMBL; BC069169; AAH69169.1; -; mRNA.
DR   EMBL; BC128248; AAI28249.1; -; mRNA.
DR   EMBL; BC141934; AAI41935.1; -; mRNA.
DR   EMBL; BC141935; AAI41936.1; -; mRNA.
DR   EMBL; AF399555; AAK95040.1; -; Genomic_DNA.
DR   EMBL; BK004241; DAA04639.1; -; Genomic_DNA.
DR   CCDS; CCDS11022.1; -.
DR   RefSeq; NP_055380.2; NM_014565.2.
DR   AlphaFoldDB; Q9P1Q5; -.
DR   SMR; Q9P1Q5; -.
DR   BioGRID; 113973; 7.
DR   STRING; 9606.ENSP00000493179; -.
DR   GlyCosmos; Q9P1Q5; 2 sites, No reported glycans.
DR   GlyGen; Q9P1Q5; 2 sites.
DR   iPTMnet; Q9P1Q5; -.
DR   PhosphoSitePlus; Q9P1Q5; -.
DR   BioMuta; OR1A1; -.
DR   DMDM; 212276451; -.
DR   MassIVE; Q9P1Q5; -.
DR   PaxDb; 9606-ENSP00000305207; -.
DR   PeptideAtlas; Q9P1Q5; -.
DR   Antibodypedia; 52929; 59 antibodies from 16 providers.
DR   DNASU; 8383; -.
DR   Ensembl; ENST00000641322.1; ENSP00000492897.1; ENSG00000172146.4.
DR   Ensembl; ENST00000641732.2; ENSP00000493179.1; ENSG00000172146.4.
DR   GeneID; 8383; -.
DR   KEGG; hsa:8383; -.
DR   MANE-Select; ENST00000641732.2; ENSP00000493179.1; NM_014565.3; NP_055380.2.
DR   UCSC; uc010vrc.2; human.
DR   AGR; HGNC:8179; -.
DR   CTD; 8383; -.
DR   GeneCards; OR1A1; -.
DR   HGNC; HGNC:8179; OR1A1.
DR   HPA; ENSG00000172146; Tissue enhanced (retina).
DR   MIM; 618046; gene.
DR   neXtProt; NX_Q9P1Q5; -.
DR   PharmGKB; PA32051; -.
DR   VEuPathDB; HostDB:ENSG00000172146; -.
DR   eggNOG; ENOG502TF5D; Eukaryota.
DR   GeneTree; ENSGT00900000141057; -.
DR   HOGENOM; CLU_012526_5_5_1; -.
DR   InParanoid; Q9P1Q5; -.
DR   OMA; QEDFFFT; -.
DR   OrthoDB; 5401587at2759; -.
DR   PhylomeDB; Q9P1Q5; -.
DR   TreeFam; TF337210; -.
DR   PathwayCommons; Q9P1Q5; -.
DR   Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 8383; 6 hits in 746 CRISPR screens.
DR   GeneWiki; OR1A1; -.
DR   GenomeRNAi; 8383; -.
DR   Pharos; Q9P1Q5; Tdark.
DR   PRO; PR:Q9P1Q5; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; Q9P1Q5; Protein.
DR   Bgee; ENSG00000172146; Expressed in male germ line stem cell (sensu Vertebrata) in testis.
DR   ExpressionAtlas; Q9P1Q5; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   CDD; cd15235; 7tmA_OR1A-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR48001; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR48001:SF50; OLFACTORY RECEPTOR 1A1-RELATED; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..309
FT                   /note="Olfactory receptor 1A1"
FT                   /id="PRO_0000150412"
FT   TOPO_DOM        1..25
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..49
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        50..57
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..79
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        80..100
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..120
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..139
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..158
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        159..195
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..218
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        219..235
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        236..258
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        259..270
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        271..290
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        291..309
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        264
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        97..189
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         128
FT                   /note="R -> H (in dbSNP:rs4375699)"
FT                   /evidence="ECO:0000269|PubMed:10673334,
FT                   ECO:0000269|PubMed:12213199"
FT                   /id="VAR_047080"
FT   VARIANT         233
FT                   /note="V -> M (in dbSNP:rs17762735)"
FT                   /id="VAR_034161"
FT   VARIANT         285
FT                   /note="P -> S (in dbSNP:rs769427)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_020380"
SQ   SEQUENCE   309 AA;  34565 MW;  EE3D7E194C4CDD4D CRC64;
     MRENNQSSTL EFILLGVTGQ QEQEDFFYIL FLFIYPITLI GNLLIVLAIC SDVRLHNPMY
     FLLANLSLVD IFFSSVTIPK MLANHLLGSK SISFGGCLTQ MYFMIALGNT DSYILAAMAY
     DRAVAISRPL HYTTIMSPRS CIWLIAGSWV IGNANALPHT LLTASLSFCG NQEVANFYCD
     ITPLLKLSCS DIHFHVKMMY LGVGIFSVPL LCIIVSYIRV FSTVFQVPST KGVLKAFSTC
     GSHLTVVSLY YGTVMGTYFR PLTNYSLKDA VITVMYTAVT PMLNPFIYSL RNRDMKAALR
     KLFNKRISS
//