ID Q9P186_HUMAN Unreviewed; 560 AA. AC Q9P186; DT 01-OCT-2000, integrated into UniProtKB/TrEMBL. DT 01-OCT-2000, sequence version 1. DT 28-JUN-2023, entry version 102. DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552}; DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AAF69614.1}; RN [1] {ECO:0000313|EMBL:AAF69614.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Liver {ECO:0000313|EMBL:AAF69614.1}; RA Zhang C., Yu Y., Zhang S., Wei H., Zhang Y., Zhou G., Bi J., Liu M., He F.; RT "Functional prediction of the coding sequences of 79 new genes deduced by RT analysis of cDNA clones from human fetal liver."; RL Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; CC Evidence={ECO:0000256|ARBA:ARBA00001556}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF119860; AAF69614.1; -; mRNA. DR PIR; C56236; C56236. DR AlphaFoldDB; Q9P186; -. DR PeptideAtlas; Q9P186; -. DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW. DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC. DR CDD; cd18791; SF2_C_RHA; 1. DR Gene3D; 1.20.120.1080; -; 1. DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2. DR InterPro; IPR011709; DEAD-box_helicase_OB_fold. DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS. DR InterPro; IPR007502; Helicase-assoc_dom. DR InterPro; IPR001650; Helicase_C. DR InterPro; IPR027417; P-loop_NTPase. DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1. DR PANTHER; PTHR18934:SF83; PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16; 1. DR Pfam; PF04408; HA2; 1. DR Pfam; PF00271; Helicase_C; 1. DR Pfam; PF07717; OB_NTP_bind; 1. DR SMART; SM00847; HA2; 1. DR SMART; SM00490; HELICc; 1. DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1. DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1. DR PROSITE; PS51194; HELICASE_CTER; 1. PE 2: Evidence at transcript level; KW ATP-binding {ECO:0000256|ARBA:ARBA00022806}; KW Helicase {ECO:0000256|ARBA:ARBA00022806}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022806}. FT DOMAIN 117..290 FT /note="Helicase C-terminal" FT /evidence="ECO:0000259|PROSITE:PS51194" SQ SEQUENCE 560 AA; 63460 MW; 69321C1A832FBD7C CRC64; MESQPAQECL MQMFLPIEPA CFVEWLGTSP SQLGVVMVDE AHERTLHTDI LFGLIKDVAR FRPELKVLVA SATMDTARFS TFFDDAPVFR IPGRRFPVDI FYTKAPEADY LEACVVSVLQ IHVTQPPGDI LVFLTGQEEI EAACEMLQDR CCRLGSKIRE LLVLPIYANL PSDMQARIFQ PTPPGARKVV VATNIAETSL TIEGIIYVLD PGFCKQKSYN PRTGMESLTV TPCSKASANQ RAGRAGRVAA GKCFRLYTAW AYQHELEETT VPEIQRTSLG NVVLLLKSLG IHDLMHFDFL DPPPYETLLL ALEQLYALGA LNHLGELTTS GRKMAELPVD PMLSKMILAS EKYSCSEEIL TVAAMLSVNN SIFYRPKDKV VHADNARVNF FLPGGDHLVL LNVYTQWAES GYSSQWCYEN FVQFRSMRRA RDVREQLEGL LERVEVGLSS CQGDYIRVRK AITAGYFYHT ARLTRSGYRT VKQQQTVFIH PNSSLFEQQP RWLLYHELVL TTKEFMRQVL EIESSWLLEV APHYYKAKEL EDPHAKKMPK KIGKTREELG //