ID   IL20_HUMAN              Reviewed;         176 AA.
AC   Q9NYY1; Q17RB3; Q96QZ6;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2003, sequence version 2.
DT   05-OCT-2010, entry version 87.
DE   RecName: Full=Interleukin-20;
DE            Short=IL-20;
DE   AltName: Full=Cytokine Zcyto10;
DE   Flags: Precursor;
GN   Name=IL20; Synonyms=ZCYTO10; ORFNames=UNQ852/PRO1801;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=21097717; PubMed=11163236; DOI=10.1016/S0092-8674(01)00187-8;
RA   Blumberg H., Conklin D., Xu W.F., Grossmann A., Brender T.,
RA   Carollo S., Eagan M., Foster D., Haldeman B.A., Hammond A., Haugen H.,
RA   Jelinek L., Kelly J.D., Madden K., Maurer M.F., Parrish-Novak J.,
RA   Prunkard D., Sexson S., Sprecher C., Waggie K., West J.,
RA   Whitmore T.E., Yao L., Kuechle M.K., Dale B.A., Chandrasekher Y.A.;
RT   "Interleukin 20: discovery, receptor identification, and role in
RT   epidermal function.";
RL   Cell 104:9-19(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   MEDLINE=22887296; PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA   Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA   Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA   Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA   Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA   Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA   Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale
RT   effort to identify novel human secreted and transmembrane proteins: a
RT   bioinformatics assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RG   SeattleSNPs variation discovery resource;
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   PROTEIN SEQUENCE OF 25-39.
RX   PubMed=15340161; DOI=10.1110/ps.04682504;
RA   Zhang Z., Henzel W.J.;
RT   "Signal peptide prediction based on analysis of experimentally
RT   verified cleavage sites.";
RL   Protein Sci. 13:2819-2824(2004).
CC   -!- FUNCTION: Cytokine that may be involved in epidermal function and
CC       psoriasis. Acts through STAT3.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed at very low levels in skin, trachea,
CC       and other tissues.
CC   -!- SIMILARITY: Belongs to the IL-10 family.
CC   -!- WEB RESOURCE: Name=SeattleSNPs;
CC       URL="http://pga.gs.washington.edu/data/il20/";
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF224266; AAF36679.1; -; mRNA.
DR   EMBL; AY358320; AAQ88686.1; -; mRNA.
DR   EMBL; AF402002; AAK84423.1; -; Genomic_DNA.
DR   EMBL; BC069311; AAH69311.1; -; mRNA.
DR   EMBL; BC069364; AAH69364.1; -; mRNA.
DR   EMBL; BC069398; AAH69398.1; -; mRNA.
DR   EMBL; BC069425; AAH69425.1; -; mRNA.
DR   EMBL; BC069449; AAH69449.1; -; mRNA.
DR   EMBL; BC069487; AAH69487.1; -; mRNA.
DR   EMBL; BC069523; AAH69523.1; -; mRNA.
DR   EMBL; BC069559; AAH69559.1; -; mRNA.
DR   EMBL; BC074948; AAH74948.1; -; mRNA.
DR   EMBL; BC074949; AAH74949.1; -; mRNA.
DR   EMBL; BC117386; AAI17387.1; -; mRNA.
DR   EMBL; BC117390; AAI17391.1; -; mRNA.
DR   IPI; IPI00000048; -.
DR   RefSeq; NP_061194.2; -.
DR   UniGene; Hs.272373; -.
DR   ProteinModelPortal; Q9NYY1; -.
DR   SMR; Q9NYY1; 29-175.
DR   STRING; Q9NYY1; -.
DR   PRIDE; Q9NYY1; -.
DR   Ensembl; ENST00000367096; ENSP00000356063; ENSG00000162891.
DR   Ensembl; ENST00000367098; ENSP00000356065; ENSG00000162891.
DR   GeneID; 50604; -.
DR   KEGG; hsa:50604; -.
DR   UCSC; uc001her.1; human.
DR   CTD; 50604; -.
DR   GeneCards; GC01P207038; -.
DR   H-InvDB; HIX0028577; -.
DR   HGNC; HGNC:6002; IL20.
DR   HPA; CAB025802; -.
DR   MIM; 605619; gene.
DR   PharmGKB; PA29817; -.
DR   eggNOG; prNOG07517; -.
DR   HOGENOM; HBG279173; -.
DR   HOVERGEN; HBG108002; -.
DR   InParanoid; Q9NYY1; -.
DR   OMA; YQTPDHH; -.
DR   OrthoDB; EOG9RR92S; -.
DR   PhylomeDB; Q9NYY1; -.
DR   NextBio; 53100; -.
DR   ArrayExpress; Q9NYY1; -.
DR   Bgee; Q9NYY1; -.
DR   CleanEx; HS_IL20; -.
DR   Genevestigator; Q9NYY1; -.
DR   GermOnline; ENSG00000162891; Homo sapiens.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0045517; F:interleukin-20 receptor binding; TAS:UniProtKB.
DR   GO; GO:0045618; P:positive regulation of keratinocyte differe...; TAS:UniProtKB.
DR   GO; GO:0042517; P:positive regulation of tyrosine phosphoryla...; TAS:UniProtKB.
DR   GO; GO:0050727; P:regulation of inflammatory response; TAS:UniProtKB.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR020443; Interleukin-10/19/20/24.
DR   InterPro; IPR020423; Interleukin-10_CS.
DR   InterPro; IPR020442; Interleukin-20.
DR   PANTHER; PTHR11585; Interleukin_10; 1.
DR   Pfam; PF00726; IL10; 1.
DR   PRINTS; PR01935; INTRLEUKIN20.
DR   SMART; SM00188; IL10; 1.
DR   SUPFAM; SSF47266; 4_helix_cytokine; 1.
DR   PROSITE; PS00520; INTERLEUKIN_10; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Cytokine; Direct protein sequencing;
KW   Disulfide bond; Polymorphism; Secreted; Signal.
FT   SIGNAL        1     24
FT   CHAIN        25    176       Interleukin-20.
FT                                /FTId=PRO_0000015381.
FT   DISULFID     33    126       Potential.
FT   DISULFID     80    132       Potential.
FT   DISULFID     81    134       Potential.
FT   VARIANT     107    107       R -> Q (in dbSNP:rs35856950).
FT                                /FTId=VAR_049577.
FT   CONFLICT     48     48       E -> D (in Ref. 1; AAF36679).
FT   CONFLICT    126    126       C -> S (in Ref. 2; AAQ88686).
SQ   SEQUENCE   176 AA;  20072 MW;  8385992500B6C447 CRC64;
     MKASSLAFSL LSAAFYLLWT PSTGLKTLNL GSCVIATNLQ EIRNGFSEIR GSVQAKDGNI
     DIRILRRTES LQDTKPANRC CLLRHLLRLY LDRVFKNYQT PDHYTLRKIS SLANSFLTIK
     KDLRLCHAHM TCHCGEEAMK KYSQILSHFE KLEPQAAVVK ALGELDILLQ WMEETE
//