ID   RHG8_HUMAN     STANDARD;      PRT;   718 AA.
AC   Q9NSG0; O75983; O95695; Q96RW1; Q96RW2; Q9HA49; Q9HC46; Q9NVX8;
AC   Q9NXL1; Q9UH20;
DT   28-FEB-2003 (Rel. 41, Created)
DT   28-FEB-2003 (Rel. 41, Last sequence update)
DT   15-MAR-2004 (Rel. 43, Last annotation update)
DE   Rho-GTPase-activating protein 8 (PP610).
GN   ARHGAP8.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A. (ISOFORM 4).
RA   Gu J.R., Wan D.F., Zhao X.T., Zhou X.M., Jiang H.Q., Zhang P.P.,
RA   Qin W.X., Huang Y., Qiu X.K., Qian L.F., He L.P., Li H.N., Yu Y.,
RA   Yu J., Han L.H.;
RT   "Novel human cDNA clones with function of inhibiting cancer cell
RT   growth.";
RL   Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   SEQUENCE FROM N.A. (ISOFORMS 1 AND 2).
RA   McDermid H.E., Hu S., Grundy P., Trichet V.;
RT   "ARHGAP8: a putative tumor-suppressor gene on chromosome 22q13.3.";
RL   Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   SEQUENCE FROM N.A. (ISOFORMS 5; 6 AND 7).
RC   TISSUE=Colon mucosa, and Mammary gland;
RX   PubMed=14702039;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J.-I., Saito K., Kawai Y., Isono Y., Nakamura Y.,
RA   Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M.,
RA   Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H.,
RA   Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E.,
RA   Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M.,
RA   Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K.,
RA   Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y.,
RA   Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T.,
RA   Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O.,
RA   Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M.,
RA   Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   SEQUENCE FROM N.A. (ISOFORM 3).
RA   Goward M.E., Huckle E.J.;
RL   Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=20057165; PubMed=10591208;
RA   Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M.,
RA   Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K.,
RA   Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P.,
RA   Bird C.P., Blakey S.E., Bridgeman A.M., Buck D., Burgess J.,
RA   Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G.,
RA   Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R.,
RA   Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E.,
RA   Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G.,
RA   Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA   Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA   Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S.,
RA   Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A.,
RA   Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M.,
RA   Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T.,
RA   Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J.,
RA   Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T.,
RA   Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T.,
RA   Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L.,
RA   Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M.,
RA   Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA   Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA   Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA   Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J.,
RA   Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S.,
RA   Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T.,
RA   Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I.,
RA   Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H.,
RA   Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L.,
RA   Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z.,
RA   Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P.,
RA   Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S.,
RA   Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J.,
RA   Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T.,
RA   Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J.,
RA   Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA   Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S.,
RA   Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E.,
RA   Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P.,
RA   Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E.,
RA   O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X.,
RA   Khan A.S., Lane L., Tilahun Y., Wright H.;
RT   "The DNA sequence of human chromosome 22.";
RL   Nature 402:489-495(1999).
CC   -!- FUNCTION: GTPase activator for the Rho-type GTPases by converting
CC       them to an inactive GDP-bound state (By similarity).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=8;
CC         Comment=Additional isoforms seem to exist. Full isoforms so far
CC         detected are isoforms 1 to 7. Experimental confirmation may be
CC         lacking for some isoforms;
CC       Name=8;
CC         IsoId=Q9NSG0-1; Sequence=Displayed;
CC       Name=1;
CC         IsoId=Q9NSG0-2; Sequence=VSP_001645, VSP_001649, VSP_001652;
CC       Name=2;
CC         IsoId=Q9NSG0-3; Sequence=VSP_001645, VSP_001649, VSP_001653,
CC                                  VSP_001655;
CC       Name=3;
CC         IsoId=Q9NSG0-4; Sequence=VSP_001651;
CC       Name=4;
CC         IsoId=Q9NSG0-5; Sequence=VSP_001650, VSP_001654;
CC       Name=5;
CC         IsoId=Q9NSG0-6; Sequence=VSP_001647;
CC       Name=6;
CC         IsoId=Q9NSG0-7; Sequence=VSP_001647, VSP_001652, VSP_001656,
CC                                  VSP_001657;
CC       Name=7;
CC         IsoId=Q9NSG0-8; Sequence=VSP_001646, VSP_001648, VSP_001650,
CC                                  VSP_001654;
CC   -!- SIMILARITY: Contains 1 CRAL-TRIO domain.
CC   -!- SIMILARITY: Contains 1 Rho-GAP domain.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF177331; AAG17975.1; -.
DR   EMBL; AF195968; AAK58136.1; -.
DR   EMBL; AF195969; AAK58137.1; -.
DR   EMBL; AK000192; BAA90999.1; -.
DR   EMBL; AK001306; BAA91614.1; -.
DR   EMBL; AK022305; BAB14008.1; -.
DR   EMBL; AL355192; CAB90248.1; -.
DR   EMBL; Z98743; CAB11416.1; ALT_INIT.
DR   EMBL; Z93244; CAB07531.1; ALT_SEQ.
DR   EMBL; Z83838; CAB62993.1; ALT_INIT.
DR   PIR; B59436; B59436.
DR   HSSP; Q07960; 1RGP.
DR   Genew; HGNC:677; ARHGAP8.
DR   InterPro; IPR001251; CRAL_TRIO_C.
DR   InterPro; IPR008936; Rho_GAP.
DR   InterPro; IPR000198; RhoGAP.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   PROSITE; PS50191; CRAL_TRIO; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
KW   GTPase activation; Alternative splicing.
FT   DOMAIN      267    453       CRAL-TRIO.
FT   DOMAIN      480    666       Rho-GAP.
FT   VARSPLIC      1     95       Missing (in isoform 1 and isoform 2).
FT                                /FTId=VSP_001645.
FT   VARSPLIC      1    101       Missing (in isoform 7).
FT                                /FTId=VSP_001646.
FT   VARSPLIC      1    254       Missing (in isoform 5 and isoform 6).
FT                                /FTId=VSP_001647.
FT   VARSPLIC    102    107       KIRFYE -> MAPMPT (in isoform 7).
FT                                /FTId=VSP_001648.
FT   VARSPLIC    108    230       Missing (in isoform 1 and isoform 2).
FT                                /FTId=VSP_001649.
FT   VARSPLIC    232    388       LQRDKAAAAAVLGAVRKRPSVVPMAGQDPALSTSHPFYDVA
FT                                RHGILQVAGDDRFGRRVVTFSCCRMPPSHELDHQRLLEYLK
FT                                YTLDQYVENDYTIVYFHYGLNSRNKPSLGWLQSAYKEFDRK
FT                                DGDLTMWPRLVSNSKLKRSSHLSLPKYWDYRYKK -> KRL
FT                                LRRSRSGDVLAKNPVVRSKSYNTPLLNPVQEHEAEGAAAGG
FT                                TSIRRHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSG
FT                                PCPSRLYPTTQPPEQGLDPTRSSLPRSSPENLVDQILESVD
FT                                SDSEGIFIDFGRGRGSGMSDLEGSGGRQSVV (in
FT                                isoform 4 and isoform 7).
FT                                /FTId=VSP_001650.
FT   VARSPLIC    311    385       Missing (in isoform 3).
FT                                /FTId=VSP_001651.
FT   VARSPLIC    355    385       Missing (in isoform 1 and isoform 6).
FT                                /FTId=VSP_001652.
FT   VARSPLIC    386    451       YKKNLKALYVVHPTSFIKVLWNILKPLISHKFGKKVIYFNY
FT                                LSELHEHLKYDQLVIPPEVLRYDEK -> QEPPCQANTLVL
FT                                KGPDSQHFSFAGLLLYCNNSAGLCSSKTLWTLKCEFHVIFT
FT                                CHEIFFCFFFSTT (in isoform 2).
FT                                /FTId=VSP_001653.
FT   VARSPLIC    389    718       Missing (in isoform 4 and isoform 7).
FT                                /FTId=VSP_001654.
FT   VARSPLIC    452    718       Missing (in isoform 2).
FT                                /FTId=VSP_001655.
FT   VARSPLIC    579    579       V -> A (in isoform 6).
FT                                /FTId=VSP_001656.
FT   VARSPLIC    580    718       Missing (in isoform 6).
FT                                /FTId=VSP_001657.
SQ   SEQUENCE   718 AA;  81953 MW;  7181835625487465 CRC64;
     MRTLRRLKFM SSPSLSDLGK REPAAAADER GTQQRRACAN ATWNSIHNGV IAVFQRKGLP
     DQELFSLNEG VRQLLKTELG SFFTEYLQNQ LLTKGMVILR DKIRFYEGQK LLDSLAETWD
     FFFSDVLPML QAIFYPVQGK EPSVRQLALL HFRNAITLSV KLEDALARAH ARVPPAIVQM
     LLVLQGVHES RGVTEDYLRL ETLVQKVVSP YLGTYGLHSS EGPFTHSCIL ELQRDKAAAA
     AVLGAVRKRP SVVPMAGQDP ALSTSHPFYD VARHGILQVA GDDRFGRRVV TFSCCRMPPS
     HELDHQRLLE YLKYTLDQYV ENDYTIVYFH YGLNSRNKPS LGWLQSAYKE FDRKDGDLTM
     WPRLVSNSKL KRSSHLSLPK YWDYRYKKNL KALYVVHPTS FIKVLWNILK PLISHKFGKK
     VIYFNYLSEL HEHLKYDQLV IPPEVLRYDE KLQSLHEGRT PPPTKTPPPR PPLPTQQFGV
     SLQYLKDKNQ GELIPPVLRF TVTYLREKGL RTEGLFRRSA SVQTVREIQR LYNQGKPVNF
     DDYGDIHIPA VILKTFLREL PQPLLTFQAY EQILGITCVE SSLRVTGCRQ ILRSLPEHNY
     VVLRYLMGFL HAVSRESIFN KMNSSNLACV FGLNLIWPSQ GVSSLSALVP LNMFTELLIE
     YYEKIFSTPE APGEHGLAPW EQGSRAAPLQ EAVPRTQATG LTKPTLPPSP LMAARRRL
//