ID FGF20_HUMAN Reviewed; 211 AA. AC Q9NP95; DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2000, sequence version 1. DT 19-OCT-2011, entry version 83. DE RecName: Full=Fibroblast growth factor 20; DE Short=FGF-20; GN Name=FGF20; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=20374469; PubMed=10913340; DOI=10.1006/bbrc.2000.3142; RA Kirikoshi H., Sagara N., Saitoh T., Tanaka K., Sekihara H., RA Shiokawa K., Katoh M.; RT "Molecular cloning and characterization of human FGF-20 on chromosome RT 8p21.3-p22."; RL Biochem. Biophys. Res. Commun. 274:337-343(2000). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Brain; RX MEDLINE=20490008; PubMed=11032730; DOI=10.1006/bbrc.2000.3675; RA Ohmachi S., Watanabe Y., Mikami T., Kusu N., Ibi T., Akaike A., RA Itoh N.; RT "FGF-20, a novel neurotrophic factor, preferentially expressed in the RT substantia nigra pars compacta of rat brain."; RL Biochem. Biophys. Res. Commun. 277:355-360(2000). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE RP SPECIFICITY. RX PubMed=11306498; RA Jeffers M., Shimkets R., Prayaga S., Boldog F., Yang M., Burgess C., RA Fernandes E., Rittman B., Shimkets J., LaRochelle W.J., RA Lichenstein H.S.; RT "Identification of a novel human fibroblast growth factor and RT characterization of its role in oncogenesis."; RL Cancer Res. 61:3131-3138(2001). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ARG-116; ALA-175 AND RP ASN-206. RG NIEHS SNPs program; RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases. RN [5] RP INTERACTION WITH FGFR2 AND FGFR4, AND FUNCTION IN STIMULATION OF CELL RP PROLIFERATION. RX PubMed=16597617; DOI=10.1074/jbc.M601252200; RA Zhang X., Ibrahimi O.A., Olsen S.K., Umemori H., Mohammadi M., RA Ornitz D.M.; RT "Receptor specificity of the fibroblast growth factor family. The RT complete mammalian FGF family."; RL J. Biol. Chem. 281:15694-15700(2006). RN [6] RP REVIEW. RX PubMed=20094046; DOI=10.1038/nrc2780; RA Turner N., Grose R.; RT "Fibroblast growth factor signalling: from development to cancer."; RL Nat. Rev. Cancer 10:116-129(2010). RN [7] RP X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS), SUBUNIT, AND HEPARIN BINDING. RX PubMed=19564416; DOI=10.1128/MCB.01780-08; RA Kalinina J., Byron S.A., Makarenkova H.P., Olsen S.K., RA Eliseenkova A.V., Larochelle W.J., Dhanabal M., Blais S., Ornitz D.M., RA Day L.A., Neubert T.A., Pollock P.M., Mohammadi M.; RT "Homodimerization controls the fibroblast growth factor 9 subfamily's RT receptor binding and heparan sulfate-dependent diffusion in the RT extracellular matrix."; RL Mol. Cell. Biol. 29:4663-4678(2009). CC -!- FUNCTION: Neurotrophic factor that regulates central nervous CC development and function. CC -!- SUBUNIT: Homodimer. Interacts with FGFR2 and FGFR4. Affinity CC between fibroblast growth factors (FGFs) and their receptors is CC increased by heparan sulfate glycosaminoglycans that function as CC coreceptors. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Predominantly expressed in the cerebellum. CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family. CC -!- WEB RESOURCE: Name=NIEHS-SNPs; CC URL="http://egp.gs.washington.edu/data/fgf20/"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB044277; BAB03633.1; -; mRNA. DR EMBL; AB030648; BAB03530.1; -; mRNA. DR EMBL; AY696296; AAT85804.1; -; Genomic_DNA. DR IPI; IPI00014608; -. DR PIR; JC7353; JC7353. DR RefSeq; NP_062825.1; NM_019851.2. DR UniGene; Hs.199905; -. DR PDB; 3F1R; X-ray; 2.50 A; A/B=1-211. DR PDBsum; 3F1R; -. DR ProteinModelPortal; Q9NP95; -. DR SMR; Q9NP95; 52-208. DR STRING; Q9NP95; -. DR PhosphoSite; Q9NP95; -. DR PRIDE; Q9NP95; -. DR Ensembl; ENST00000180166; ENSP00000180166; ENSG00000078579. DR GeneID; 26281; -. DR KEGG; hsa:26281; -. DR UCSC; uc003wxc.1; human. DR CTD; 26281; -. DR GeneCards; GC08M015395; -. DR H-InvDB; HIX0034235; -. DR HGNC; HGNC:3677; FGF20. DR MIM; 605558; gene. DR neXtProt; NX_Q9NP95; -. DR GeneTree; ENSGT00600000084030; -. DR HOGENOM; HBG715603; -. DR HOVERGEN; HBG007580; -. DR InParanoid; Q9NP95; -. DR OMA; YKDILMY; -. DR OrthoDB; EOG46WZ9V; -. DR PhylomeDB; Q9NP95; -. DR Reactome; REACT_498; Signaling by Insulin receptor. DR Reactome; REACT_9470; Signaling by FGFR. DR NextBio; 48605; -. DR ArrayExpress; Q9NP95; -. DR Bgee; Q9NP95; -. DR CleanEx; HS_FGF20; -. DR Genevestigator; Q9NP95; -. DR GermOnline; ENSG00000078579; Homo sapiens. DR GO; GO:0005576; C:extracellular region; TAS:Reactome. DR GO; GO:0005625; C:soluble fraction; TAS:ProtInc. DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW. DR GO; GO:0004713; F:protein tyrosine kinase activity; TAS:Reactome. DR GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc. DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome. DR GO; GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome. DR InterPro; IPR008996; Cytokine_IL1-like. DR InterPro; IPR002209; GF_heparin-bd. DR InterPro; IPR002348; IL1_HBGF. DR PANTHER; PTHR11486; IL1_HBGF; 1. DR Pfam; PF00167; FGF; 1. DR PRINTS; PR00263; HBGFFGF. DR PRINTS; PR00262; IL1HBGF. DR SMART; SM00442; FGF; 1. DR SUPFAM; SSF50353; Cytok_IL1_like; 1. DR PROSITE; PS00247; HBGF_FGF; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Growth factor; Polymorphism; KW Reference proteome; Secreted. FT CHAIN 1 211 Fibroblast growth factor 20. FT /FTId=PRO_0000147616. FT VARIANT 116 116 G -> R (in dbSNP:rs3793405). FT /FTId=VAR_020946. FT VARIANT 175 175 P -> A (in dbSNP:rs10089600). FT /FTId=VAR_020947. FT VARIANT 206 206 D -> N (in dbSNP:rs17550360). FT /FTId=VAR_020948. FT HELIX 56 60 FT STRAND 66 71 FT STRAND 98 101 FT STRAND 108 111 FT HELIX 135 137 FT STRAND 139 145 FT STRAND 148 157 FT STRAND 164 166 FT HELIX 186 188 FT STRAND 190 193 FT HELIX 197 199 FT HELIX 201 203 SQ SEQUENCE 211 AA; 23499 MW; AB04608C16060CC1 CRC64; MAPLAEVGGF LGGLEGLGQQ VGSHFLLPPA GERPPLLGER RSAAERSARG GPGAAQLAHL HGILRRRQLY CRTGFHLQIL PDGSVQGTRQ DHSLFGILEF ISVAVGLVSI RGVDSGLYLG MNDKGELYGS EKLTSECIFR EQFEENWYNT YSSNIYKHGD TGRRYFVALN KDGTPRDGAR SKRHQKFTHF LPRPVDPERV PELYKDLLMY T //