ID SRTD4_HUMAN Reviewed; 356 AA. AC Q9NUC0; B2RD32; DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2000, sequence version 1. DT 02-OCT-2024, entry version 138. DE RecName: Full=SERTA domain-containing protein 4; GN Name=SERTAD4; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Corpus callosum; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16710414; DOI=10.1038/nature04727; RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.; RT "The DNA sequence and biological annotation of human chromosome 1."; RL Nature 441:315-321(2006). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Kidney; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- INTERACTION: CC Q9NUC0; Q0VDC6: FKBP1A; NbExp=3; IntAct=EBI-1773811, EBI-10226858; CC Q9NUC0; P54652: HSPA2; NbExp=3; IntAct=EBI-1773811, EBI-356991; CC Q9NUC0; P49591: SARS1; NbExp=3; IntAct=EBI-1773811, EBI-1053431; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK315386; BAG37779.1; -; mRNA. DR EMBL; AL035414; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471100; EAW93433.1; -; Genomic_DNA. DR EMBL; BC012083; AAH12083.1; -; mRNA. DR CCDS; CCDS1494.1; -. DR RefSeq; NP_062551.1; NM_019605.3. DR AlphaFoldDB; Q9NUC0; -. DR BioGRID; 121121; 19. DR IntAct; Q9NUC0; 19. DR STRING; 9606.ENSP00000355979; -. DR iPTMnet; Q9NUC0; -. DR PhosphoSitePlus; Q9NUC0; -. DR BioMuta; SERTAD4; -. DR DMDM; 74752974; -. DR jPOST; Q9NUC0; -. DR MassIVE; Q9NUC0; -. DR PaxDb; 9606-ENSP00000355979; -. DR PeptideAtlas; Q9NUC0; -. DR Pumba; Q9NUC0; -. DR Antibodypedia; 34600; 97 antibodies from 19 providers. DR DNASU; 56256; -. DR Ensembl; ENST00000367012.4; ENSP00000355979.3; ENSG00000082497.12. DR Ensembl; ENST00000630425.2; ENSP00000486369.1; ENSG00000281230.3. DR GeneID; 56256; -. DR KEGG; hsa:56256; -. DR MANE-Select; ENST00000367012.4; ENSP00000355979.3; NM_019605.5; NP_062551.1. DR UCSC; uc001hhy.4; human. DR AGR; HGNC:25236; -. DR CTD; 56256; -. DR DisGeNET; 56256; -. DR GeneCards; SERTAD4; -. DR HGNC; HGNC:25236; SERTAD4. DR HPA; ENSG00000082497; Low tissue specificity. DR neXtProt; NX_Q9NUC0; -. DR OpenTargets; ENSG00000082497; -. DR PharmGKB; PA134897438; -. DR VEuPathDB; HostDB:ENSG00000082497; -. DR eggNOG; ENOG502S9V2; Eukaryota. DR GeneTree; ENSGT00530000063876; -. DR HOGENOM; CLU_069835_0_0_1; -. DR InParanoid; Q9NUC0; -. DR OMA; CSHQVDY; -. DR OrthoDB; 5402426at2759; -. DR PhylomeDB; Q9NUC0; -. DR TreeFam; TF336235; -. DR PathwayCommons; Q9NUC0; -. DR SignaLink; Q9NUC0; -. DR BioGRID-ORCS; 56256; 11 hits in 1146 CRISPR screens. DR ChiTaRS; SERTAD4; human. DR GenomeRNAi; 56256; -. DR Pharos; Q9NUC0; Tdark. DR PRO; PR:Q9NUC0; -. DR Proteomes; UP000005640; Chromosome 1. DR RNAct; Q9NUC0; protein. DR Bgee; ENSG00000082497; Expressed in calcaneal tendon and 108 other cell types or tissues. DR GO; GO:0005634; C:nucleus; IEA:InterPro. DR InterPro; IPR009263; SERTA_dom. DR InterPro; IPR029708; SERTAD4. DR PANTHER; PTHR14272; SERTA DOMAIN-CONTAINING PROTEIN 4; 1. DR PANTHER; PTHR14272:SF4; SERTA DOMAIN-CONTAINING PROTEIN 4; 1. DR Pfam; PF06031; SERTA; 1. DR PROSITE; PS51053; SERTA; 1. PE 1: Evidence at protein level; KW Proteomics identification; Reference proteome. FT CHAIN 1..356 FT /note="SERTA domain-containing protein 4" FT /id="PRO_0000314139" FT DOMAIN 101..147 FT /note="SERTA" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00396" FT REGION 33..53 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 215..238 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 280..302 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 332..356 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 280..295 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 356 AA; 39348 MW; AC08F5241EFECE74 CRC64; MTLVLSMNRF CEPIVSEGAA EIAGYQTLWE ADSYGGPSPP GPAQAPLQGD RGAGPPLAGS HYRGISNPIT TSKITYFKRK YVEEEDFHPP LSSCSHKTIS IFEERAHILY MSLEKLKFID DPEVYLRRSV LINNLMKRIH GEIIMQNNWC FPACSFNGTS AQEWFMAQDC PYRKRPRMAK EECEKFHACC FYQECGGHYL NLPLSVNANV GSASTAASSP SASSSSSSSS SSPPLPLPSC SRQVDFDVGS ASIYKSDGQI PANEIFVTNV RSLGVQEKAK LNDEKANDDT NRDGGPLSHE PVGNDLAFEC KGQFYDYFET GYNERNNVNE SWKKSLRKKE ASPPSNKLCC SKGSKI //