ID   RM39_HUMAN              Reviewed;         338 AA.
AC   Q9NYK5; Q5QTR3; Q96Q65; Q9BSQ7; Q9BZV6; Q9NX44;
DT   11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2005, sequence version 2.
DT   31-OCT-2006, entry version 53.
DE   Mitochondrial 39S ribosomal protein L39 (L39mt) (MRP-L39) (MRP-L5).
GN   Name=MRPL39; Synonyms=MRPL5; ORFNames=MSTP003, PRED22;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA   Choi D.K., Taylor T.D., Hattori M., Sakaki Y.;
RT   "Construction of a transcript map in the LL56-APP region of chromosome
RT   21q21.1-21.2.";
RL   Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 5-338 (ISOFORM 1).
RC   TISSUE=Heart;
RA   Hui R.T., Liu Y.Q., Liu B., Zhao B., Meng X.M., Sheng H., Xu Y.Y.,
RA   Wang X.Y., Ye J., Song L., Gao Y., Wei Y.J., Zhang C.L., Zhang J.,
RA   Chai M.Q., Chen J.Z., Sun Y.H., Zhou X.L., Jiang Y.X., Zhao X.W.,
RA   Liu S., Cao H.Q., Zhao Y., Liu D.Q., Ding J.F., Liu L.S., Gao R.L.,
RA   Wu Q.Y., Qiang B.Q., Yuan J.G., Liew C.C., Zhao M.S.;
RL   Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-338 (ISOFORM 1).
RC   TISSUE=Muscle;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 150-338 (ISOFORM 2).
RC   TISSUE=Heart;
RX   PubMed=11167009; DOI=10.1016/S0378-1119(00)00504-7;
RA   Spirina O., Bykhovskaya Y., Kajava A.V., O'Brien T.W., Nierlich D.P.,
RA   Mougey E.B., Sylvester J.E., Graack H.-R., Wittmann-Liebold B.,
RA   Fischel-Ghodsian N.;
RT   "Heart-specific splice-variant of a human mitochondrial ribosomal
RT   protein (mRNA processing; tissue specific splicing).";
RL   Gene 261:229-234(2000).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 175-183.
RX   MEDLINE=21429115; PubMed=11543634; DOI=10.1006/geno.2001.6622;
RA   Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S.,
RA   Watanabe K., Tanaka T.;
RT   "The human mitochondrial ribosomal protein genes: mapping of 54 genes
RT   to the chromosomes and implications for human disorders.";
RL   Genomics 77:65-70(2001).
RN   [7]
RP   IDENTIFICATION.
RX   PubMed=10593885; DOI=10.1074/jbc.274.51.36043;
RA   O'Brien T.W., Fiesler S.E., Denslow N.D., Thiede B.,
RA   Wittmann-Liebold B., Mougey E.B., Sylvester J.E., Graack H.R.;
RT   "Mammalian mitochondrial ribosomal proteins (2). Amino acid
RT   sequencing, characterization, and identification of corresponding gene
RT   sequences.";
RL   J. Biol. Chem. 274:36043-36051(1999).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9NYK5-1; Sequence=Displayed;
CC       Name=2; Synonyms=MRP-L5V1;
CC         IsoId=Q9NYK5-2; Sequence=VSP_005718;
CC   -!- TISSUE SPECIFICITY: Ubiquitous (isoform 1); heart-specific
CC       (isoform 2).
CC   -!- SIMILARITY: To the N-terminal of threonyl-tRNA synthetases.
CC   -!- CAUTION: Ref.2 sequence differs from that shown due to a
CC       frameshift in position 72.
CC   -!- CAUTION: Ref.1 indicates C21orf8 as a synonym for this orf, this
CC       is incorrect, C21orf8 is already assigned to another chromosome 21
CC       region.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-6 is the initiator.
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DR   EMBL; AF239727; AAF44696.1; ALT_INIT; mRNA.
DR   EMBL; AK000458; BAA91177.1; ALT_FRAME; mRNA.
DR   EMBL; AF109357; AAQ13505.1; ALT_INIT; mRNA.
DR   EMBL; BC004896; AAH04896.2; -; mRNA.
DR   EMBL; AF270511; AAK12856.1; -; mRNA.
DR   EMBL; AB051346; BAB54936.1; -; Genomic_DNA.
DR   UniGene; Hs.420696; -.
DR   Ensembl; ENSG00000154719; Homo sapiens.
DR   KEGG; hsa:54148; -.
DR   H-InvDB; HIX0016037; -.
DR   HGNC; HGNC:14027; MRPL39.
DR   ArrayExpress; Q9NYK5; -.
DR   RZPD-ProtExp; T1993; -.
DR   RZPD-ProtExp; V0696; -.
DR   RZPD-ProtExp; W0883; -.
DR   GO; GO:0005761; C:mitochondrial ribosome; NAS:UniProtKB.
DR   InterPro; IPR012675; Ferredoxin_fold.
DR   InterPro; IPR004095; TGS.
DR   InterPro; IPR012676; TGS-like.
DR   Pfam; PF02824; TGS; 1.
KW   Alternative splicing; Mitochondrion; Ribonucleoprotein;
KW   Ribosomal protein.
FT   CHAIN         1    338       Mitochondrial 39S ribosomal protein L39.
FT                                /FTId=PRO_0000087684.
FT   VAR_SEQ     324    338       VTEDQSKATEECTST -> TPFPILLLFTTQSFFTTSPESY
FT                                LLHGTVSE (in isoform 2).
FT                                /FTId=VSP_005718.
FT   CONFLICT    140    140       K -> E (in Ref. 2 and 4).
SQ   SEQUENCE   338 AA;  38722 MW;  75D138B6C6CF007E CRC64;
     MEALAMGSRA LRLWLVAPGG GIKWRFIATS PASQLSPTEL TEMRNDLFNK EKARQLSLTP
     RTEKIEVKHV GKTDPGTVFV MNKNISTPYS CAMHLSEWYC RKSILALVDG QPWDMYKPLT
     KSCEIKFLTF KDCDPGEVNK AYWRSCAMMM GCVIERAFKD EYMVNLVRAP EVPVISGAFC
     YDVVLDSKLD EWMPTKENLR SFTKDAHALI YKDLPFETLE VEAKVALEIF QHSKYKVDFI
     EEKASQNPER IVKLHRIGDF IDVSEGPLIP RTSICFQYEV SAVHNLQPTQ PSLIRRFQGV
     SLPVHLRAHF TIWDKLLERS RKMVTEDQSK ATEECTST
//