ID SRTD4_HUMAN Reviewed; 356 AA. AC Q9NUC0; B2RD32; DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2000, sequence version 1. DT 07-APR-2021, entry version 124. DE RecName: Full=SERTA domain-containing protein 4; GN Name=SERTAD4; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Corpus callosum; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16710414; DOI=10.1038/nature04727; RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.; RT "The DNA sequence and biological annotation of human chromosome 1."; RL Nature 441:315-321(2006). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Kidney; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- INTERACTION: CC Q9NUC0; Q0VDC6: FKBP1A; NbExp=3; IntAct=EBI-1773811, EBI-10226858; CC Q9NUC0; P54652: HSPA2; NbExp=3; IntAct=EBI-1773811, EBI-356991; CC Q9NUC0; P49591: SARS1; NbExp=3; IntAct=EBI-1773811, EBI-1053431; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK315386; BAG37779.1; -; mRNA. DR EMBL; AL035414; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471100; EAW93433.1; -; Genomic_DNA. DR EMBL; BC012083; AAH12083.1; -; mRNA. DR CCDS; CCDS1494.1; -. DR RefSeq; NP_062551.1; NM_019605.3. DR BioGRID; 121121; 17. DR IntAct; Q9NUC0; 15. DR STRING; 9606.ENSP00000355979; -. DR iPTMnet; Q9NUC0; -. DR PhosphoSitePlus; Q9NUC0; -. DR BioMuta; SERTAD4; -. DR DMDM; 74752974; -. DR jPOST; Q9NUC0; -. DR MassIVE; Q9NUC0; -. DR PaxDb; Q9NUC0; -. DR PeptideAtlas; Q9NUC0; -. DR PRIDE; Q9NUC0; -. DR ProteomicsDB; 82663; -. DR Antibodypedia; 34600; 95 antibodies. DR DNASU; 56256; -. DR Ensembl; ENST00000367012; ENSP00000355979; ENSG00000082497. DR Ensembl; ENST00000630425; ENSP00000486369; ENSG00000281230. DR GeneID; 56256; -. DR KEGG; hsa:56256; -. DR UCSC; uc001hhy.4; human. DR CTD; 56256; -. DR GeneCards; SERTAD4; -. DR HGNC; HGNC:25236; SERTAD4. DR HPA; ENSG00000082497; Tissue enhanced (salivary). DR neXtProt; NX_Q9NUC0; -. DR OpenTargets; ENSG00000082497; -. DR PharmGKB; PA134897438; -. DR VEuPathDB; HostDB:ENSG00000082497.11; -. DR eggNOG; ENOG502S9V2; Eukaryota. DR GeneTree; ENSGT00530000063876; -. DR HOGENOM; CLU_069835_0_0_1; -. DR InParanoid; Q9NUC0; -. DR OMA; CSHQVDY; -. DR OrthoDB; 1034563at2759; -. DR PhylomeDB; Q9NUC0; -. DR TreeFam; TF336235; -. DR PathwayCommons; Q9NUC0; -. DR BioGRID-ORCS; 56256; 3 hits in 978 CRISPR screens. DR ChiTaRS; SERTAD4; human. DR GenomeRNAi; 56256; -. DR Pharos; Q9NUC0; Tdark. DR PRO; PR:Q9NUC0; -. DR Proteomes; UP000005640; Chromosome 1. DR RNAct; Q9NUC0; protein. DR Bgee; ENSG00000082497; Expressed in forebrain and 208 other tissues. DR Genevisible; Q9NUC0; HS. DR GO; GO:0005634; C:nucleus; IEA:InterPro. DR InterPro; IPR009263; SERTA_dom. DR InterPro; IPR029708; SERTAD4. DR PANTHER; PTHR14272; PTHR14272; 1. DR Pfam; PF06031; SERTA; 1. DR PROSITE; PS51053; SERTA; 1. PE 1: Evidence at protein level; KW Reference proteome. FT CHAIN 1..356 FT /note="SERTA domain-containing protein 4" FT /id="PRO_0000314139" FT DOMAIN 101..147 FT /note="SERTA" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00396" FT COMPBIAS 212..241 FT /note="Ser-rich" SQ SEQUENCE 356 AA; 39348 MW; AC08F5241EFECE74 CRC64; MTLVLSMNRF CEPIVSEGAA EIAGYQTLWE ADSYGGPSPP GPAQAPLQGD RGAGPPLAGS HYRGISNPIT TSKITYFKRK YVEEEDFHPP LSSCSHKTIS IFEERAHILY MSLEKLKFID DPEVYLRRSV LINNLMKRIH GEIIMQNNWC FPACSFNGTS AQEWFMAQDC PYRKRPRMAK EECEKFHACC FYQECGGHYL NLPLSVNANV GSASTAASSP SASSSSSSSS SSPPLPLPSC SRQVDFDVGS ASIYKSDGQI PANEIFVTNV RSLGVQEKAK LNDEKANDDT NRDGGPLSHE PVGNDLAFEC KGQFYDYFET GYNERNNVNE SWKKSLRKKE ASPPSNKLCC SKGSKI //