ID ZHANG_HUMAN Reviewed; 354 AA. AC Q9NS37; B2R8Q9; Q0P5U9; Q52LT3; DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot. DT 07-JUL-2009, sequence version 2. DT 05-FEB-2025, entry version 178. DE RecName: Full=CREB/ATF bZIP transcription factor; DE AltName: Full=Host cell factor-binding transcription factor Zhangfei; DE Short=HCF-binding transcription factor Zhangfei; GN Name=CREBZF; Synonyms=ZF; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] {ECO:0000305, ECO:0000312|EMBL:AAD28325.1} RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH HCFC1, TISSUE RP SPECIFICITY, MOTIF, AND MUTAGENESIS OF ASP-303; HIS-304 AND TYR-306. RC TISSUE=Cervix carcinoma; RX PubMed=10871379; DOI=10.1093/nar/28.12.2446; RA Lu R., Misra V.; RT "Zhangfei: a second cellular protein interacts with herpes simplex virus RT accessory factor HCF in a manner similar to Luman and VP16."; RL Nucleic Acids Res. 28:2446-2454(2000). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16554811; DOI=10.1038/nature04632; RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G., RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., RA Hattori M., Rogers J., Lander E.S., Sakaki Y.; RT "Human chromosome 11 DNA sequence and analysis including novel gene RT identification."; RL Nature 440:497-500(2006). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain, and Placenta; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 18-354. RC TISSUE=Hippocampus; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [5] RP NUCLEOTIDE SEQUENCE [MRNA] OF 74-354. RC TISSUE=Bone marrow; RA Zhang J.W., Zhang X., Ma Y.N.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000305} RP FUNCTION AS A SUPPRESSOR OF CREB3 TRANSCRIPTIONAL ACTIVITY, INTERACTION RP WITH CREB3 AND HCFC1, SUBCELLULAR LOCATION, AND MUTAGENESIS OF TYR-306. RX PubMed=15705566; DOI=10.1074/jbc.m500728200; RA Misra V., Rapin N., Akhova O., Bainbridge M., Korchinski P.; RT "Zhangfei is a potent and specific inhibitor of the host cell factor- RT binding transcription factor Luman."; RL J. Biol. Chem. 280:15257-15266(2005). RN [7] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., RA Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver RT phosphoproteome."; RL J. Proteomics 96:253-262(2014). CC -!- FUNCTION: Strongly activates transcription when bound to HCFC1. CC Suppresses the expression of HSV proteins in cells infected with the CC virus in a HCFC1-dependent manner. Also suppresses the HCFC1-dependent CC transcriptional activation by CREB3 and reduces the amount of CREB3 in CC the cell. Able to down-regulate expression of some cellular genes in CC CREBZF-expressing cells. {ECO:0000269|PubMed:10871379, CC ECO:0000269|PubMed:15705566}. CC -!- SUBUNIT: Interacts with HCFC1; the interaction inhibits CREB3 CC transcriptional activity (PubMed:10871379, PubMed:15705566). Interacts CC with CREB3; the interaction occurs only in combination with HCFC1 CC (PubMed:15705566). {ECO:0000269|PubMed:10871379, CC ECO:0000269|PubMed:15705566}. CC -!- INTERACTION: CC Q9NS37; P14621: ACYP2; NbExp=3; IntAct=EBI-632965, EBI-10198377; CC Q9NS37; P18848: ATF4; NbExp=7; IntAct=EBI-632965, EBI-492498; CC Q9NS37; O43889: CREB3; NbExp=3; IntAct=EBI-632965, EBI-625002; CC Q9NS37; Q9NS37: CREBZF; NbExp=5; IntAct=EBI-632965, EBI-632965; CC Q9NS37; Q8WYA6: CTNNBL1; NbExp=3; IntAct=EBI-632965, EBI-748128; CC Q9NS37; P51610: HCFC1; NbExp=8; IntAct=EBI-632965, EBI-396176; CC Q9NS37; P51610-4: HCFC1; NbExp=3; IntAct=EBI-632965, EBI-18150048; CC Q9NS37; Q14494: NFE2L1; NbExp=3; IntAct=EBI-632965, EBI-2804436; CC Q9NS37; Q16236: NFE2L2; NbExp=5; IntAct=EBI-632965, EBI-2007911; CC Q9NS37; Q15311: RALBP1; NbExp=5; IntAct=EBI-632965, EBI-749285; CC Q9NS37; Q96EB6: SIRT1; NbExp=3; IntAct=EBI-632965, EBI-1802965; CC Q9NS37; O00268: TAF4; NbExp=2; IntAct=EBI-632965, EBI-1034261; CC Q9NS37; Q5W5X9: TTC23; NbExp=3; IntAct=EBI-632965, EBI-6447954; CC Q9NS37; Q5W5X9-3: TTC23; NbExp=3; IntAct=EBI-632965, EBI-9090990; CC Q9NS37; P17861: XBP1; NbExp=4; IntAct=EBI-632965, EBI-6942961; CC Q9NS37; P62509: Esrrg; Xeno; NbExp=3; IntAct=EBI-632965, EBI-5274019; CC Q9NS37; P0C746: HBZ; Xeno; NbExp=3; IntAct=EBI-632965, EBI-10890294; CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15705566}. CC Note=Colocalizes in promyelocytic leukemia protein nuclear bodies (PML- CC NB) with CREB3 and HCFC1. CC -!- TISSUE SPECIFICITY: In adults, expressed most abundantly in heart, CC liver and skeletal muscle, moderately abundant in kidney and pancreas, CC and barely detectable in lung. In fetal tissues, expressed most CC abundantly in kidney and very low amounts in heart, lung and liver. CC {ECO:0000269|PubMed:10871379}. CC -!- MISCELLANEOUS: Named 'Zhangfei' after a legendary Chinese warrior who CC was contemporary with Luman in around 220 AD. CC -!- SIMILARITY: Belongs to the bZIP family. ATF subfamily. {ECO:0000255}. CC -!- SEQUENCE CAUTION: CC Sequence=AAD28325.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; CC Sequence=AAD28325.1; Type=Frameshift; Evidence={ECO:0000305}; CC Sequence=AAZ42189.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; CC Sequence=BAG36256.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; CC Sequence=BAG36256.1; Type=Frameshift; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF039942; AAD28325.1; ALT_SEQ; mRNA. DR EMBL; AP000642; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC060807; AAH60807.1; -; mRNA. DR EMBL; BC093796; AAH93796.2; -; mRNA. DR EMBL; BC093798; AAH93798.2; -; mRNA. DR EMBL; AK313471; BAG36256.1; ALT_SEQ; mRNA. DR EMBL; DQ128105; AAZ42189.1; ALT_INIT; mRNA. DR CCDS; CCDS41697.1; -. DR RefSeq; NP_001034707.1; NM_001039618.2. DR RefSeq; XP_011543497.1; XM_011545195.2. DR RefSeq; XP_016873577.1; XM_017018088.1. DR RefSeq; XP_016873578.1; XM_017018089.1. DR RefSeq; XP_016873579.1; XM_017018090.1. DR RefSeq; XP_016873580.1; XM_017018091.1. DR RefSeq; XP_016873581.1; XM_017018092.1. DR AlphaFoldDB; Q9NS37; -. DR SMR; Q9NS37; -. DR BioGRID; 121817; 31. DR ComplexPortal; CPX-6542; bZIP transcription factor complex, ATF4-CREBZF. DR ComplexPortal; CPX-6601; bZIP transcription factor complex, ATF6B-CREBZF. DR DIP; DIP-33934N; -. DR ELM; Q9NS37; -. DR IntAct; Q9NS37; 29. DR MINT; Q9NS37; -. DR STRING; 9606.ENSP00000433459; -. DR iPTMnet; Q9NS37; -. DR PhosphoSitePlus; Q9NS37; -. DR BioMuta; CREBZF; -. DR DMDM; 251757415; -. DR jPOST; Q9NS37; -. DR MassIVE; Q9NS37; -. DR PaxDb; 9606-ENSP00000433459; -. DR PeptideAtlas; Q9NS37; -. DR ProteomicsDB; 82476; -. DR Antibodypedia; 31388; 245 antibodies from 27 providers. DR DNASU; 58487; -. DR Ensembl; ENST00000490820.2; ENSP00000434281.1; ENSG00000137504.16. DR Ensembl; ENST00000527447.2; ENSP00000433459.1; ENSG00000137504.16. DR GeneID; 58487; -. DR KEGG; hsa:58487; -. DR MANE-Select; ENST00000527447.2; ENSP00000433459.1; NM_001039618.4; NP_001034707.1. DR UCSC; uc001pas.3; human. DR AGR; HGNC:24905; -. DR CTD; 58487; -. DR DisGeNET; 58487; -. DR GeneCards; CREBZF; -. DR HGNC; HGNC:24905; CREBZF. DR HPA; ENSG00000137504; Low tissue specificity. DR MIM; 606444; gene. DR neXtProt; NX_Q9NS37; -. DR OpenTargets; ENSG00000137504; -. DR PharmGKB; PA162382821; -. DR VEuPathDB; HostDB:ENSG00000137504; -. DR eggNOG; ENOG502S3I0; Eukaryota. DR GeneTree; ENSGT00390000016589; -. DR InParanoid; Q9NS37; -. DR OMA; ARPDWDL; -. DR OrthoDB; 6606299at2759; -. DR PhylomeDB; Q9NS37; -. DR TreeFam; TF336153; -. DR PathwayCommons; Q9NS37; -. DR SignaLink; Q9NS37; -. DR BioGRID-ORCS; 58487; 19 hits in 1161 CRISPR screens. DR ChiTaRS; CREBZF; human. DR GenomeRNAi; 58487; -. DR Pharos; Q9NS37; Tbio. DR PRO; PR:Q9NS37; -. DR Proteomes; UP000005640; Chromosome 11. DR RNAct; Q9NS37; protein. DR Bgee; ENSG00000137504; Expressed in sural nerve and 198 other cell types or tissues. DR ExpressionAtlas; Q9NS37; baseline and differential. DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB. DR GO; GO:0005739; C:mitochondrion; IDA:HPA. DR GO; GO:0005654; C:nucleoplasm; IDA:HPA. DR GO; GO:0005634; C:nucleus; IDA:UniProtKB. DR GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IPI:ComplexPortal. DR GO; GO:0003677; F:DNA binding; NAS:UniProtKB. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB. DR GO; GO:0042802; F:identical protein binding; IPI:IntAct. DR GO; GO:0036500; P:ATF6-mediated unfolded protein response; NAS:ComplexPortal. DR GO; GO:0140467; P:integrated stress response signaling; NAS:ComplexPortal. DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IMP:UniProtKB. DR GO; GO:0045814; P:negative regulation of gene expression, epigenetic; IEP:UniProtKB. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:ComplexPortal. DR GO; GO:0051090; P:regulation of DNA-binding transcription factor activity; IDA:UniProtKB. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IDA:GO_Central. DR GO; GO:0009615; P:response to virus; IDA:UniProtKB. DR FunFam; 1.20.5.170:FF:000070; CREB/ATF bZIP transcription factor; 1. DR Gene3D; 1.20.5.170; -; 1. DR InterPro; IPR004827; bZIP. DR InterPro; IPR046347; bZIP_sf. DR Pfam; PF00170; bZIP_1; 1. DR SUPFAM; SSF57959; Leucine zipper domain; 1. PE 1: Evidence at protein level; KW Nucleus; Phosphoprotein; Proteomics identification; Reference proteome; KW Transcription; Transcription regulation. FT CHAIN 1..354 FT /note="CREB/ATF bZIP transcription factor" FT /id="PRO_0000076645" FT DOMAIN 204..267 FT /note="bZIP" FT REGION 1..95 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 113..156 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 171..214 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 219..226 FT /note="Basic motif" FT /evidence="ECO:0000250" FT REGION 232..267 FT /note="Leucine-zipper" FT /evidence="ECO:0000250" FT MOTIF 303..306 FT /note="HCFC1-binding motif (HBM)" FT /evidence="ECO:0000269|PubMed:10871379" FT MOD_RES 50 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:24275569" FT MUTAGEN 303 FT /note="D->A: Significantly reduced binding to HCFC1." FT /evidence="ECO:0000269|PubMed:10871379" FT MUTAGEN 304 FT /note="H->A: Significantly reduced binding to HCFC1." FT /evidence="ECO:0000269|PubMed:10871379" FT MUTAGEN 306 FT /note="Y->A: Does not interact with HCFC1 and is FT inefficient at inhibiting CREB3 transcriptional activity. FT Does not colocalize with CREB3 in promyelocytic leukemia FT protein nuclear bodies (PML-NB)." FT /evidence="ECO:0000269|PubMed:10871379, FT ECO:0000269|PubMed:15705566" FT CONFLICT 16 FT /note="S -> F (in Ref. 3; AAH60807)" FT /evidence="ECO:0000305" SQ SEQUENCE 354 AA; 37134 MW; BE3AC77203216155 CRC64; MRHSLTKLLA ASGSNSPTRS ESPEPAATCS LPSDLTRAAA GEEETAAAGS PGRKQQFGDE GELEAGRGSR GGVAVRAPSP EEMEEEAIAS LPGEETEDMD FLSGLELADL LDPRQPDWHL DPGLSSPGPL SSSGGGSDSG GLWRGDDDDE AAAAEMQRFS DLLQRLLNGI GGCSSSSDSG SAEKRRRKSP GGGGGGGSGN DNNQAATKSP RKAAAAAARL NRLKKKEYVM GLESRVRGLA AENQELRAEN RELGKRVQAL QEESRYLRAV LANETGLARL LSRLSGVGLR LTTSLFRDSP AGDHDYALPV GKQKQDLLEE DDSAGGVCLH VDKDKVSVEF CSACARKASS SLKM //