ID   CCD87_HUMAN             Reviewed;         849 AA.
AC   Q9NVE4; Q8NE76;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 2.
DT   22-APR-2020, entry version 111.
DE   RecName: Full=Coiled-coil domain-containing protein 87;
GN   Name=CCDC87;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LEU-217.
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Plays a role in spermatogenesis, where it is important for
CC       normal sperm head morphology. Also required for the acrosome reaction
CC       and thus normal male fertility. {ECO:0000250|UniProtKB:Q8CDL9}.
CC   -!- INTERACTION:
CC       Q9NVE4; Q01850: CDR2; NbExp=3; IntAct=EBI-749261, EBI-1181367;
CC       Q9NVE4; Q08379: GOLGA2; NbExp=6; IntAct=EBI-749261, EBI-618309;
CC       Q9NVE4; P19012: KRT15; NbExp=3; IntAct=EBI-749261, EBI-739566;
CC       Q9NVE4; P14373: TRIM27; NbExp=3; IntAct=EBI-749261, EBI-719493;
CC       Q9NVE4; Q9BYV2: TRIM54; NbExp=3; IntAct=EBI-749261, EBI-2130429;
CC       Q9NVE4; Q8N6Y0: USHBP1; NbExp=3; IntAct=EBI-749261, EBI-739895;
CC   -!- SIMILARITY: Belongs to the CCDC87 family. {ECO:0000305}.
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DR   EMBL; AK001648; BAA91808.1; -; mRNA.
DR   EMBL; AP001157; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC034469; AAH34469.1; -; mRNA.
DR   CCDS; CCDS8145.1; -.
DR   RefSeq; NP_060689.2; NM_018219.2.
DR   SMR; Q9NVE4; -.
DR   BioGrid; 120526; 16.
DR   IntAct; Q9NVE4; 11.
DR   STRING; 9606.ENSP00000328487; -.
DR   iPTMnet; Q9NVE4; -.
DR   PhosphoSitePlus; Q9NVE4; -.
DR   BioMuta; CCDC87; -.
DR   DMDM; 296434428; -.
DR   MassIVE; Q9NVE4; -.
DR   PaxDb; Q9NVE4; -.
DR   PeptideAtlas; Q9NVE4; -.
DR   PRIDE; Q9NVE4; -.
DR   ProteomicsDB; 82784; -.
DR   Antibodypedia; 44485; 94 antibodies.
DR   Ensembl; ENST00000333861; ENSP00000328487; ENSG00000182791.
DR   GeneID; 55231; -.
DR   KEGG; hsa:55231; -.
DR   UCSC; uc001oiq.5; human.
DR   CTD; 55231; -.
DR   GeneCards; CCDC87; -.
DR   HGNC; HGNC:25579; CCDC87.
DR   HPA; ENSG00000182791; Tissue enriched (testis).
DR   neXtProt; NX_Q9NVE4; -.
DR   OpenTargets; ENSG00000182791; -.
DR   PharmGKB; PA144596455; -.
DR   eggNOG; ENOG410IFC5; Eukaryota.
DR   eggNOG; ENOG410XQT4; LUCA.
DR   GeneTree; ENSGT00390000018647; -.
DR   HOGENOM; CLU_016540_0_0_1; -.
DR   InParanoid; Q9NVE4; -.
DR   OMA; FVPGEWD; -.
DR   OrthoDB; 365617at2759; -.
DR   PhylomeDB; Q9NVE4; -.
DR   TreeFam; TF353429; -.
DR   GenomeRNAi; 55231; -.
DR   Pharos; Q9NVE4; Tdark.
DR   PRO; PR:Q9NVE4; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q9NVE4; protein.
DR   Bgee; ENSG00000182791; Expressed in left testis and 49 other tissues.
DR   Genevisible; Q9NVE4; HS.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:2000344; P:positive regulation of acrosome reaction; ISS:UniProtKB.
DR   GO; GO:1905516; P:positive regulation of fertilization; ISS:UniProtKB.
DR   GO; GO:0007338; P:single fertilization; IEA:UniProtKB-KW.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR037383; CCDC87.
DR   PANTHER; PTHR16078; PTHR16078; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Differentiation; Fertilization; Polymorphism;
KW   Reference proteome; Spermatogenesis.
FT   CHAIN           1..849
FT                   /note="Coiled-coil domain-containing protein 87"
FT                   /id="PRO_0000295145"
FT   COILED          387..415
FT                   /evidence="ECO:0000255"
FT   VARIANT         156
FT                   /note="A -> T (in dbSNP:rs1110707)"
FT                   /id="VAR_056782"
FT   VARIANT         217
FT                   /note="F -> L (in dbSNP:rs17853294)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_033224"
FT   CONFLICT        738
FT                   /note="L -> R (in Ref. 1; BAA91808)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        834
FT                   /note="K -> R (in Ref. 1; BAA91808)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   849 AA;  96402 MW;  6FFEAD6E56B6BCD8 CRC64;
     MMEPPKPEPE LQRFYHRLLR PLSLFPTRTT SPEPQKRPPQ EGRILQSFPL AKLTVASLCS
     QVAKLLAGSG IAAGVPPEAR LRLIKVILDE LKCSWREPPA ELSLSHKNNQ KLRKRLEAYV
     LLSSEQLFLR YLHLLVTMST PRGVFTESAT LTRLAASLAR DCTLFLTSPN VYRGLLADFQ
     ALLRAEQASG DVDKLHPVCP AGTFKLCPIP WPHSTGFAQV QCSNLNLNYL IQLSRPPEFL
     NEPGRMDPVK ELKSIPRLKR KKPFHWLPSI GKKREIDISS SQMVSLPSYP VAPTSRASPS
     PFCPELRRGQ SMPSLREGWR LADELGLPPL PSRPLTPLVL ATESKPELTG LIVAEDLKQL
     IKKMKLEGTR YPPLDSGLPP LLGVVTRHPA AGHRLEELEK MLRNLQEEEA SGQWDPQPPK
     SFPLHPQPVT ITLKLRNEVV VQAAAVRVSD RNFLDSFHIE GAGALYNHLA GELDPKAIEK
     MDIDNFVGST TREVYKELMS HVSSDHLHFD QGPLVEPAAD KDWSTFLSSA FLRQEKQPQI
     INPELVGLYS QRANTLQSNT KKMPSLPSLQ ATKSWEKWSN KASLMNSWKT TLSVDDYFKY
     LTNHETDFLH VIFQMHEEEV PVEIVAPARE SLEIQHPPPL LEDEEPDFVP GEWDWNTVLE
     HRLGAGKTPH LGEPHKILSL QKHLEQLWSV LEVPDKDQVD MTIKYSSKAR LRQLPSLVNA
     WERALKPIQL REALLARLEW FEGQASNPNR FFKKTNLSSS HFLEENQVRS HLHRKLNLME
     SSLVSLLEEI ELIFGEPVIF KGRPYLDKMK SDKVEMLYWL QQQRRVRHLV SALKDPHQST
     LFRSSAASL
//